Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Loredana, Puca"'
Autor:
Varadha Balaji Venkadakrishnan, Adam G. Presser, Richa Singh, Matthew A. Booker, Nicole A. Traphagen, Kenny Weng, Nathaniel C. E. Voss, Navin R. Mahadevan, Kei Mizuno, Loredana Puca, Osasenaga Idahor, Sheng-Yu Ku, Martin K. Bakht, Ashir A. Borah, Zachary T. Herbert, Michael Y. Tolstorukov, David A. Barbie, David S. Rickman, Myles Brown, Himisha Beltran
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and emerging therapeutic target that is overexpressed in most castration-resistant prostate cancers and implicated as a driver of disease progression and resistance to hormona
Externí odkaz:
https://doaj.org/article/3a09fcc40a5640f5a97df040787fb9ed
Autor:
Meixia Che, Aashi Chaturvedi, Sarah A. Munro, Samuel P. Pitzen, Alex Ling, Weijie Zhang, Josh Mentzer, Sheng-Yu Ku, Loredana Puca, Yanyun Zhu, Andries M. Bergman, Tesa M. Severson, Colleen Forster, Yuzhen Liu, Jacob Hildebrand, Mark Daniel, Ting-You Wang, Luke A. Selth, Theresa Hickey, Amina Zoubeidi, Martin Gleave, Rohan Bareja, Andrea Sboner, Wayne Tilley, Jason S. Carroll, Winston Tan, Manish Kohli, Rendong Yang, Andrew C. Hsieh, Paari Murugan, Wilbert Zwart, Himisha Beltran, R. Stephanie Huang, Scott M. Dehm
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
While many treatments for prostate cancer suppress the androgen receptor it becomes reactivated during disease progression. Here, the authors show that a KLF5 transcriptional programme is also activated during treatment and promotes migration and the
Externí odkaz:
https://doaj.org/article/0d96a02002f9414c84ce1f8008d43a91
Autor:
Joanna Cyrta, Anke Augspach, Maria Rosaria De Filippo, Davide Prandi, Phillip Thienger, Matteo Benelli, Victoria Cooley, Rohan Bareja, David Wilkes, Sung-Suk Chae, Paola Cavaliere, Noah Dephoure, Anne-Christine Uldry, Sophie Braga Lagache, Luca Roma, Sandra Cohen, Muriel Jaquet, Laura P. Brandt, Mohammed Alshalalfa, Loredana Puca, Andrea Sboner, Felix Feng, Shangqian Wang, Himisha Beltran, Tamara Lotan, Martin Spahn, Marianna Kruithof-de Julio, Yu Chen, Karla V. Ballman, Francesca Demichelis, Salvatore Piscuoglio, Mark A. Rubin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The differentiation of prostate adenocarcinoma to neuroendocrine prostate cancer (CRPC-NE) is a mechanism of resistance to androgen deprivation therapy. Here the authors show that SWI/SNF chromatin-remodeling complex is deregulated in CRPC-NE and tha
Externí odkaz:
https://doaj.org/article/b36e0ab4d6324855a87fa9ba1ed5cc3e
Autor:
Haiyang Guo, Xinpei Ci, Musaddeque Ahmed, Junjie Tony Hua, Fraser Soares, Dong Lin, Loredana Puca, Aram Vosoughi, Hui Xue, Estelle Li, Peiran Su, Sujun Chen, Tran Nguyen, Yi Liang, Yuzhe Zhang, Xin Xu, Jing Xu, Anjali V. Sheahan, Wail Ba-Alawi, Si Zhang, Osman Mahamud, Ravi N. Vellanki, Martin Gleave, Robert G. Bristow, Benjamin Haibe-Kains, John T. Poirier, Charles M. Rudin, Ming-Sound Tsao, Bradly G. Wouters, Ladan Fazli, Felix Y. Feng, Leigh Ellis, Theo van der Kwast, Alejandro Berlin, Marianne Koritzinsky, Paul C. Boutros, Amina Zoubeidi, Himisha Beltran, Yuzhuo Wang, Housheng Hansen He
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Neuroendocrine prostate cancer (NEPC) is characterized by loss of androgen receptor (AR) signaling during neuroendocrine transdifferentiation, resulting in resistance to AR-targeted therapy. Here they report ONECUT2 to drive NEPC tumorigenesis via re
Externí odkaz:
https://doaj.org/article/15eb3a591377407ab3aae62e9aca95cb
Autor:
Loredana Puca, Michele S. Dowless, Carmen M. Perez-Ferreiro, Maria Jesus Ortiz-Ruiz, Gregory P. Donoho, Andrew Capen, Lysiane Huber, Sarah M. Bogner, Dongling Fei, Jason R. Manro, Chun Ping Yu, Wei Guo Xu, Rui Wang, Shuang Chen, Mark A. Hicks, Parisa Zolfaghari, Andrew Faber, Raymond Gilmour, Monica D. Ramstetter, Matthew T. Chang, Maria Jose Lallena, Xuequian Gong, David M. Hyman, Lillian M. Smyth, Barbara J. Brandhuber, Barry S. Taylor, Anke Klippel
Publikováno v:
Cancer Research. 83:P4-08
Background Phosphoinositide 3-kinase alpha (PI3Kα) H1047R mutations are activating oncogenic events that occur in ~15% of breast cancers (BC). Early generation PI3Kα inhibitors target both wild-type (WT) and mutant PI3Kα and, as a result, their ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::527fc9e133f9687e3e79e24c582b9519
https://doi.org/10.1158/1538-7445.sabcs22-p4-08-02
https://doi.org/10.1158/1538-7445.sabcs22-p4-08-02
Autor:
Loredana Puca, Rohan Bareja, Davide Prandi, Reid Shaw, Matteo Benelli, Wouter R. Karthaus, Judy Hess, Michael Sigouros, Adam Donoghue, Myriam Kossai, Dong Gao, Joanna Cyrta, Verena Sailer, Aram Vosoughi, Chantal Pauli, Yelena Churakova, Cynthia Cheung, Lesa Dayal Deonarine, Terra J. McNary, Rachele Rosati, Scott T. Tagawa, David M. Nanus, Juan Miguel Mosquera, Charles L. Sawyers, Yu Chen, Giorgio Inghirami, Rema A. Rao, Carla Grandori, Olivier Elemento, Andrea Sboner, Francesca Demichelis, Mark A. Rubin, Himisha Beltran
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
There are few available models to study neuroendocrine prostate cancer. Here they develop and characterize patient derived organoids from metastatic lesions, use these models to show the role of EZH2 in driving neuroendocrine phenotype, and perform h
Externí odkaz:
https://doaj.org/article/6298c3191ca44642a1ee5adc286008a4
Autor:
Mark A. Rubin, Lewis C. Cantley, Carla Grandori, Christopher J. Kemp, Francesca Demichelis, Himisha Beltran, Olivier Elemento, Brady Bernard, Vijayakrishna K. Gadi, Brooke E. Emerling, Bishoy M. Faltas, Brian Robinson, Juan Miguel Mosquera, Rema Rao, David Pisapia, Joanna Triscott, Cynthia Cheung, Yelena Churakova, Terra J. McNary, Rachele Rosati, Loredana Puca, Michael Augello, Verena Sailer, Andrea Sboner, Tarcisio Fedrizzi, Reid Shaw, Davide Prandi, Benjamin D. Hopkins, Chantal Pauli
Supplementary Table 3. Patient A single and duparlisib combination high throughout drug screen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378e6ba63e4a826c34c90cc2c202d976
https://doi.org/10.1158/2159-8290.22531865
https://doi.org/10.1158/2159-8290.22531865
Autor:
Mark A. Rubin, Lewis C. Cantley, Carla Grandori, Christopher J. Kemp, Francesca Demichelis, Himisha Beltran, Olivier Elemento, Brady Bernard, Vijayakrishna K. Gadi, Brooke E. Emerling, Bishoy M. Faltas, Brian Robinson, Juan Miguel Mosquera, Rema Rao, David Pisapia, Joanna Triscott, Cynthia Cheung, Yelena Churakova, Terra J. McNary, Rachele Rosati, Loredana Puca, Michael Augello, Verena Sailer, Andrea Sboner, Tarcisio Fedrizzi, Reid Shaw, Davide Prandi, Benjamin D. Hopkins, Chantal Pauli
Supplementary Table 5. Patient B Single and buparlisib Combination High Throughput Drug Screen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114e5e6528bcdf7c69d82fe41752773a
https://doi.org/10.1158/2159-8290.22531856
https://doi.org/10.1158/2159-8290.22531856
Autor:
Mark A. Rubin, Lewis C. Cantley, Carla Grandori, Christopher J. Kemp, Francesca Demichelis, Himisha Beltran, Olivier Elemento, Brady Bernard, Vijayakrishna K. Gadi, Brooke E. Emerling, Bishoy M. Faltas, Brian Robinson, Juan Miguel Mosquera, Rema Rao, David Pisapia, Joanna Triscott, Cynthia Cheung, Yelena Churakova, Terra J. McNary, Rachele Rosati, Loredana Puca, Michael Augello, Verena Sailer, Andrea Sboner, Tarcisio Fedrizzi, Reid Shaw, Davide Prandi, Benjamin D. Hopkins, Chantal Pauli
Supplementary Figures 1 - 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac1bebcc4ceb6fdefa1e71ac64f13ca
https://doi.org/10.1158/2159-8290.22531877.v1
https://doi.org/10.1158/2159-8290.22531877.v1
Autor:
Mark A. Rubin, Lewis C. Cantley, Carla Grandori, Christopher J. Kemp, Francesca Demichelis, Himisha Beltran, Olivier Elemento, Brady Bernard, Vijayakrishna K. Gadi, Brooke E. Emerling, Bishoy M. Faltas, Brian Robinson, Juan Miguel Mosquera, Rema Rao, David Pisapia, Joanna Triscott, Cynthia Cheung, Yelena Churakova, Terra J. McNary, Rachele Rosati, Loredana Puca, Michael Augello, Verena Sailer, Andrea Sboner, Tarcisio Fedrizzi, Reid Shaw, Davide Prandi, Benjamin D. Hopkins, Chantal Pauli
Supplementary Table 2. Drug Library Concentrations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3054b56827ed5e8ab3aba3d2b56c6a
https://doi.org/10.1158/2159-8290.22531871
https://doi.org/10.1158/2159-8290.22531871