Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lorela Paco"'
Publikováno v:
Biochemistry. 59(33)
Aromatase (CYP19A1) catalyzes the synthesis of estrogens from androgens and is an invaluable target of pharmacotherapy for estrogen-dependent cancers. CYP19A1 is also one of the most primordial human CYPs and, to the extent that its fundamental dynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888f0254709f2a243df2a404eb41ae7d
https://pubmed.ncbi.nlm.nih.gov/32786398
https://pubmed.ncbi.nlm.nih.gov/32786398
Autor:
Katherine A. Sitko, Allan E. Rettie, Maitreya J. Dunham, Rheem A. Totah, Byron Gallis, Abhinav Nath, John P. Kowalski, Lorela Paco, Sutapa Ray, Matthew G. McDonald, Douglas M. Fowler, Clara J. Amorosi
Publikováno v:
Drug Metabolism and Disposition. 45:1364-1371
CYP4Z1 is an "orphan" cytochrome P450 (P450) enzyme that has provoked interest because of its hypothesized role in breast cancer through formation of the signaling molecule 20-hydroxyeicosatetraenoic acid (20-HETE). We expressed human CYP4Z1 in Sacch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7a38e1b612a701f0f2c760f61bbaaab
https://doi.org/10.1124/dmd.117.078188
https://doi.org/10.1124/dmd.117.078188
Autor:
Matthew G, McDonald, Sutapa, Ray, Clara J, Amorosi, Katherine A, Sitko, John P, Kowalski, Lorela, Paco, Abhinav, Nath, Byron, Gallis, Rheem A, Totah, Maitreya J, Dunham, Douglas M, Fowler, Allan E, Rettie
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 45(12)
CYP4Z1 is an “orphan” cytochrome P450 (P450) enzyme that has provoked interest because of its hypothesized role in breast cancer through formation of the signaling molecule 20-hydroxyeicosatetraenoic acid (20-HETE). We expressed human CYP4Z1 in S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f7d028e1733140bdf09ba5e31751df1d
https://pubmed.ncbi.nlm.nih.gov/29018033
https://pubmed.ncbi.nlm.nih.gov/29018033
Cytochrome P4503A4 (CYP3A4) is a peripheral membrane protein that plays a major role in enzymatic detoxification of many drugs and toxins. CYP3A4 has an integral membrane N-terminal helix and a localized patch comprised of the G′ and F′ helix reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53bc06794fa29129927781fb341e9a9
https://europepmc.org/articles/PMC5275761/
https://europepmc.org/articles/PMC5275761/
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 329 (2023)
High concentrations of electrophilic lipid alkenals formed during oxidative stress are implicated in cytotoxicity and disease. However, low concentrations of alkenals are required to induce antioxidative stress responses. An established clearance pat
Externí odkaz:
https://doaj.org/article/e270b1016b824c80bcc9e3e37b0b99f2