Analysis of alpha‐1‐antitrypsin (AAT)‐regulated, glucocorticoid receptor‐dependent genes in macrophages reveals a novel host defense function of AAT

Autor: Xiyuan Bai, Junfeng Gao, Xiaoyu Guan, Drew E. Narum, Lorelenn B. Fornis, David E. Griffith, Bifeng Gao, Robert A. Sandhaus, Hua Huang, Edward D. Chan

Publikováno v: Physiological Reports, Vol 12, Iss 14, Pp n/a-n/a (2024)

Abstract Alpha‐1‐antitrypsin (AAT) plays a homeostatic role in attenuating excessive inflammation and augmenting host defense against microbes. We demonstrated previously that AAT binds to the glucocorticoid receptor (GR) resulting in significant

Externí odkaz: https://doaj.org/article/cd36fff562424506b50b4589d90ee722

Author Correction: Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19

Autor: Xiyuan Bai, Ashley M. Buckle, Eszter K. Vladar, Edward N. Janoff, Reeti Khare, Diane Ordway, David Beckham, Lorelenn B. Fornis, Abraham Majluf-Cruz, Randolph V. Fugit, Brian M. Freed, Soohyun Kim, Robert A. Sandhaus, Edward D. Chan

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-2 (2022)

Externí odkaz: https://doaj.org/article/00ca77f49f1541f1b75658582a402a13

Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19.

Autor: Bai, Xiyuan^1,2,3,4 (AUTHOR) BaiX@NJHealth.org, Buckle, Ashley M.⁵ (AUTHOR), Vladar, Eszter K.³ (AUTHOR), Janoff, Edward N.^1,6 (AUTHOR), Khare, Reeti⁷ (AUTHOR), Ordway, Diane⁸ (AUTHOR), Beckham, David⁶ (AUTHOR), Fornis, Lorelenn B.² (AUTHOR), Majluf-Cruz, Abraham⁹ (AUTHOR), Fugit, Randolph V.¹⁰ (AUTHOR), Freed, Brian M.¹¹ (AUTHOR), Kim, Soohyun^12,13 (AUTHOR), Sandhaus, Robert A.² (AUTHOR), Chan, Edward D.^1,2,3,4 (AUTHOR) ChanE@NJHealth.org

Publikováno v: Scientific Reports. 4/19/2022, Vol. 12 Issue 1, p1-14. 14p.