Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lorena A, Kallal"'
Autor:
Christopher L. Carpenter, Eldridge N. Nartey, Dominic Suarez, Elisabeth A. Minthorn, Jesus R. Medina, Louis V. LaFrance, Ralph A. Rivero, James F. Mack, Charles F. McHugh, Xinrong Tian, Dirk A. Heerding, Christina Ng Di Marco, Thomas J. Berrodin, Aishwarya Bhaskar, Biju Mangatt, William Hoi Hong Li, Brackley James, Martyr Cuthbert, Lorena A. Kallal, Michael Butticello, Jacob Rubin
Publikováno v:
Journal of Medicinal Chemistry. 64:16056-16087
Elevated expression of the c-MYC oncogene is one of the most common abnormalities in human cancers. Unfortunately, efforts to identify pharmacological inhibitors that directly target MYC have not yet yielded a drug-like molecule due to the lack of an
Autor:
Jesús R, Medina, Xinrong, Tian, William H, Li, Dominic, Suarez, James F, Mack, Louis, LaFrance, Cuthbert, Martyr, James, Brackley, Christina, Di Marco, Ralph, Rivero, Dirk A, Heerding, Charles, McHugh, Elisabeth, Minthorn, Aishwarya, Bhaskar, Jacob, Rubin, Michael, Butticello, Christopher, Carpenter, Eldridge N, Nartey, Thomas J, Berrodin, Lorena A, Kallal, Biju, Mangatt
Publikováno v:
Journal of medicinal chemistry. 64(21)
Elevated expression of the
Autor:
Widdowson Katherine L, Lorena A. Kallal, Yvett Sosa, Matthew S. Steiginga, Michael T. Ouellette, Myles H. Akabas, I. J. Frame, Andrew J. Pope, Roman Deniskin, Todd L. Graybill, Deepak Bandyopadhyay, Robert J. Young
Publikováno v:
ACS Infectious Diseases. 5:1738-1753
Emerging resistance to current antimalarial medicines underscores the importance of identifying new drug targets and novel compounds. Malaria parasites are purine auxotrophic and import purines via the Plasmodium falciparum equilibrative nucleoside t
Autor:
David J Rickard, Clark A Sehon, Viera Kasparcova, Lorena A Kallal, Pamela A Haile, Xin Zeng, Monica N Montoute, Derek D Poore, Hu Li, Zining Wu, Patrick M Eidam, John G Emery, Robert W Marquis, Peter J Gough, John Bertin
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96737 (2014)
NOD1 is an intracellular pattern recognition receptor that recognizes diaminopimelic acid (DAP), a peptidoglycan component in gram negative bacteria. Upon ligand binding, NOD1 assembles with receptor-interacting protein (RIP)-2 kinase and initiates a
Externí odkaz:
https://doaj.org/article/d8966b29a270430a972aa590bfa33f4f
High-Throughput Screening and Triage Assays Identify Small Molecules Targeting c-MYC in Cancer Cells
Autor:
Jon-Paul Jaworski, Lisa A. Payne, Anna Waszkiewicz, Biju Mangatt, Anthony J. Jurewicz, Lorena A. Kallal, Jesus R. Medina, Pat Brady, Xin Zeng, Thomas J. Berrodin, Carolyn Doepner-Buser, Anthony Della Pietra
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(2)
While c-MYC is well established as a proto-oncogene, its structure and function as a transcription factor have made c-MYC a difficult therapeutic target. To identify small-molecule inhibitors targeting c-MYC for anticancer therapy, we designed a high
Autor:
David J Rickard, Clark A Sehon, Viera Kasparcova, Lorena A Kallal, Xin Zeng, Monica N Montoute, Tushar Chordia, Derek D Poore, Hu Li, Zining Wu, Patrick M Eidam, Pamela A Haile, Jong Yu, John G Emery, Robert W Marquis, Peter J Gough, John Bertin
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e69619 (2013)
NOD2 is an intracellular pattern recognition receptor that assembles with receptor-interacting protein (RIP)-2 kinase in response to the presence of bacterial muramyl dipeptide (MDP) in the host cell cytoplasm, thereby inducing signals leading to the
Externí odkaz:
https://doaj.org/article/5e593a2a329d48da9774642aa0357266
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(2)
Thermal shift assays (TSAs) can reveal changes in protein structure, due to a resultant change in protein thermal stability. Since proteins are often stabilized upon binding of ligand molecules, these assays can provide a readout for protein target e
Autor:
Yvett, Sosa, Roman, Deniskin, I J, Frame, Matthew S, Steiginga, Deepak, Bandyopadhyay, Todd L, Graybill, Lorena A, Kallal, Michael T, Ouellette, Andrew J, Pope, Katherine L, Widdowson, Robert J, Young, Myles H, Akabas
Publikováno v:
ACS Infect Dis
Emerging resistance to current antimalarial medicines underscores the importance of identifying new drug targets and novel compounds. Malaria parasites are purine auxotrophic and import purines via the Plasmodium falciparum Equilibrative Nucleoside T
Autor:
Elizabeth Nixon, Lorena A. Kallal, Michael Weglos, Snehal Bhatt, Maggie Truong, Jeffrey W. Gross, Sue Crimmin
Publikováno v:
SLAS technology. 24(3)
Recent advancements in science and engineering are revolutionizing our understanding of an individual's disease, and with this knowledge we are gaining an increasingly sophisticated understanding of how discovery can be transformed to deliver persona
Autor:
Quinn Lu, Tiger W. Bee, Pankaj K. Agarwal, Dwight M. Morrow, Xin Zeng, Zining Wu, Monica N. Montoute, Hong Lin, Andrew J. Pope, Yan Liu, Da-Yuan Wang, Lorena A. Kallal
Publikováno v:
SLAS Discovery. 21:260-268
Abnormal accumulation of β-catenin protein, a key transcriptional activator required for Wnt signaling, is the hallmark of many tumor types, including colon cancer. In normal cells, β-catenin protein level is tightly controlled by a multiprotein co