Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Lorea Alejaldre"'
1
Akademický článek
Known Evolutionary Paths Are Accessible to Engineered ß-Lactamases Having Altered Protein Motions at the Timescale of Catalytic Turnover
Autor: Lorea Alejaldre, Claudèle Lemay-St-Denis, Carles Perez Lopez, Ferran Sancho Jodar, Victor Guallar, Joelle N. Pelletier
Publikováno v: Frontiers in Molecular Biosciences, Vol 7 (2020)
The evolution of new protein functions is dependent upon inherent biophysical features of proteins. Whereas, it has been shown that changes in protein dynamics can occur in the course of directed molecular evolution trajectories and contribute to new
Externí odkaz: https://doaj.org/article/11b0ecc1cbe3405f8836687623476c62
Zobrazit plný text záznamu
2
Akademický článek
Holistic engineering of Cal-A lipase chain-length selectivity identifies triglyceride binding hot-spot.
Autor: Daniela Quaglia, Lorea Alejaldre, Sara Ouadhi, Olivier Rousseau, Joelle N Pelletier
Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0210100 (2019)
Through the application of a region-focused saturation mutagenesis and randomization approach, protein engineering of the Cal-A enzyme was undertaken with the goal of conferring new triglyceride selectivity. Little is known about the mode of triglyce
Externí odkaz: https://doaj.org/article/914f45d074ee4c0ca8535fb250c30289
Zobrazit plný text záznamu
4
A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype
Autor: Claudèle Lemay-St-Denis, Lorea Alejaldre, Zakaria Jemouai, Kiana Lafontaine, Maxime St-Aubin, Katia Hitache, Donya Valikhani, Nuwani W. Weerasinghe, Myriam Létourneau, Christopher J. Thibodeaux, Nicolas Doucet, Christian Baron, Janine N. Copp, Joelle N. Pelletier
Publikováno v: Philosophical Transactions of the Royal Society B: Biological Sciences. 378
We present a potential mechanism for emergence of catalytic activity that is essential for survival, from a non-catalytic protein fold. The type B dihydrofolate reductase (DfrB) family of enzymes were first identified in pathogenic bacteria because t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e4eea807c3f710be1ab55aacf4e9604
https://doi.org/10.1098/rstb.2022.0040
Zobrazit plný text záznamu
5
SEVA 4.0: an update of the Standard European Vector Architecture database for advanced analysis and programming of bacterial phenotypes
Autor: Esteban Martínez-García, Sofía Fraile, Elena Algar, Tomás Aparicio, Elena Velázquez, Belén Calles, Huseyin Tas, Blas Blázquez, Bruno Martín, Clara Prieto, Lucas Sánchez-Sampedro, Morten H H Nørholm, Daniel C Volke, Nicolas T Wirth, Pavel Dvořák, Lorea Alejaldre, Lewis Grozinger, Matthew Crowther, Angel Goñi-Moreno, Pablo I Nikel, Juan Nogales, Víctor de Lorenzo
Publikováno v: Martínez-García, E, Fraile, S, Algar, E, Aparicio, T, Velázquez, E, Calles, B, Tas, H, Blázquez, B, Martín, B, Prieto, C, Sánchez-Sampedro, L, Nørholm, M H H, Volke, D C, Wirth, N T, Dvořák, P, Alejaldre, L, Grozinger, L, Crowther, M, Goñi-Moreno, A, Nikel, P I, Nogales, J & de Lorenzo, V 2023, ' SEVA 4.0: an update of the Standard European Vector Architecture database for advanced analysis and programming of bacterial phenotypes ', Nucleic Acids Research, vol. 51, no. D1, pp. D1558–D1567 . https://doi.org/10.1093/nar/gkac1059
The SEVA platform (https://seva-plasmids.com) was launched one decade ago, both as a database (DB) and as a physical repository of plasmid vectors for genetic analysis and engineering of Gram-negative bacteria with a structure and nomenclature that f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f1b039e447131b2ad3fae697ca1df4
https://orbit.dtu.dk/en/publications/4e321df4-ea29-4104-8b3f-a08b9154a3a8
Zobrazit plný text záznamu
6
Methods for enzyme library creation: Which one will you choose?: A guide for novices and experts to introduce genetic diversity
Autor: Lorea Alejaldre, Daniela Quaglia, Joelle N. Pelletier
Publikováno v: BioEssays : news and reviews in molecular, cellular and developmental biologyREFERENCES. 43(8)
Enzyme engineering allows to explore sequence diversity in search for new properties. The scientific literature is populated with methods to create enzyme libraries for engineering purposes, however, choosing a suitable method for the creation of mut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc09db2f0f75f26e5fd8eaac771fd9f
https://pubmed.ncbi.nlm.nih.gov/34263468
Zobrazit plný text záznamu
7
Holistic engineering of Cal-A lipase chain-length selectivity identifies triglyceride binding hot-spot
Autor: Olivier Rousseau, Joelle N. Pelletier, Sara Ouadhi, Daniela Quaglia, Lorea Alejaldre
Publikováno v: PLoS ONE
PLoS ONE, Vol 14, Iss 1, p e0210100 (2019)
Through the application of a region-focused saturation mutagenesis and randomization approach, protein engineering of the Cal-A enzyme was undertaken with the goal of conferring new triglyceride selectivity. Little is known about the mode of triglyce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a7890ced336dabd86a54a766cce927
Zobrazit plný text záznamu
8
Development of sulfahydantoin derivatives as β-lactamase inhibitors
Autor: Laurie Bédard, Lorea Alejaldre, Joelle N. Pelletier, Camille Lapointe Verreault, Charles-Olivier Normandeau, Claudèle Lemay-St-Denis, Rosalie Lamoureux, Sophie M. C. Gobeil, Normand Voyer, Pierre-Alexandre Paquet-Côté
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 35:127781
Sulfahydantoin-based molecules may provide a means to counteract antibiotic resistance, which is on the rise. These molecules may act as inhibitors of β-lactamase enzymes, which are key in some resistance mechanisms. In this paper, we report on the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3295419f962f244598d7cd5b32d96963
https://doi.org/10.1016/j.bmcl.2021.127781
Zobrazit plný text záznamu
9
G-Equivalent Acceleration Tolerance in the Eutardigrade Species Hypsibius dujardini
Autor: Lorea Alejaldre, Tarushika Vasanthan, J. R. Stone, Jessica Hider, Nabiha Husain, Shreya Patel, Bavithra Umapathisivam
Publikováno v: Astrobiology. 17(1)
Tardigrades are microscopic organisms renowned for their ability to survive extreme environmental conditions. Tardigrade extreme-tolerance research has centered on the ability to withstand desiccation, low and high temperatures, and high hydrostatic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e6399628da8f81d6c5fb99ec1a0067
https://pubmed.ncbi.nlm.nih.gov/28051326
Zobrazit plný text záznamu
10
Integron-Associated DfrB4, a Previously Uncharacterized Member of the Trimethoprim-Resistant Dihydrofolate Reductase B Family, Is a Clinically Identified Emergent Source of Antibiotic Resistance
Autor: Joelle N. Pelletier, Thaddeus J. Edens, Lorea Alejaldre, Amee R. Manges, Jacynthe L. Toulouse
Publikováno v: Antimicrobial agents and chemotherapy. 61(5)
Whole-genome sequencing of trimethoprim-resistant Escherichia coli clinical isolates identified a member of the trimethoprim-resistant type II dihydrofolate reductase gene family ( dfrB ). The dfrB4 gene was located within a class I integron flanked
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8e4536c204bf800f0aa7ad6ce167fb
https://pubmed.ncbi.nlm.nih.gov/28242670
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje