Výsledky vyhledávání - "Loren M. LaPointe"

The FtsLB subcomplex of the bacterial divisome is a tetramer with an uninterrupted FtsL helix linking the transmembrane and periplasmic regions

Autor: Alessandro Senes, Janice L. Robertson, Rahul Chadda, John A. Crooks, Loren M. LaPointe, Deena Al Mahbuba, Ambalika S. Khadria, Samson G.F. Condon, Aaron A. Hoskins, Gladys Diaz-Vazquez, Douglas B. Weibel, Samuel J. Craven, Qiang Cui, Claire R. Armstrong, Nambirajan Rangarajan

Publikováno v: Journal of Biological Chemistry. 293:1623-1641

In Escherichia coli, FtsLB plays a central role in the initiation of cell division, possibly transducing a signal that will eventually lead to the activation of peptidoglycan remodeling at the forming septum. The molecular mechanisms by which FtsLB o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1764c3c03e81dcac0e47fad7a61ab0
https://doi.org/10.1074/jbc.ra117.000426

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Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes

Autor: Frits Kamp, Edith Winkler, Loren M. LaPointe, Holger A. Scheidt, Daniel Huster, James M. Hutchison, Gabriele Basset, Hannes Heinel, Harald Steiner, Charles R. Sanders

Publikováno v: ACS chemical neuroscience 9(7), 1702-1713 (2018). doi:10.1021/acschemneuro.8b00068

Bexarotene is a pleiotropic molecule that has been proposed as an amyloid-β (Aβ)-lowering drug for the treatment of Alzheimer´s disease (AD). It acts by upregulation of an apolipoprotein E (apoE)-mediated Aβ clearance mechanism. However, whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9612a89eb1ab17aa99a01b0561a185f6
https://pubmed.ncbi.nlm.nih.gov/29717863

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The Oligomeric States of the Purified Sigma-1 Receptor Are Stabilized by Ligands*

Autor: Katarzyna A. Gromek, Fabian P. Suchy, Russell L. Wrobel, Hannah Meddaugh, Arnold E. Ruoho, Brian G. Fox, Loren M. LaPointe, Uyen B. Chu, Alessandro Senes, John G. Primm

Publikováno v: The Journal of Biological Chemistry

Background: Sigma-1 receptor (S1R) is an integral membrane ligand-binding receptor. Results: Gel filtration chromatography revealed oligomeric states that are stabilized by ligand binding and destabilized by mutations in the GXXXG integral membrane d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9442d8d7603c5aeb7db2743fb650bb18
http://europepmc.org/articles/PMC4106346

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Structural organization of FtsB, a transmembrane protein of the bacterial divisome

Autor: Ivan Rayment, Alessandro Senes, Ambalika S. Khadria, Loren M. LaPointe, Keenan C. Taylor, Sabareesh Subramaniam

Publikováno v: Biochemistry. 52(15)

We report the first structural analysis of an integral membrane protein of the bacterial divisome. FtsB is a single-pass membrane protein with a periplasmic coiled coil. Its heterologous association with its partner FtsL represents an essential event

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42c463d0895aa09a06a022058f73ac5
https://pubmed.ncbi.nlm.nih.gov/23520975

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Biophysical Characterization of the FtsL/B Subcomplex of the Bacterial Divisom

Autor: Loren M. LaPointe

Publikováno v: Biophysical Journal. (3):473a

Cell division in the gram-negative bacterium Escherichia coli is carried out through the cooperative assembly of at least 10 required proteins, known as the divisome. Few divisome proteins have described functions, and the structural details of their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade604afe61723a5cd6da7f4e0fad7c7

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