A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease

Autor: Margaret Marie Cox, Stephanie Sendek, Margaret F. Turk, Julie H. Carter, Susan C. Fagan, Lorelei Derwent, Oksana Suchowersky, Jay S. Schneider, Linda Paul, Gwyn Vernon, Stephen Gollomp, Karl Kieburtz, Debbie Baker, I. Van Bodis-Wollner, Germaine McInnes, Marian A. Perez, G. Webster Ross, Katharine Pabst, Jorge L. Juncos, Chad W. Christine, Jessie Roth, Joseph M. Savitt, Peter A LeWitt, Hubert H. Fernandez, Matthew Brodsky, Mark F. Lew, Jay M. Gorell, Natividad R. Stover, Paulo Guimaraes, Andrew Feigin, Anita Blenke, Martha Nance, Elizabeth Hayes, Andrew Siderowf, W.R. Wayne Martin, Tammie Kelsey, Susan Bennett, Sharon McCarthy, Charles H. Adler, Beverly Olsen, Pauline LeBlanc, Richard B. Dewey, Rodger J. Elble, Richard S. Burns, Carlos Singer, Amy Parsons, John W. Taylor, Tracy Stewart, Maryan DeAngelis, Barbara C. Tilley, William J. Weiner, Brad A. Racette, Wendy R. Galpern, Michael J. Aminoff, Kapil D. Sethi, Jayaraman Rao, Robert A. Hauser, Debbie Fraser, Connie Kawai, David Coffey, Kelly E. Lyons, Kristine Wernette, Becky Dunlop, Holly Delgado, Marlene Lind, Rajesh Pahwa, Chris Weaver, Ray L. Watts, Patricia Deppen, Ryan J. Uitti, Marwan N. Sabbagh, Lynn Marlor, Joann Belden, Burton L. Scott, Theresa McClain, Roger L. Albin, John Y. Fang, Zoran Obradov, Yuko Y. Palesch, Maureen Cook, Pamela Andrews, Jeana Jaglin, Joanne Wojcieszek, Mary Louise Musante Weeks, Susan Peterson, James H. Bower, Maureen A. Leehey, Joanne Field, Lisa M. Shulman, Caroline M. Tanner, Jacob I. Sage, Jordan J. Elm, Joseph Jankovic, Patrick D. Mauldin, Aileen Shinaman, Peng Huang, G. Frederick Wooten, Alicia Brocht, Gordon H. Brown, Peggy Roberge, Dorothy Shearon, Buff Dill, Margaret F. Keller, Charlene Young, Christine Hunter, Janis M. Miyasaki, Susan Torgrimson, Cornelia Kamp, Brigid Hayward, Christopher G. Goetz, Emily Kosa, Marilyn Flewellen, David Simon, Rebecca McMurray, Sue Reichwein, Jacci Bainbridge, Robert W. Hamill, Stephanie Terashita, Kathleen M. Shannon, Frederick Wooten, Danna Jennings, Shana Krstevska, Bernard Ravina

Publikováno v: Neurology. 68:20-28

Objective: To determine if future studies of coenzyme Q10 and GPI-1485 in Parkinson disease (PD) may be warranted. Methods: We conducted a randomized, double-blind, calibrated futility clinical trial of coenzyme Q10 and GPI-1485 in early untreated PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f17ff7b2eee66f71cf67f7561841fe
https://doi.org/10.1212/01.wnl.0000250355.28474.8e

Effect of Creatine Monohydrate on Clinical Progression in Patients With Parkinson Disease

Autor: Lorelei Derwent, Chadwick W. Christine, Alicia H. Augustine, Zoltan Mari, Richard B. Dewey, Jessie Roth, Maureen A. Leehey, Kelvin L. Chou, Nabila Dahodwala, Sheng Luo, Sotirios A. Parashos, Katherine B. Hawthorne, Caroline M. Tanner, Franca Cambi, Helen Petrovitch, Karl Kieburtz, Mark F. Lew, Suja S. Rajan, Jay S. Schneider, Jordan J. Elm, Carlos Singer, Michelle Cines, James T. Boyd, Ivan Bodis-Wollner, G. Webster Ross, Karen Williams, Chizoba C. Umeh, Michael J. Aminoff, David J. Houghton, Grace S. Liang, Cornelia Kamp, Lewis Sudarsky, Barbara C. Tilley, Robert A. Hauser, Debra Babcock, John C. Morgan, Erika U. Augustine, Adriana Pérez, Kathleen M. Shannon, David Simon, Tanya Simuni, Sue Reichwein, Anne-Marie Wills

Publikováno v: JAMA. 313:584

Importance There are no treatments available to slow or prevent the progression of Parkinson disease, despite its global prevalence and significant health care burden. The National Institute of Neurological Disorders and Stroke Exploratory Trials in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef36ee0e298e8b880bfb48367249ed54
https://doi.org/10.1001/jama.2015.120

A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease

Autor: Diane Cote, Jeri Sieren, Alex Rajput, James W. Tetrud, Paul J. Tuite, Christopher T. Ingvoldstad, Cheryl Waters, Shari Niswonger, Roger Kurlan, David D. Song, Jennifer Young, Samuel Markind, Alicia Palao, Munira Sultana, Christine Hunter, Karen Williams, Sandra K. Kostyk, John G. Nutt, Andrew Feigin, Dragos Mihaila, Karen Blindauer, Abraham Lieberman, Annette Robinson, Adrienna Winters, Michelle Cines, Mattson Ogg, Robert A. Hauser, Ira Shoulson, Julia Spears, Jorge L. Juncos, William G. Ondo, David Simon, Mark Stacy, Stacy Merritt, Barbara Shannon, Un Jung Kang, Katie Kompoliti, Cheryl Deeley, Joanne Field, Arthur Watts, Buff Farrow, Karen Helles, Katharine Smith, Karen Thomas, Rajan Prakash, Joel S. Perlmutter, Rajeev Kumar, Mandar Jog, Pamela King, Neal Hermanowicz, Stephen G. Reich, Mark Chilton, Lawrence Severt, Vanessa K. Hinson, Kapil D. Sethi, Mark F. Lew, Pinky Agarwal, Clifford M Shults, Natividad Stover, Richard H. Haas, Jayaraman Rao, Thomas Mayer, Thyagarajan Subramanian, Althea Silver, Richard M. Zweig, Lin Zhang, Hubert H. Fernandez, Linda Cole, Charles H. Adler, Jean Rivest, Marye Kellermann, Marlene Lind, Stephanie Wilson, Jennifer Conway, Ray L. Watts, Monica Beland, Joseph H. Friedman, Michael S. Okun, Maureen Cook, Stephen Grill, Cindy Zadikoff, Irene Litvan, Donna Stuppy Ford, Karen Frei, L Pepper Lumina, David Grimes, Sofya Glazman, Edward Drasby, Wendy R. Galpern, Susan Rolandelli, Sharon Evans, Bernard Ravina, Robert W. Hamill, Jo Bergholte, Andrew Siderowf, W.R. Wayne Martin, Rajesh Pahwa, Sanja Obradov, April Langhammer, Lorelei Derwent, Barbara Sommerfeld, M. Flint Beal, Alok Sahay, Anita Blenke, Liza Reys, Melisa Pelikan, Amy Duffy, Holly A. Shill, Eric Molho, Ivan Bodis-Wollner, Candace Cotto, Marilyn Cowper, Marian L. Evatt, Ani Arkun, Johanna M Hartlein, Nancy Zappala, Clara Schindler Propsom, Matthew Brodsky, Colette Lynn Hilliard, Stephanie Lessig, Stephanie Guthrie, Joanne Wojcieszek, Deborah Fontaine, Irene H. Richard, Zoltan Mari, Kathy Davis, Carlos Singer, Samuel A. Ellias, Lawrence Elmer, Julie So, Louisette Bond, Janis M. Miyasaki, Camille Swartz, Ranjit Ranawaya, Brian Griebner, Ramon L. Rodriguez, Ronald F. Pfeiffer, Becky Dunlop, David Oakes, Michel Panisset, Tiffini Voss, Joohi Jimenez-Shahed, Karyn Boyar, Cathi-Ann Thomas, Victoria Snively, Claire Henchcliffe, Margaret C. Lannon, Maureen Gartner, Cherissa Sia, Maureen A. Leehey, Joan Young, Anwar Ahmed, David S. Russell, Melissa J. Nirenberg, Emmanuelle Pourcher, James T. Boyd, Lauren Kraics, Ted M. Dawson, Ergun Y. Uc, Shan Gao, Angel Figueroa

Publikováno v: JAMA Neurology. 71:543

Importance Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe and well tolerated in early-phase human studies. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbaa699332e1164a6e43ffbb175898c5
https://doi.org/10.1001/jamaneurol.2014.131

A new quantitative method for evaluating freezing of gait and dual-attention task deficits in Parkinson's disease.

Autor: Chomiak, Taylor, Pereira, Fernando, Meyer, Nicole, Bruin, Natalie, Derwent, Lorelei, Luan, Kailie, Cihal, Alexandra, Brown, Lesley, Hu, Bin

Publikováno v: Journal of Neural Transmission; Nov2015, Vol. 122 Issue 11, p1523-1531, 9p

Front Matter.

Autor: Jonsson, Egon, Martin, Wayne, Suchowersky, Oksana, Kovacs Burns, Katharina

Publikováno v: Parkinson Disease: A Health Policy Perspective; 2010, pI-XXIII, 22p