Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Loredana Porcu"'
Autor:
Valeria Sogos, Maria Francesca Manchinu, Susanna Porcu, Loredana Porcu, Isadora Asunis, Daniela Poddie, Paolo Moi, Maria Franca Marongiu, Frank Grosveld, Maria Serafina Ristaldi, Maria Giuseppina Marini, Antonio Cao
Publikováno v:
Molecular and Cellular Biology, 31(19), 4144-4154. American Society for Microbiology
A key regulatory gene in definitive erythropoiesis is the erythroid Kruppel-like factor (Eklf or Klf1). Klf1 knockout (KO) mice die in utero due to severe anemia, while residual circulating red blood cells retain their nuclei. Dnase2a is another crit
Autor:
Paolo Moi, M. Giuseppina Loi, M. Giuseppina Marini, M. Serafina Ristaldi, Susanna Porcu, Antonio Cao, Loredana Porcu, Isadora Asunis, Tohru Ikuta
Publikováno v:
British Journal of Haematology. 149:748-758
KLF1/EKLF and related Krueppel-like factors (KLFs) are variably implicated in the regulation of the HBB-like globin genes. Prompted by the observation that four KLF sites are distributed in the human alpha-globin gene (HBA) promoter, we investigated
Autor:
Sonia Garritano, Paolo Moi, Stefano Landi, Maria Giuseppina Marini, Giuseppe Rainaldi, Loredana Porcu, Roberto Barale, Massimo Chiarugi, Laura Boldrini, Federica Gemignani, Gabriella Fontanini, Ilaria Bellini, Letizia Pitto
Publikováno v:
Human Mutation. 31:456-465
The transcription of the ΔN133p53 isoform of the TP53 gene is controlled by an internal promoter region (IPR) containing eight polymorphisms in 11 common haplotypes, following a resequencing of 47 Caucasians. We assayed the functional effects of the
Autor:
Loredana Porcu, Maria Giuseppina Loi, Maria Giuseppina Marini, Antonio Cao, Isadora Asunis, Arianna Brucchietti, Paolo Moi, Maria Giulia Salgo
Publikováno v:
British Journal of Haematology. 127:114-117
The transcription factor erythroid Kruppel-like factor (EKLF) specifically activates the beta-globin gene by interacting with the proximal beta-globin CACCC box, a known hot spot for thalassaemia mutations. This study investigated whether EKLF could
Autor:
Kaimin Chan, Jefferson Y. Chan, M. Giuseppina Marini, Paolo Moi, Isadora Asunis, Yuet Wai Kan, Loredana Porcu, Antonio Cao
Publikováno v:
Scopus-Elsevier
ABSTRACT The erythroid-specific enhancer within hypersensitivity site 2 (HS2) of the human β-globin locus control region is required for high level globin gene expression. We used an oligonucleotide of the NF-E2 tandem repeat, within HS2, as recogni
Autor:
L. Casula, Paolo Moi, Antonio Cao, Isadora Asunis, Antonella Meloni, M. G. Marini, Loredana Porcu
Publikováno v:
Journal of Endocrinological Investigation. 25:557-560
A 15-month-old boy with severe rickets, that by clinical analysis was diagnosed as affected by hereditary pseudovitamin D deficiency rickets (PDDR), was evaluated for mutations in the 25OHD3 1alpha-hydroxylase gene. Molecular analysis showed a double
Autor:
Loredana Porcu, Pietro L. Indovina, Elena Bravo, Annarica Calcabrini, Maria Teresa Santini, Stefania Meschini, Giuseppe Arancia, Perla Filippini, Gabriella Rainaldi, Andrea Motta, Rocco Romano
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1531:111-131
The high resolution proton nuclear magnetic resonance (1H-NMR) spectra of two different cell lines exhibiting multidrug resistance (MDR) as demonstrated by the expression of the well-known energy-driven, membrane-bound 170 kDa P-glycoprotein pump kno
Autor:
M Giuseppina, Marini, Loredana, Porcu, Isadora, Asunis, M Giuseppina, Loi, M Serafina, Ristaldi, Susanna, Porcu, Tohru, Ikuta, Antonio, Cao, Paolo, Moi
Publikováno v:
British journal of haematology. 149(5)
KLF1/EKLF and related Krueppel-like factors (KLFs) are variably implicated in the regulation of the HBB-like globin genes. Prompted by the observation that four KLF sites are distributed in the human alpha-globin gene (HBA) promoter, we investigated
The distal beta-globin CACCC box is required for maximal stimulation of the beta-globin gene by EKLF
Autor:
Maria Giuseppina, Marini, Isadora, Asunis, Loredana, Porcu, Maria Giulia, Salgo, Maria Giuseppina, Loi, Arianna, Brucchietti, Antonio, Cao, Paolo, Moi
Publikováno v:
British journal of haematology. 127(1)
The transcription factor erythroid Kruppel-like factor (EKLF) specifically activates the beta-globin gene by interacting with the proximal beta-globin CACCC box, a known hot spot for thalassaemia mutations. This study investigated whether EKLF could
Autor:
Susanna Porcu, Marco Bianchi, Giuseppina M. Marini, Lorenza Ronfani, Franca M. Marongiu, Maria Serafina Ristaldi, Anotonella Ronchi, Anna Maria Sau, Francesca Manchinu, Daniela Poddie, Antonio Cao, Loredana Porcu, Annalisa Cabriolu, Isadora Asunis, Paolo Moi
Publikováno v:
Blood. 118:2152-2152
Abstract 2152 Hypersensitive site 2 (HS2) of the locus control region (LCR) is required for the optimal regulation of the beta globin gene cluster. Screening a λgt11 cord blood cDNA library with the tandem NFE2 repeat of HS2 as recognition site prob