Výsledky vyhledávání - "Loredana Serafini"

Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition

Autor: Justin D. Lutz, Ting Wang, Roman Sakowicz, Weimei Xing, Adrian S. Ray, Gregg Czerwieniec, Albert Liclican, Bart Steiner, Kathleen S. Keegan, Joy Y. Feng, Katherine M. Brendza, Brian E. Schultz, Loredana Serafini

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1864:129531

Background Bruton's tyrosine kinase (BTK) is a key component of the B-cell receptor (BCR) pathway and a clinically validated target for small molecule inhibitors such as ibrutinib in the treatment of B-cell malignancies. Tirabrutinib (GS-4059/ONO-405

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b69ffb686f51e068fb4304ec4a8321
https://doi.org/10.1016/j.bbagen.2020.129531

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The proteomic response of sea squirts (genus Ciona congeners) to heat stress: Evidence for differential thermal sensitivities

Autor: Loredana Serafini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ac093db00c43c9ef6daf66df7ad01d5
https://doi.org/10.15368/theses.2011.1

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The proteomic response of sea squirts (genus Ciona) to acute heat stress: A global perspective on the thermal stability of proteins

Autor: Dietmar Kültz, Lars Tomanek, Jay B. Hann, Loredana Serafini

Publikováno v: Comparative Biochemistry and Physiology Part D: Genomics and Proteomics. 6:322-334

Congeners belonging to the genus Ciona have disparate distributions limited by temperature. Ciona intestinalis is more widespread with a cosmopolitan distribution ranging from tropical to sub-arctic zones, while Ciona savignyi is limited to temperate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5882d1fa7a9d487f43ce7a304cf07bc4
https://doi.org/10.1016/j.cbd.2011.07.002

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Biochemical Characterization of GS-4059 As a Potent and Selective Covalent Irreversible Inhibitor of Bruton's Tyrosine Kinase

Autor: Weimei Xing, Justin D. Lutz, Brian E. Schultz, Roman Sakowicz, Adrian S. Ray, Loredana Serafini, Ting Wang, Albert Liclican, Joy Y. Feng, Kathy Brendza

Publikováno v: Blood. 128:1594-1594

Introduction:Bruton's tyrosine kinase (BTK) plays a crucial role in B-cell development, differentiation, and signaling in the B-cell receptor (BCR) signaling pathway, and is a validated target for aberrant B-cell activity in malignancy and autoimmune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46eff87484d45aa5751dc2bc2d831f0f
https://doi.org/10.1182/blood.v128.22.1594.1594

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Proteomics of hyposaline stress in blue mussel congeners (genus Mytilus): implications for biogeographic range limits in response to climate change

Autor: Lauren Rachelle Hitt, Marcus J. Zuzow, Loredana Serafini, Lars Tomanek, Jacob J. Valenzuela

Publikováno v: The Journal of experimental biology. 215(Pt 22)

Climate change is affecting species' physiology, pushing environmental tolerance limits and shifting distribution ranges. In addition to temperature and ocean acidification, increasing levels of hyposaline stress due to extreme precipitation events a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee30910039068430c0fe1d78e3e7cbce
https://pubmed.ncbi.nlm.nih.gov/22899524

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