Cardiac engraftment of genetically-selected parthenogenetic stem cell-derived cardiomyocytes.

Autor: Tao Yang, Michael Rubart, Mark H Soonpaa, Michael Didié, Peter Christalla, Wolfram-Hubertus Zimmermann, Loren J Field

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0131511 (2015)

Parthenogenetic stem cells (PSCs) are a promising candidate donor for cell therapy applications. Similar to embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), PSCs exhibit self-renewing capacity and clonogenic proliferation in vi

Externí odkaz: https://doaj.org/article/d171af37d36144aea209eadf6476deb4

Lineage tracing of cardiac explant derived cells.

Autor: Lincoln T Shenje, Loren J Field, Catrin A Pritchard, Christopher J Guerin, Michael Rubart, Mark H Soonpaa, Keng-Leong Ang, Manuel Galiñanes

Publikováno v: PLoS ONE, Vol 3, Iss 4, p e1929 (2008)

Cultured cardiac explants produce a heterogeneous population of cells including a distinctive population of refractile cells described here as small round cardiac explant derived cells (EDCs). The aim of this study was to explore the source, morpholo

Externí odkaz: https://doaj.org/article/993c4e93a7f24493841753436f9a0374

Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase

Autor: Marc R. Reboll, Stefanie Klede, Manuel H. Taft, Chen-Leng Cai, Loren J. Field, Kory J. Lavine, Andrew L. Koenig, Jenni Fleischauer, Johann Meyer, Axel Schambach, Hans W. Niessen, Maike Kosanke, Joop van den Heuvel, Andreas Pich, Johann Bauersachs, Xuekun Wu, Linqun Zheng, Yong Wang, Mortimer Korf-Klingebiel, Felix Polten, Kai C. Wollert

Publikováno v: Reboll, M R, Klede, S, Taft, M H, Cai, C-L, Field, L J, Lavine, K J, Koenig, A L, Fleischauer, J, Meyer, J, Schambach, A, Niessen, H W, Kosanke, M, van den Heuvel, J, Pich, A, Bauersachs, J, Wu, X, Zheng, L, Wang, Y, Korf-Klingebiel, M, Polten, F & Wollert, K C 2022, ' Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase ', Science, vol. 376, no. 6599, pp. 1343-1347 . https://doi.org/10.1126/science.abn3027
Science, 376(6599), 1343-1347. American Association for the Advancement of Science

Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell–endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ad5532374bacfed516c0ac7506067c
https://pubmed.ncbi.nlm.nih.gov/36544808

HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure

Autor: Rajani M. George, Ronald M Payne, Loren J. Field, Hongyu Gao, Michael Rubart-von der Lohe, Weinian Shou, Anthony B. Firulli, Wenjun Zhang, Jade Harkin, Beth A. Firulli, Ying Liu, Kevin P. Toolan, Yunlong Liu

Publikováno v: Cardiovasc Res

AimsTo examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in embryonic and adult myocardium.Methods and resultsHand1 is expressed within the cardiomyocytes of the left ventricle (LV) and myocardial cuff between embryonic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4eb9e7a7d5a88d1eee42c91a0d485c
https://doi.org/10.1093/cvr/cvz182

Abstract 12627: I Na Remodeling and Conduction Deficits in a Murine Model of Human LMNA -R545H Mutation

Autor: Loren J. Field, Peng Sheng Chen, Katie G. Spoonamore, Zhenhui Chen, Thomas H. Everett, Tomohiko Ai, Michael Rubart, Adonis Z. Wu, Matteo Vatta, Cheng Wang

Publikováno v: Circulation. 142

Introduction: We have identified a de novo mutation of LMNA ( LMNA -R545H) in a 34-year-old man with high-grade atrioventricular block. Studies in HEK-293 cells showed that LMNA -R545H reduced the amplitude and resulted in a shift in gating kinetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16d74bc35f10a08f101f2e72dc00a715
https://doi.org/10.1161/circ.142.suppl_3.12627