Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Loredana Salerno"'
Autor:
Loredana Salerno, Antonietta Notaro, Valeria Consoli, Federica Affranchi, Valeria Pittalà, Valeria Sorrenti, Luca Vanella, Michela Giuliano, Sebastiano Intagliata
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractColon cancer remains a clinical challenge in industrialised countries. Its treatment with 5-Flurouracil (5-FU) develops many side effects and resistance. Thus, several strategies have been undertaken so far, including the use of drug cocktail
Externí odkaz:
https://doaj.org/article/7cbdfd4d092d43a08cfd45bb07e543c4
Autor:
Luca S. F. Nesic de Freitas, Cristiane França da Silva, Sebastiano Intagliata, Emanuele Amata, Loredana Salerno, Maria de Nazaré Correia Soeiro
Publikováno v:
Parasitology, Vol 150, Pp 359-364 (2023)
Chagas disease (CD) is a neglected tropical disease caused by the intracellular protozoan Trypanosoma cruzi that remains a serious public health issue affecting more than 6 million people worldwide. The available treatment includes 2 nitro derivative
Externí odkaz:
https://doaj.org/article/36e506d37a524e1ea8f1bad73e87793d
Autor:
Irene Suárez-Rojas, Montse Pérez-Fernández, Xue Bai, Ignacio Martínez-Martel, Sebastiano Intagliata, Valeria Pittalà, Loredana Salerno, Olga Pol
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1859 (2023)
Neuropathic pain is a type of pain that persists for a long time and becomes pathological. Additionally, the anxiodepressive disorders derived from neuropathic pain are difficult to palliate with the current treatments and need to be resolved. Then,
Externí odkaz:
https://doaj.org/article/cdabdd8d52d54e6885020d46168e7069
Autor:
Montse Pérez-Fernández, Irene Suárez-Rojas, Xue Bai, Ignacio Martínez-Martel, Valeria Ciaffaglione, Valeria Pittalà, Loredana Salerno, Olga Pol
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1794 (2023)
Chronic pain caused by persistent inflammation is current in multiple diseases and has a strong negative impact on society. It is commonly associated with several mental illnesses, which can exert a negative influence on pain perception, and needs to
Externí odkaz:
https://doaj.org/article/e923ddf6868742af94fdf487923caca3
Autor:
Loredana Salerno, Luca Vanella, Valeria Sorrenti, Valeria Consoli, Valeria Ciaffaglione, Antonino N. Fallica, Vittorio Canale, Paweł Zajdel, Rosario Pignatello, Sebastiano Intagliata
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1377-1385 (2021)
In this work, the first mutual prodrug of 5-fluorouracil and heme oxygenase1 inhibitor (5-FU/HO-1 hybrid) has been designed, synthesised, and evaluated for its in vitro chemical and enzymatic hydrolysis stability. Predicted in silico physicochemical
Externí odkaz:
https://doaj.org/article/d08b3debd1ad442da383fcfbf840908f
Autor:
Valeria Consoli, Valeria Sorrenti, Valeria Pittalà, Khaled Greish, Agata Grazia D’Amico, Giuseppe Romeo, Sebastiano Intagliata, Loredana Salerno, Luca Vanella
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5709 (2022)
The term ferroptosis refers to a peculiar type of programmed cell death (PCD) mainly characterized by extensive iron-dependent lipid peroxidation. Recently, ferroptosis has been suggested as a potential new strategy for the treatment of several cance
Externí odkaz:
https://doaj.org/article/380e1ee12213498c897ccf57b8c315de
Autor:
Valeria Ciaffaglione, Valeria Consoli, Sebastiano Intagliata, Agostino Marrazzo, Giuseppe Romeo, Valeria Pittalà, Khaled Greish, Luca Vanella, Giuseppe Floresta, Antonio Rescifina, Loredana Salerno, Valeria Sorrenti
Publikováno v:
Molecules, Vol 27, Iss 10, p 3220 (2022)
This paper reports on a novel series of tyrosine kinase inhibitors (TKIs) potentially useful for the treatment of chronic myeloid leukemia (CML). The newly designed and synthesized compounds are structurally related to nilotinib (NIL), a second-gener
Externí odkaz:
https://doaj.org/article/04d5594b9bda4cd4bfd90b74c5595aec
Autor:
Emanuele Amata, Agostino Marrazzo, Maria Dichiara, Maria N. Modica, Loredana Salerno, Orazio Prezzavento, Giovanni Nastasi, Antonio Rescifina, Giuseppe Romeo, Valeria PittalÃ
Publikováno v:
Data in Brief, Vol 15, Iss , Pp 281-299 (2017)
The data have been obtained from the Heme Oxygenase Database (HemeOxDB) and refined according to the 2D-QSAR requirements. These data provide information about a set of more than 380 Heme Oxygenase-1 (HO-1) inhibitors. The development of the 2D-QSAR
Externí odkaz:
https://doaj.org/article/866e9a69d942462180b8d0332c324c05
Autor:
Giuseppe Romeo, Valeria Ciaffaglione, Emanuele Amata, Maria Dichiara, Loredana Calabrese, Luca Vanella, Valeria Sorrenti, Salvo Grosso, Agata Grazia D’Amico, Velia D’Agata, Sebastiano Intagliata, Loredana Salerno
Publikováno v:
Molecules, Vol 26, Iss 13, p 3860 (2021)
Cancer is a multifactorial disease that may be tackled by targeting different signaling pathways. Heme oxygenase-1 (HO-1) and sigma receptors (σRs) are both overexpressed in different human cancers, including prostate and brain, contributing to the
Externí odkaz:
https://doaj.org/article/c7c17f4ae8db4615a7d882c9978e04ba
Autor:
Giovanni Giurdanella, Anna Longo, Loredana Salerno, Giuseppe Romeo, Sebastiano Intagliata, Gabriella Lupo, Alfio Distefano, Chiara Bianca Maria Platania, Claudio Bucolo, Giovanni Li Volti, Carmelina Daniela Anfuso, Valeria Pittalà
Publikováno v:
Antioxidants, Vol 10, Iss 6, p 831 (2021)
Glucose induces corneal epithelial dysfunctions characterized by delayed wound repair. Nuclear erythroid 2-related factor 2 (Nrf2) mediates cell protection mechanisms even through the Heme oxygenase-1 (HO-1) up-regulation. Here, we synthesized new HO
Externí odkaz:
https://doaj.org/article/304c6803054d48d79144dbafd13fcaca