Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Lorena Benedetti"'
Autor:
Daniel Feliciano, Carolyn M. Ott, Isabel Espinosa-Medina, Aubrey V. Weigel, Lorena Benedetti, Kristin M. Milano, Zhonghua Tang, Tzumin Lee, Harvey J. Kliman, Seth M. Guller, Jennifer Lippincott-Schwartz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Cells in many tissues fuse into syncytia acquiring new functions. By investigating whether physical remodelling promotes differentiation, here, the authors show that plasma membrane diminution post-fusion causes transient nutrient stress that inhibit
Externí odkaz:
https://doaj.org/article/d6d425d62b8e4205a0ee1957f8d2d03b
Autor:
Thanos P. Mourikis, Lorena Benedetti, Elizabeth Foxall, Damjan Temelkovski, Joel Nulsen, Juliane Perner, Matteo Cereda, Jesper Lagergren, Michael Howell, Christopher Yau, Rebecca C. Fitzgerald, Paola Scaffidi, The Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Francesca D. Ciccarelli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Identifying driver genes in unstable, heterogenous tumour types can be challenging. Here, Mourikis, Benedetti, Foxall and colleagues present a machine learning algorithm to tackle this problem in esophageal adenocarcinoma.
Externí odkaz:
https://doaj.org/article/6525c04e989d4f92801eb2e25637bf6b
Autor:
Gael Genet, Kevin Boyé, Thomas Mathivet, Roxana Ola, Feng Zhang, Alexandre Dubrac, Jinyu Li, Nafiisha Genet, Luiz Henrique Geraldo, Lorena Benedetti, Steffen Künzel, Laurence Pibouin-Fragner, Jean-Leon Thomas, Anne Eichmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
VEGF-A/VEGFR2 signaling is a key driver of endothelial cell migration during sprouting angiogenesis. Here Genet et al. show that endophilin A2 regulates these processes by mediating clathrin-independent VEGFR2 internalization.
Externí odkaz:
https://doaj.org/article/a65242a5aee94d9999a57269b93f9bd4
Autor:
Lorena Benedetti, Jonathan S Marvin, Hanieh Falahati, Andres Guillén-Samander, Loren L Looger, Pietro De Camilli
Publikováno v:
eLife, Vol 9 (2020)
Light-inducible dimerization protein modules enable precise temporal and spatial control of biological processes in non-invasive fashion. Among them, Magnets are small modules engineered from the Neurospora crassa photoreceptor Vivid by orthogonalizi
Externí odkaz:
https://doaj.org/article/b309da32d02f469c8c76ebb8197e3475
Autor:
Lazaros Lataniotis, Andreas Albrecht, Fatma O. Kok, Clinton A. L. Monfries, Lorena Benedetti, Nathan D. Lawson, Simon M. Hughes, Kathleen Steinhofel, Manuel Mayr, Anna Zampetaki
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract MicroRNAs (miRNAs) are important regulators of diverse physiological and pathophysiological processes. MiRNA families and clusters are two key features in miRNA biology. Here we explore the use of CRISPR/Cas9 as a powerful tool to delineate
Externí odkaz:
https://doaj.org/article/c6f1f4ed873b4bfc9c27edba831e3e8f
Autor:
Jonathan Zapata, Edoardo Moretto, Saad Hannan, Luca Murru, Anna Longatti, Davide Mazza, Lorena Benedetti, Matteo Fossati, Christopher Heise, Luisa Ponzoni, Pamela Valnegri, Daniela Braida, Mariaelvina Sala, Maura Francolini, Jeffrey Hildebrand, Vera Kalscheuer, Francesca Fanelli, Carlo Sala, Bernhard Bettler, Silvia Bassani, Trevor G. Smart, Maria Passafaro
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Mutations in the gene encoding Shrm4 are associated with epilepsy and intellectual disability. The authors show that Shrm4 interacts with GABABreceptors and regulates tonic inhibition in the hippocampus, and knockdown of Shrm4 in rats leads to anxiet
Externí odkaz:
https://doaj.org/article/4624279b47d64159ad6a26ab96fc80e0
Autor:
Matteo Cereda, Gennaro Gambardella, Lorena Benedetti, Fabio Iannelli, Dominic Patel, Gianluca Basso, Rosalinda F. Guerra, Thanos P. Mourikis, Ignazio Puccio, Shruti Sinha, Luigi Laghi, Jo Spencer, Manuel Rodriguez-Justo, Francesca D. Ciccarelli
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Some individuals present with multiple synchronous colorectal tumours, but the genetic understanding of this is unclear. Here, the authors use a sequencing strategy to show that the synchronous tumours are genetically independent and the patients har
Externí odkaz:
https://doaj.org/article/53dd8c3165584a758cf01d490afce229
Autor:
Claudia Bazzini, Lorena Benedetti, Davide Civello, Chiara Zanoni, Valeria Rossetti, Davide Marchesi, Maria Lisa Garavaglia, Markus Paulmichl, Maura Francolini, Giuliano Meyer, Simona Rodighiero
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108826 (2014)
To optimise the efficiency of cell machinery, cells can use the same protein (often called a hub protein) to participate in different cell functions by simply changing its target molecules. There are large data sets describing protein-protein interac
Externí odkaz:
https://doaj.org/article/c10fc36264be49f6b6f09d261c313d6b
Autor:
Harvey J. Kliman, Lorena Benedetti, Zhonghua Tang, Tzumin Lee, Isabel Espinosa-Medina, Jennifer Lippincott-Schwartz, Kristin M. Milano, Seth Guller, Aubrey V. Weigel, Carolyn Ott, Daniel Feliciano
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Cells in many tissues, such as bone, muscle, and placenta, fuse into syncytia to acquire new functions and transcriptional programs. While it is known that fused cells are specialized, it is unclear whether cell-fusion itself contributes to programma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a11f28466866396a690194b1272bc5e
https://doaj.org/article/d6d425d62b8e4205a0ee1957f8d2d03b
https://doaj.org/article/d6d425d62b8e4205a0ee1957f8d2d03b
Autor:
Richard B. Crouse, Lorena Benedetti
Publikováno v:
J STEM Outreach
The Flipped Science Fair (FSF) transforms the traditional science fair format by having middle-school students judge the research of early career scientists. At the FSF, students learn about cutting-edge research in a small group setting, with opport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03e200e3e86873e1d7056b263293084
https://pubmed.ncbi.nlm.nih.gov/33718806
https://pubmed.ncbi.nlm.nih.gov/33718806