Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Lorella, Marselli"'
Autor:
Goutham Atla, Silvia Bonàs-Guarch, Mirabai Cuenca-Ardura, Anthony Beucher, Daniel J. M. Crouch, Javier Garcia-Hurtado, Ignasi Moran, the T2DSystems Consortium, Manuel Irimia, Rashmi B. Prasad, Anna L. Gloyn, Lorella Marselli, Mara Suleiman, Thierry Berney, Eelco J. P. de Koning, Julie Kerr-Conte, Francois Pattou, John A. Todd, Lorenzo Piemonti, Jorge Ferrer
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-28 (2022)
Abstract Background Non-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. For many loci, however,
Externí odkaz:
https://doaj.org/article/cf1281e02aac42cea7c15b4711ce5611
Autor:
Giuseppina E. Grieco, Noemi Brusco, Daniela Fignani, Laura Nigi, Caterina Formichi, Giada Licata, Lorella Marselli, Piero Marchetti, Laura Salvini, Laura Tinti, Agnese Po, Elisabetta Ferretti, Guido Sebastiani, Francesco Dotta
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract The loss of functional β-cell mass in type 2 diabetes (T2D) is associated with molecular events that include β-cell apoptosis, dysfunction and/or dedifferentiation. MicroRNA miR-184-3p has been shown to be involved in several β-cell funct
Externí odkaz:
https://doaj.org/article/bb8692b30fd94777a15b946bb1a698f1
Autor:
Peng Xiao, Tatiana Takiishi, Natalia Moretti Violato, Giada Licata, Francesco Dotta, Guido Sebastiani, Lorella Marselli, Sumeet Pal Singh, Mozes Sze, Geert Van Loo, Emmanuel Dejardin, Esteban Nicolas Gurzov, Alessandra Kupper Cardozo
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-11 (2022)
Abstract The transcription factor nuclear factor-κB (NF-κB) has a key role in the pathogenesis of diabetes and its complications. Although activation of the canonical NF-κB pathway in β-cells is generally deleterious, little is known about the ro
Externí odkaz:
https://doaj.org/article/1277c1357f0c4eb8aed8ef4ecac0ad73
Autor:
Itziar González-Moro, Henar Rojas-Márquez, Maialen Sebastian-delaCruz, Jon Mentxaka-Salgado, Ane Olazagoitia-Garmendia, Luis Manuel Mendoza, Aina Lluch, Federica Fantuzzi, Carmen Lambert, Jessica Ares Blanco, Lorella Marselli, Piero Marchetti, Miriam Cnop, Elías Delgado, José Manuel Fernández-Real, Francisco José Ortega, Ainara Castellanos-Rubio, Izortze Santin
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionMost of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions of the human genome. Many of these variants have been predicted to impact the expression and function of long non-coding RNAs (lncRNA), but t
Externí odkaz:
https://doaj.org/article/ebe17607831f49a7867679d95c1d4143
Autor:
Xiaoyan Yi, Bianca Marmontel de Souza, Toshiaki Sawatani, Florian Szymczak, Lorella Marselli, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105376- (2022)
Summary: Target tissues of autoimmune and degenerative diseases show signals of inflammation. We used publicly available RNA-seq data to study whether pancreatic β-cells in type 1 and type 2 diabetes and neuronal tissue in multiple sclerosis and Alz
Externí odkaz:
https://doaj.org/article/98968df14f8745248b90aa1ddd003817
Autor:
Lisa Stoll, Adriana Rodríguez-Trejo, Claudiane Guay, Flora Brozzi, Mustafa Bilal Bayazit, Sonia Gattesco, Véronique Menoud, Jonathan Sobel, Ana Claudia Marques, Morten Trillingsgaard Venø, Jonathan Lou S. Esguerra, Mohammad Barghouth, Mara Suleiman, Lorella Marselli, Jørgen Kjems, Lena Eliasson, Erik Renström, Karim Bouzakri, Michel Pinget, Piero Marchetti, Romano Regazzi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Circular RNAs contribute to the regulation of β-cell specific functions. Here the authors show that a circular RNA derived from one of the introns of the insulin gene is necessary for optimal insulin secretion from pancreatic islets and that its lev
Externí odkaz:
https://doaj.org/article/114bb60757e446fba74489bec09b7aca
Autor:
Maria Lytrivi, Kassem Ghaddar, Miguel Lopes, Victoria Rosengren, Anthony Piron, Xiaoyan Yi, Henrik Johansson, Janne Lehtiö, Mariana Igoillo-Esteve, Daniel A. Cunha, Lorella Marselli, Piero Marchetti, Henrik Ortsäter, Decio L. Eizirik, Miriam Cnop
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background Prolonged exposure to elevated free fatty acids induces β-cell failure (lipotoxicity) and contributes to the pathogenesis of type 2 diabetes. In vitro exposure of β-cells to the saturated free fatty acid palmitate is a valuable
Externí odkaz:
https://doaj.org/article/00865dcdc6ad4d628c3c9db3fbad1e00
Autor:
Gianmarco Ferri, Marta Tesi, Federico Massarelli, Lorella Marselli, Piero Marchetti, Francesco Cardarelli
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 7, Pp 409-418 (2020)
Abstract A cascade of highly regulated biochemical processes connects glucose stimulation to insulin secretion in specialized cells of mammalian pancreas, the β‐cells. Given the importance of this process for systemic glucose homeostasis, noninvas
Externí odkaz:
https://doaj.org/article/6232d8630f594743bc336672a4ca00c9
Autor:
Maikel L. Colli, Mireia Ramos-Rodríguez, Ernesto S. Nakayasu, Maria I. Alvelos, Miguel Lopes, Jessica L. E. Hill, Jean-Valery Turatsinze, Alexandra Coomans de Brachène, Mark A. Russell, Helena Raurell-Vila, Angela Castela, Jonàs Juan-Mateu, Bobbie-Jo M. Webb-Robertson, Lars Krogvold, Knut Dahl-Jorgensen, Lorella Marselli, Piero Marchetti, Sarah J. Richardson, Noel G. Morgan, Thomas O. Metz, Lorenzo Pasquali, Décio L. Eizirik
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The cytokine IFNα is expressed in the islets of individuals with type 1 diabetes and contributes to local inflammation and destruction of beta cells. Here, the authors provide a global multiomics view of IFNα-induced changes in human beta cells at
Externí odkaz:
https://doaj.org/article/7ba57ffc94954c2897c0cf413d87e02a
Autor:
Laura Nigi, Noemi Brusco, Giuseppina E. Grieco, Daniela Fignani, Giada Licata, Caterina Formichi, Elena Aiello, Lorella Marselli, Piero Marchetti, Lars Krogvold, Knut Dahl Jorgensen, Guido Sebastiani, Francesco Dotta
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The interaction between genetic and environmental factors determines the development of type 1 diabetes (T1D). Some viruses are capable of infecting and damaging pancreatic β-cells, whose antiviral response could be modulated by specific viral RNA r
Externí odkaz:
https://doaj.org/article/67f9b5bf3fe54c098f476eb3ceaf9c43