Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Loren P. Thompson"'
Autor:
Hong Song, Loren P. Thompson
Publikováno v:
Reproductive Sciences.
Chronic intrauterine hypoxia is a significant pregnancy complication impacting fetal heart growth, metabolism, and mitochondrial function, contributing to cardiovascular programming of the offspring. PGC1α (peroxisome proliferator-activated receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2576d3e71e11ff35606bd0676507f10
https://doi.org/10.1007/s43032-023-01245-5
https://doi.org/10.1007/s43032-023-01245-5
Autor:
Emad A. Elsamadicy, Loren P. Thompson
Publikováno v:
Reproductive Sciences. 29:3015-3025
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e7ebc80e7376022add8079d73f76f06
https://doi.org/10.1007/s43032-022-00979-y
https://doi.org/10.1007/s43032-022-00979-y
Autor:
Emad A, Elsamadicy, Loren P, Thompson
Publikováno v:
Reproductive sciences (Thousand Oaks, Calif.). 29(10)
Chronic hypoxia can cause fetal growth restriction (FGR) through placental dysfunction. Insulin-like growth factors (IGFs), such as IGF-2, play a major role in preservation of placental growth and function. We investigated the effects of chronic hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e33dad8c0e6b75b0076ac80a8a8dc1c3
https://pubmed.ncbi.nlm.nih.gov/35616874
https://pubmed.ncbi.nlm.nih.gov/35616874
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
We hypothesize that intrauterine hypoxia (HPX) alters the mitochondrial phenotype in fetal hearts contributing to developmental programming. Pregnant guinea pigs were exposed to normoxia (NMX) or hypoxia (HPX, 10.5% O2), starting at early [25 days (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5322770f79c04b8a869df6babee59a10
https://pubmed.ncbi.nlm.nih.gov/34730023
https://pubmed.ncbi.nlm.nih.gov/34730023
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Chronic intrauterine hypoxia is a programming stimulus of cardiovascular dysfunction. While the fetal heart adapts to the reduced oxygenation, the offspring heart becomes vulnerable to subsequent metabolic challenges as an adult. Cardiac mitochondria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c6bd880581b5a866e0111496bfdef4
https://doi.org/10.1155/2019/7210249
https://doi.org/10.1155/2019/7210249
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 315:R1232-R1241
Adverse intrauterine conditions cause fetal growth restriction and increase the risk of adult cardiovascular disease. We hypothesize that intrauterine hypoxia impairs fetal heart function, is sustained after birth, and manifests as both cardiac and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1ab0de9f1c3594781148c9d0f56ab3
https://doi.org/10.1152/ajpregu.00224.2018
https://doi.org/10.1152/ajpregu.00224.2018
Publikováno v:
Reproductive sciences (Thousand Oaks, Calif.). 29(1)
Mitochondrial dysfunction is an underlying cause of childhood neurological disease secondary to the crucial role of mitochondria in proper neurodevelopment. We hypothesized that chronic intrauterine hypoxia (HPX) induces mitochondrial deficits by alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49dcdbf2166fbdcc258d27ddefb2ddfa
https://pubmed.ncbi.nlm.nih.gov/34750769
https://pubmed.ncbi.nlm.nih.gov/34750769
Autor:
Loren P. Thompson, Yazan Al-Hasan
Publikováno v:
Journal of Pregnancy, Vol 2012 (2012)
Intrauterine stress induces increased risk of adult disease through fetal programming mechanisms. Oxidative stress can be generated by several conditions, such as, prenatal hypoxia, maternal under- and overnutrition, and excessive glucocorticoid expo
Externí odkaz:
https://doaj.org/article/e78795cfcd6e422986db1573745626c4
Publikováno v:
Biology of Reproduction. 100:208-216
Placental hypoxia can stimulate oxidative stress and mitochondrial dysfunction reducing placental efficiency and inducing fetal growth restriction (FGR). We hypothesized that chronic hypoxia inhibits mitochondrial function in the placenta as an under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd73e314b850e5f25a97a8c2e7123c85
https://doi.org/10.1093/biolre/ioy167
https://doi.org/10.1093/biolre/ioy167
Autor:
Aya Sasaki, Kimberley J. Botting, Stephen G. Matthews, Rebecca M. Dyson, Jonathan J. Hirst, Anna L. David, Loren P. Thompson, Janna L. Morrison, Clint Gray, Timothy R.H. Regnault, Mary J. Berry, Bryan S. Richardson, Karen L. Kind, Emilio A. Herrera, Bona Kim, Jack R. T. Darby, Bernardo J. Krause, Kathryn L. Gatford, Hannah K. Palliser
Publikováno v:
The Journal of Physiology. 596:5535-5569
Over 30 years ago Sir David Barker first proposed the theory that events in early life could explain an individuals' risk of non-communicable disease in later life; the Developmental Origins of Health and Disease (DOHaD) theory. During the 1990s the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::491fb3b921e88f7d7ad9833025d9bf21
https://doi.org/10.1113/jp274948
https://doi.org/10.1113/jp274948