Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Lorena Agudo-Ibáñez"'
Autor:
Tapesh Santra, Ana Herrero, Javier Rodriguez, Alex von Kriegsheim, Luis F. Iglesias-Martinez, Thomas Schwarzl, Des Higgins, Thin-Thin Aye, Albert J.R. Heck, Fernando Calvo, Lorena Agudo-Ibáñez, Piero Crespo, David Matallanas, Walter Kolch
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 3100-3115.e7 (2019)
Summary: Modern omics technologies allow us to obtain global information on different types of biological networks. However, integrating these different types of analyses into a coherent framework for a comprehensive biological interpretation remains
Externí odkaz:
https://doaj.org/article/27f030445e9a4cbe8d263125c8df11ff
Autor:
Lorena Agudo-Ibáñez, Fernando Calvo, Mariana Reis-Cardoso, Walter Kolch, Carolanne Doherty, David Matallanas, Iñaki Jiménez-Gómez, Ana Herrero, Adán Pinto, Piero Crespo
Publikováno v:
Small GTPases
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Ras GTPases convey signals from different types of membranes. At these locations, different Ras isoforms, interactors and regulators generate different biochemical signals and biological outputs. The study of Ras localisation-specific signal transduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70abd49219bab266e5670e6bb29ed08
http://hdl.handle.net/10261/234208
http://hdl.handle.net/10261/234208
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
[In correction]: “H-Ras Distribution and Signaling in Plasma Membrane Microdomains Are Regulated by Acylation and Deacylation Events”. doi: https://doi.org/10.1128/MCB.01398-14.
Volume 35, no. 11, p. 1898 –1914, 2015, https://doi.org/10.11
Volume 35, no. 11, p. 1898 –1914, 2015, https://doi.org/10.11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d513ca0f30c1b4e7cda7c8db7556e1
http://hdl.handle.net/10261/248990
http://hdl.handle.net/10261/248990
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Methods in Molecular Biology ISBN: 9781493964222
instname
Methods in Molecular Biology ISBN: 9781493964222
A vast number of stimuli use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their cognate receptors, in order to regulate multiple cellular functions, including key processes such as proliferation, cell cycle progression, differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6dd4a93b788b600166093d38108f6d
http://hdl.handle.net/10261/164595
http://hdl.handle.net/10261/164595
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular Biology of the Cell
instname
Molecular Biology of the Cell
Signals conveyed through the RAS-ERK pathway are essential for the determination of cell fate. It is well established that signal variability is achieved in the different microenvironments in which signals unfold. It is also known that signal duratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e505ad1e1603596d9bed2d87c3f045e5
http://hdl.handle.net/10261/164482
http://hdl.handle.net/10261/164482
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
H-Ras must adhere to the plasma membrane to be functional. This is accomplished by posttranslational modifications, including palmitoylation, a reversible process whereby H-Ras traffics between the plasma membrane and the Golgi complex. At the plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d6703b9767c6b00e10627faf8decda
http://hdl.handle.net/10261/130576
http://hdl.handle.net/10261/130576
Autor:
Fernando Calvo, Erik Sahai, Lorena Agudo-Ibáñez, Christopher J. Marshall, Victoria Sanz-Moreno, Fredrik Wallberg, Piero Crespo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Individual tumour cells move in three-dimensional environments with either a rounded or an elongated ‘mesenchymal’ morphology. These two modes of movement are tightly regulated by Rho family GTPases: elongated movement requires activation of Rac1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ced59f0b83ea9b3faf024c9eb1f035
http://hdl.handle.net/10261/49384
http://hdl.handle.net/10261/49384
The Ras-ERK pathway: understanding site-specific signaling provides hope of new anti-tumor therapies
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Recent discoveries have suggested the concept that intracellular signals are the sum of multiple, site-specified subsignals, rather than single, homogeneous entities. In the context of cancer, searching for compounds that selectively block subsignals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4bfb42792f0358fe649ce3259fae2b
https://pubmed.ncbi.nlm.nih.gov/20414899
https://pubmed.ncbi.nlm.nih.gov/20414899
Autor:
Berta Casar, Imanol Arozarena, Richard Marais, Lorena Agudo-Ibáñez, Victoria Sanz-Moreno, Robert E. Lewis, Maria T. Berciano, Piero Crespo, Adán Pinto
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Subcellular localization influences the nature of Ras/extracellular signal-regulated kinase (ERK) signals by unknown mechanisms. Herein, we demonstrate that the microenvironment from which Ras signals emanate determines which substrates will be prefe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51388a94a89fbb5979b623a6d3450374
http://hdl.handle.net/10261/50094
http://hdl.handle.net/10261/50094
Autor:
Fernando Calvo, Lorena Agudo-Ibáñez, Inma M. Berenjeno, Piero Crespo, Fátima Núñez, Xosé R. Bustelo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
El pdf del artículo es el manuscrito de autor.
Ras proteins are distributed in distinct plasma-membrane microdomains and endomembranes. The biochemical signals generated by Ras therein differ qualitatively and quantitatively, but the extent to
Ras proteins are distributed in distinct plasma-membrane microdomains and endomembranes. The biochemical signals generated by Ras therein differ qualitatively and quantitatively, but the extent to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1deafb9e32d084cb0b40dd9d29522487
http://hdl.handle.net/10261/5124
http://hdl.handle.net/10261/5124