Single-Cell Analysis of CX3CR1+ Cells Reveals a Pathogenic Role for BIRC5+ Myeloid Proliferating Cells Driven by Staphylococcus aureus Leukotoxins.

Autor: Loredan DG; Department of Microbiology, New York University Grossman School of Medicine, New York, NY.; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY., Devlin JC; Department of Microbiology, New York University Grossman School of Medicine, New York, NY., Lacey KA; Department of Microbiology, New York University Grossman School of Medicine, New York, NY., Howard N; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Chen Z; Department of Microbiology, New York University Grossman School of Medicine, New York, NY., Zwack EE; Department of Microbiology, New York University Grossman School of Medicine, New York, NY., Lin JD; Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei City, Taiwan.; Center for Computational and Systems Biology, National Taiwan University, Taipei City, Taiwan., Ruggles KV; Institute of Systems Genetics, New York University Grossman School of Medicine, New York, NY.; Division of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY., Khanna KM; Department of Microbiology, New York University Grossman School of Medicine, New York, NY.; Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY., Torres VJ; Department of Microbiology, New York University Grossman School of Medicine, New York, NY.; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY., Loke P; Department of Microbiology, New York University Grossman School of Medicine, New York, NY.; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2023 Sep 01; Vol. 211 (5), pp. 836-843.

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors.

Autor: Yamamoto K; Institute for Cancer Genetics, Columbia Unviersity, New York, United States.; Department of Pathology and Cell Biology, Columbia University, New York, United States.; College of Physicians and Surgeons, Columbia University, New York, United States.; Pathobiology and Molecular Medicine Graduate Program, Columbia University, New York, United States., Wang J; Department of Biomedical Informatics, Columbia University, New York, United States.; Department of Systems Biology, Columbia University, New York, United States.; College of Physicians & Surgeons, Columbia University, New York, United States., Sprinzen L; Institute for Cancer Genetics, Columbia Unviersity, New York, United States.; Department of Pathology and Cell Biology, Columbia University, New York, United States.; College of Physicians and Surgeons, Columbia University, New York, United States.; Pathobiology and Molecular Medicine Graduate Program, Columbia University, New York, United States., Xu J; Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, La Jolla, United States., Haddock CJ; Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, United States., Li C; Institute for Cancer Genetics, Columbia Unviersity, New York, United States.; Department of Pathology and Cell Biology, Columbia University, New York, United States.; College of Physicians and Surgeons, Columbia University, New York, United States., Lee BJ; Institute for Cancer Genetics, Columbia Unviersity, New York, United States.; Department of Pathology and Cell Biology, Columbia University, New York, United States.; College of Physicians and Surgeons, Columbia University, New York, United States., Loredan DG; Institute for Cancer Genetics, Columbia Unviersity, New York, United States.; Department of Pathology and Cell Biology, Columbia University, New York, United States.; College of Physicians and Surgeons, Columbia University, New York, United States., Jiang W; Institute for Cancer Genetics, Columbia Unviersity, New York, United States.; Department of Pathology and Cell Biology, Columbia University, New York, United States.; College of Physicians and Surgeons, Columbia University, New York, United States., Vindigni A; Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, United States., Wang D; Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, La Jolla, United States., Rabadan R; Department of Biomedical Informatics, Columbia University, New York, United States.; Department of Systems Biology, Columbia University, New York, United States.; College of Physicians & Surgeons, Columbia University, New York, United States., Zha S; Institute for Cancer Genetics, Columbia Unviersity, New York, United States.; Department of Pathology and Cell Biology, Columbia University, New York, United States.; College of Physicians and Surgeons, Columbia University, New York, United States.; Division of Pediatric Oncology, Hematology and Stem Cell Transplantation, Columbia University, New York, United States.; Department of Pediatrics, Columbia University, New York, United States.; College of Physicians & Surgeons, Columbia University, New York, United States.

Publikováno v: ELife [Elife] 2016 Jun 15; Vol. 5. Date of Electronic Publication: 2016 Jun 15.