Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Loren B, Andreas"'
Autor:
Marcel C. Forster, Kumar Tekwani Movellan, Eszter E. Najbauer, Stefan Becker, Loren B. Andreas
Publikováno v:
Journal of Structural Biology: X, Vol 9, Iss , Pp 100098- (2024)
Here we report the structure of Opa60 in lipid bilayers using proton-detected magic-angle spinning nuclear magnetic resonance (MAS NMR). Preparations including near-native oligosaccharide lipids reveal a consistent picture of a stable transmembrane b
Externí odkaz:
https://doaj.org/article/9b5ab73b4868401ca4f03f07d442897b
Autor:
Benedikt Frieg, Mookyoung Han, Karin Giller, Christian Dienemann, Dietmar Riedel, Stefan Becker, Loren B. Andreas, Christian Griesinger, Gunnar F. Schröder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Alzheimer’s disease (AD) is a progressive and incurable neurodegenerative disease characterized by the extracellular deposition of amyloid plaques. Investigation into the composition of these plaques revealed a high amount of amyloid-β (A
Externí odkaz:
https://doaj.org/article/f12a70bcf0274200ae54e24f2672d1af
Publikováno v:
JACS Au, Vol 3, Iss 10, Pp 2763-2771 (2023)
Externí odkaz:
https://doaj.org/article/b7952d1cf8a3460596e5823537f01bbc
Autor:
Pijush Chakraborty, Gwladys Rivière, Alina Hebestreit, Alain Ibáñez de Opakua, Ina M. Vorberg, Loren B. Andreas, Markus Zweckstetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Pathogenic aggregation of the protein tau is a hallmark of Alzheimer’s disease and several other tauopathies. Tauopathies are characterized by the deposition of specific tau isoforms as disease-related tau filament structures. The molecula
Externí odkaz:
https://doaj.org/article/77f6a7aa40ff49099ccf224aed75385a
Autor:
Kumar Tekwani Movellan, Melanie Wegstroth, Kerstin Overkamp, Andrei Leonov, Stefan Becker, Loren B. Andreas
Publikováno v:
Journal of Structural Biology: X, Vol 8, Iss , Pp 100090- (2023)
The drug Rimantadine binds to two different sites in the M2 protein from influenza A, a peripheral site and a pore site that is the primary site of efficacy. It remained enigmatic that pore binding did not occur in certain detergent micelles, and in
Externí odkaz:
https://doaj.org/article/6126c5d4268f427484adf5d7d99bc435
Autor:
Benedikt Frieg, Leif Antonschmidt, Christian Dienemann, James A. Geraets, Eszter E. Najbauer, Dirk Matthes, Bert L. de Groot, Loren B. Andreas, Stefan Becker, Christian Griesinger, Gunnar F. Schröder
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Interactions between α-synuclein fibrils and lipids have been associated with the development of Parkinson’s disease. This cryo-EM study reveals structural details of these interactions and suggests a mechanism for fibril-induced lipid extraction.
Externí odkaz:
https://doaj.org/article/370fbaf8c903466ab28670a017457f67
Autor:
Leif Antonschmidt, Dirk Matthes, Rıza Dervişoğlu, Benedikt Frieg, Christian Dienemann, Andrei Leonov, Evgeny Nimerovsky, Vrinda Sant, Sergey Ryazanov, Armin Giese, Gunnar F. Schröder, Stefan Becker, Bert L. de Groot, Christian Griesinger, Loren B. Andreas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Understanding how small molecules bind to pathological aggregates is of importance for therapeutic and diagnostic development in diseases such as Parkinson’s Disease. Here, the authors reveal a binding site of anle138b to lipid-induced α-synuclein
Externí odkaz:
https://doaj.org/article/ed3eab20b6124a5585faf679ec466929
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The permeability barrier of nuclear pores is formed by disordered and yet self-interacting FG repeat domains, whose sequence heterogeneity is a challenge for mechanistic insights. Here the authors overcome this challenge and characterize the protein
Externí odkaz:
https://doaj.org/article/bf9aa8c07e364d5b96c32a1286a5d4dd
Autor:
Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B. Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Toft-Bertelsen et al. describe repurposing of anti-influenza drug amantadine and its derivatives for the treatment of SARS-CoV-2. They show that Amantadine, Emodin and Xanthene show significant blockage of ionchannels formed by SARS-CoV-2 which are c
Externí odkaz:
https://doaj.org/article/f7013bc495364bc4bcb0878e0dba41ad
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/8bb7b1bbd2dc4c099259d492b8d872fe