Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Loren M, Brown"'
Autor:
Thanh N. Dang, Rafael P. Tiongco, Loren M. Brown, Jessica L. Taylor, John M. Lyons, Frank H. Lau, Z. Elizabeth Floyd
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background Well-differentiated and dedifferentiated liposarcomas are rare soft tissue tumors originating in adipose tissue that share genetic abnormalities but have significantly different metastatic potential. Dedifferentiated liposarcoma (
Externí odkaz:
https://doaj.org/article/623082395c62446887c606a0e448899f
Autor:
Rakesh Gurrala, C. Ethan Byrne, Loren M. Brown, Rafael Felix P. Tiongco, Margarite D. Matossian, Jonathan J. Savoie, Bridgette M. Collins-Burow, Matthew E. Burow, Elizabeth C. Martin, Frank H. Lau
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Solid tumor progression is significantly influenced by interactions between cancer cells and the surrounding extracellular matrix (ECM). Specifically, the cancer cell-driven changes to ECM fiber alignment and collagen deposition impact tumor growth a
Externí odkaz:
https://doaj.org/article/637f077b8cbc477aab64cef45f097cfd
Autor:
Katarina Klepac, Ana Kilić, Thorsten Gnad, Loren M. Brown, Beate Herrmann, Andrea Wilderman, Aileen Balkow, Anja Glöde, Katharina Simon, Martin E. Lidell, Matthias J. Betz, Sven Enerbäck, Jürgen Wess, Marc Freichel, Matthias Blüher, Gabi König, Evi Kostenis, Paul A. Insel, Alexander Pfeifer
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Brown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice
Externí odkaz:
https://doaj.org/article/7a2bc9f5eaee4df68bf0b1b7a219eba3
Autor:
Katherine Hebert, Bridgette M. Collins-Burow, Loren M. Brown, Frank H. Lau, Matthew E. Burow, Madlin Alzoubi, Margarite D. Matossian, Khoa Nguyen
Publikováno v:
Cancer Research. 81:PS8-20
Breast cancer (BC) is among the most commonly diagnosed cancers in women and is the leading cause of malignant death in U.S. women. The triple negative breast cancer (TNBC) subtype is more aggressive and has a poorer prognosis compared to other subty
Autor:
Elizabeth C. Martin, Loren M. Brown, Katherine Hebert, C. Ethan Byrne, Rakesh Gurrala, Frank H. Lau, Matthew E. Burow
Publikováno v:
Journal of visualized experiments : JoVE. (170)
Breast cancer (BC) remains a leading cause of death for women. Despite more than $700 million invested in BC research annually, 97% of candidate BC drugs fail clinical trials. Therefore, new models are needed to improve our understanding of the disea
Publikováno v:
Journal of Molecular and Cellular Cardiology. 121:51-59
In cardiac myocytes activation of an exchange factor activated by cAMP (Epac) leads to activation of phospholipase Cε (PLCε)-dependent hydrolysis of phosphatidylinositol 4-phosphate (PI4P) in the Golgi apparatus a process critical for development o
Autor:
C. Ethan Byrne, Loren M. Brown, Elizabeth C. Marrin, Frank H. Lau, Rakesh Gurrala, Rafael Felix P. Tiongco
Publikováno v:
Journal of the American College of Surgeons. 233:e11
Publikováno v:
The FASEB Journal. 33
Autor:
Marc Freichel, Evi Kostenis, Katharina Simon, Ana Kilić, Beate Herrmann, Matthias Blüher, Loren M. Brown, Aileen Balkow, Martin E. Lidell, Thorsten Gnad, Sven Enerbäck, Katarina Klepac, Alexander Pfeifer, Jürgen Wess, Paul A. Insel, Matthias J. Betz, Andrea Wilderman, Gabi König, Anja Glöde
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications
Brown adipose tissue (BAT) dissipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates with leanness in human adults. Here we profile G protein-coupled receptors (GPCRs) in brown adipocytes to identify drugga
Publikováno v:
Journal of Biological Chemistry. 289:29148-29157
Epac, a guanine nucleotide exchange factor for the low molecular weight G protein Rap, is an effector of cAMP signaling and has been implicated to have roles in numerous diseases, including diabetes mellitus, heart failure, and cancer. We used a comp