Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties

Autor: Man Chin Chung, Jean Leandro dos Santos, Ednir Vizioli Oliveira, Lorena Blau, Renato Farina Menegon, Rosângela Gonçalves Peccinini

Publikováno v: Molecules, Vol 14, Iss 9, Pp 3187-3197 (2009)

The compound 1-(2,6-dichlorophenyl)indolin-2-one (1), planned as a pro-drug of diclofenac (2), was easily synthesized in 94% yield by an intramolecular reaction in the presence of coupling agent (i.e., EDC). Compound 1 showed anti-inflammatory and an

Externí odkaz: https://doaj.org/article/8f4188048bea48b2b5bc5cf916c10b99

Prodrugs for the Treatment of Neglected Diseases

Autor: Man Chin Chung, Elizabeth Igne Ferreira, Jean Leandro Santos, Jeanine Giarolla, Daniela Gonçales Rando, Adélia Emília Almeida, Priscila Longhin Bosquesi, Renato Farina Menegon, Lorena Blau

Publikováno v: Molecules, Vol 13, Iss 3, Pp 616-677 (2008)

Recently, World Health Organization (WHO) and Medicins San Frontieres (MSF) proposed a classification of diseases as global, neglected and extremely neglected. Global diseases, such as cancer, cardiovascular and mental (CNS) diseases represent the ta

Externí odkaz: https://doaj.org/article/636b91f683504073bca22e1c5ff53396

Wound healing properties and mucilage content of Pereskia aculeata from different substrates

Autor: Lorena Blau, Cristina Pacheco Soares, Eber Goulart Carvalho, Walderez Moreira Joaquim, Renato Farina Menegon

Publikováno v: Revista Brasileira de Farmacognosia, Vol 24, Iss 6, Pp 677-682
Revista Brasileira de Farmacognosia, Vol 24, Iss 6, Pp 677-682 (2014)
Revista Brasileira de Farmacognosia, Volume: 24, Issue: 6, Pages: 677-682, Published: DEC 2014
Revista Brasileira de Farmacognosia v.24 n.6 2014
Revista Brasileira de Farmacognosia
Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA

Pereskia aculeata Mill., Cactaceae, is a cactus with high mucilage production, well-known for its nutritional properties. Folk use consists on skin injuries, and mucilage is probably involved in the wound healing activity. This work studied some aspe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41eeafd515391eeede7a55b7d0986a1
https://doi.org/10.1016/j.bjp.2014.11.008

A Nonstaining and Tasteless Hydrophobic Salt of Chlorhexidine

Autor: Antonio Carlos Pizzolitto, Magali Monteiro, Marcos Antônio Corrêa, Man Chin Chung, Lorena Blau, Renato Farina Menegon, Natália Soares Janzantti

Publikováno v: Journal of Pharmaceutical Sciences. 100:3130-3138

Chlorhexidine (CHX) remains one of the most effective and widely used antiplaque agents around the world, although its side effects still limit a long-term usage as the patient compliance for oral treatment with CHX. We hypothesize that a less water-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd8210e418e1462301b7ae3c9fd9d26
https://doi.org/10.1002/jps.22517

Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia

Autor: Man Chin Chung, Lorena Blau, Renato Farina Menegon

Publikováno v: Química Nova v.29 n.6 2006
Química Nova
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Química Nova, Volume: 29, Issue: 6, Pages: 1307-1317, Published: DEC 2006
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Química Nova, Vol 29, Iss 6, Pp 1307-1317 (2006)

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:22:01Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:28:32Z : No. of bitstreams: 1 2-s2.0-33845716527.pdf: 777036 bytes, checksum: 46c2160df67d3db0d2a46

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009cdd55df8954fb8dbaeeac8cc3447f
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600028