Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lorea Valcarcel"'
Autor:
Cherif Badja, Sophie Momen, Gene Ching Chiek Koh, Soraya Boushaki, Theodoros I. Roumeliotis, Zuza Kozik, Ian Jones, Vicky Bousgouni, João M.L. Dias, Marios G. Krokidis, Jamie Young, Hongwei Chen, Ming Yang, France Docquier, Yasin Memari, Lorea Valcarcel-Zimenez, Komal Gupta, Li Ren Kong, Heather Fawcett, Florian Robert, Salome Zhao, Andrea Degasperi, Yogesh Kumar, Helen Davies, Rebecca Harris, Christian Frezza, Chryssostomos Chatgilialoglu, Robert Sarkany, Alan Lehmann, Chris Bakal, Jyoti Choudhary, Hiva Fassihi, Serena Nik-Zainal
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114243- (2024)
Summary: Xeroderma pigmentosum (XP) is caused by defective nucleotide excision repair of DNA damage. This results in hypersensitivity to ultraviolet light and increased skin cancer risk, as sunlight-induced photoproducts remain unrepaired. However, m
Externí odkaz:
https://doaj.org/article/3afcfcc423e04f808db8a71c2cb5d72f
Autor:
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S. H. Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R. Zecchini, Sabrina H. Rossi, Charlie Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent Gnanapragasam, Anne Y. Warren, Grant D. Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Primary and metastatic tumours have different metabolic phenotypes due to changes in nutrient availability. Here the authors perform multi-omic analyses of primary and metastatic renal cancer cells grown in a physiological medium and show that the re
Externí odkaz:
https://doaj.org/article/5e44e98a96b7403ead5d644996d99bb6
Autor:
Connor Rogerson, Marco Sciacovelli, Lucas A. Maddalena, Andromachi Pouikli, Marc Segarra-Mondejar, Lorea Valcarcel-Jimenez, Christina Schmidt, Ming Yang, Elena Ivanova, Joshua Kent, Ariane Mora, Danya Cheeseman, Jason S. Carroll, Gavin Kelsey, Christian Frezza
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112751- (2023)
Summary: Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a cancer syndrome caused by inactivating germline mutations in fumarate hydratase (FH) and subsequent accumulation of fumarate. Fumarate accumulation leads to profound epigenetic cha
Externí odkaz:
https://doaj.org/article/4a018807958940d294037e2083e5da34
Autor:
Laura Herrero, Lorea Valcarcel, Crhistiane Andressa da Silva, Nerea Albert, Antoni Diez-Noguera, Trinitat Cambras, Dolors Serra
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122570 (2015)
The circadian clock regulates metabolic homeostasis and its disruption predisposes to obesity and other metabolic diseases. However, the effect of phase shifts on metabolism is not completely understood. We examined whether alterations in the circadi
Externí odkaz:
https://doaj.org/article/490e9e121d454ec79fa6b7583212b101
Autor:
Cherif Badja, Sophie Momen, Gene Ching Cheik Koh, Soraya Boushaki, Theodoros I. Roumeliotis, Zuza Kozik, Ian Jones, Vicky Bousgouni, João M. L. Dias, Marios G. Krokidis, Jamie Young, Hongwei Chen, Ming Yang, France Docquier, Yasin Memari, Lorea Valcarcel-Jimenez, Komal Gupta, Li Ren Kong, Heather Fawcett, Florian Robert, Salome Zhao, Andrea Degasperi, Helen Davies, Rebecca Harris, Christian Frezza, Chryssostomos Chatgilialoglu, Robert Sarkany, Alan Lehmann, Chris Bakal, Jyoti Choudhary, Hiva Fassihi, Serena Nik-Zainal
Xeroderma pigmentosum (XP) is characterized by defective repair of ultraviolet radiation(UVR)-induced DNA damage. Patients have UVR hypersensitivity and increased skin cancer risk. Effective photoprotection has reduced childhood cancer-related deaths
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b233f67d5f67e6776714ccf87baf0001
https://doi.org/10.1101/2023.05.22.23290124
https://doi.org/10.1101/2023.05.22.23290124
Autor:
Erika Monelli, Pilar Villacampa, Amaia Zabala-Letona, Anabel Martinez-Romero, Judith Llena, Daniel Beiroa, Leonor Gouveia, Iñigo Chivite, Sebastián Zagmutt, Pau Gama-Perez, Oscar Osorio-Conles, Laia Muixi, Ainara Martinez-Gonzalez, Sandra D. Castillo, Natalia Martín-Martín, Pau Castel, Lorea Valcarcel-Jimenez, Irene Garcia-Gonzalez, Josep A. Villena, Sonia Fernandez-Ruiz, Dolors Serra, Laura Herrero, Rui Benedito, Pablo Garcia-Roves, Josep Vidal, Paul Cohen, Rubén Nogueiras, Marc Claret, Arkaitz Carracedo, Mariona Graupera
Publikováno v:
Nature Metabolism. 4:327-343
Reciprocal interactions between endothelial cells (ECs) and adipocytes are fundamental to maintain white adipose tissue (WAT) homeostasis, as illustrated by the activation of angiogenesis upon WAT expansion, a process that is impaired in obesity. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4a65755dc2993a750f18cb4aa2b0f4
https://doi.org/10.1038/s42255-022-00544-6
https://doi.org/10.1038/s42255-022-00544-6
Autor:
Lorea Valcarcel-Jimenez, Connor Rogerson, Cissy Yong, Christina Schmidt, Ming Yang, Monica Cremades-Rodelgo, Victoria Harle, Victoria Offord, Kim Wong, Ariane Mora, Alyson Speed, Veronica Caraffini, Maxine Gia Binh Tran, Eamonn R. Maher, Grant D. Stewart, Sakari Vanharanta, David J. Adams, Christian Frezza
Publikováno v:
Science Advances. 8
Fumarate hydratase (FH) is a mitochondrial enzyme that catalyzes the reversible hydration of fumarate to malate in the tricarboxylic acid (TCA) cycle. Germline mutations of FH lead to hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e25b92f275d4c9db74028e103d2d9b90
https://doi.org/10.1126/sciadv.abq8297
https://doi.org/10.1126/sciadv.abq8297
Akademický článek
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Autor:
Connor Rogerson, Marco Sciacovelli, Lucas A Maddalena, Lorea Valcarcel-Jimenez, Christina Schmidt, Ming Yang, Elena Ivanova, Joshua Kent, Ariane Mora, Danya Cheeseman, Jason S Carroll, Gavin Kelsey, Christian Frezza
Hereditary Leiomyomatosis and renal cell cancer (HLRCC) is a cancer syndrome caused by inactivating germline mutations in fumarate hydratase (FH) and subsequent accumulation of fumarate. Fumarate accumulation leads to the activation of an anti-oxidan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d597dfc3cdcb4747096b4dc97bc774c6
https://doi.org/10.1101/2022.07.04.498412
https://doi.org/10.1101/2022.07.04.498412
Publikováno v:
Nature Reviews Molecular Cell Biology. 22:22-38
Mechanical forces shape cells and tissues during development and adult homeostasis. In addition, they also signal to cells via mechanotransduction pathways to control cell proliferation, differentiation and death. These processes require metabolism o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877f19294ffa32a2f1cf85145842d949
https://doi.org/10.1038/s41580-020-00306-w
https://doi.org/10.1038/s41580-020-00306-w