Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Lord, CJ"'
Autor:
Lüscher, Bernhard, Ahel, I, Altmeyer, Matthias, Ashworth, Alan, Bai, Peter, Chang, Paul, Cohen, Michael S., Corda, Daniela, Dantzer, F., Daugherty, MD, Dawson, TM, Dawson, VL, Deindl, S, Fehr, AR, Feijs, KLH, Filippov, DV, Gagné, JP, Grimaldi, Giulia, Guettler, S, Hoch, NC, Hottiger, MO, Korn, P, Kraus, WL, Ladurner, Andreas G., Lehtiö, Lari, Leung, AKL, Lord, CJ, Mangerich, A, Matic, Ivan, Matthews, Jason, Moldovan, George-Lucian, Moss, Joel, Natoli, Gioacchino, Nielsen, Michael L., Niepel, Mario, Nolte, Friedrich, Pascal, John, Paschal, Bryce M, Pawłowski, Krzysztof, Poirier, Guy G, Smith, Susan, Timinszky, Gyula, Wang, Zhao-Qi, Yélamos, José, Xiaochun, Yu, Zaja, Roko, Ziegler, Mathias
Publikováno v:
Lüscher, Bernhard Ahel, I Altmeyer, Matthias Ashworth, Alan Bai, Peter Chang, Paul Cohen, Michael S. Corda, Daniela Dantzer, F. Daugherty, MD Dawson, TM Dawson, VL Deindl, S Fehr, AR Feijs, KLH Filippov, DV Gagné, JP Grimaldi, Giulia Guettler, S Hoch, NC Hottiger, MO Korn, P Kraus, WL Lad
The FEBS Jo
The FEBS Jo
Autor:
Miller, RE, Leary, A, Scott, CL, Serra, V, Lord, CJ, Bowtell, D, Chang, DK, Garsed, DW, Jonkers, J, Ledermann, JA, Nik-Zainal, S, Ray-Coquard, I, Shah, SP, Matias-Guiu, X, Swisher, EM, Yates, LR
BACKGROUND: Homologous recombination repair deficiency (HRD) is a frequent feature of high-grade serous ovarian, fallopian tube and peritoneal carcinoma (HGSC) and is associated with sensitivity to PARP inhibitor (PARPi) therapy. HRD testing provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3a487d7dc9c28d291eaf3a50a39ad3
Autor:
Maguire, SL, Peck, B, Wai, PT, Campbell, J, Barker, H, Gulati, A, Daley, F, Vyse, S, Huang, P, Lord, CJ, Farnie, G, Brennan, K, Natrajan, R
Publikováno v:
Maguire, S L, Peck, B, Wai, P T, Campbell, J, Barker, H, Gulati, A, Daley, F, Vyse, S, Huang, P, Lord, C J, Farnie, G, Brennan, K & Natrajan, R 2016, ' Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model ', Journal of Pathology, vol. 240, no. 3, pp. 315-328 . https://doi.org/10.1002/path.4778
The Journal of Pathology
The Journal of Pathology
The initiation and progression of breast cancer from the transformation of the normal epithelium to ductal carcinoma in situ (DCIS) and invasive disease is a complex process involving the acquisition of genetic alterations and changes in gene express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5821b0895a913f53df3cec7924292b1d
https://doi.org/10.1002/path.4778
https://doi.org/10.1002/path.4778
Autor:
Ashworth, Alan, Conti, A, Majorini, MT, Elliott, R, Lord, CJ, Cancelliere, C, Bardelli, A, Seneci, P, Walczak, H, Delia, D
Publikováno v:
Ashworth, Alan; Conti, A; Majorini, MT; Elliott, R; Lord, CJ; Cancelliere, C; et al.(2015). Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0sb1b1mw
KRAS is mutated in about 20-25% of all human cancers and especially in pancreatic, lung and colorectal tumors. Oncogenic KRAS stimulates several pro-survival pathways, but it also triggers the trans-activation of pro-apoptotic genes. In our work, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::9ec06f0ec9b8b4f7459a6139fcd8b576
http://www.escholarship.org/uc/item/0sb1b1mw
http://www.escholarship.org/uc/item/0sb1b1mw
Publikováno v:
Ashworth, Alan; Rajan, N; Elliott, RJR; Smith, A; Sinclair, N; Swift, S; et al.(2014). The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/07k1d7sz
CYLD, an ubiquitin hydrolase, has an expanding repertoire of regulatory roles in cell signalling and is dysregulated in a number of cancers. To dissect CYLD function we used a proteomics approach to identify CYLD interacting proteins and identified M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::d04c83ff22c8b1510ed11d063acb9082
http://www.escholarship.org/uc/item/07k1d7sz
http://www.escholarship.org/uc/item/07k1d7sz
Autor:
Ashworth, Alan, Orr, N, Lemnrau, A, Cooke, R, Fletcher, O, Tomczyk, K, Jones, M, Johnson, N, Lord, CJ, Mitsopoulos, C, Zvelebil, M
Publikováno v:
Ashworth, Alan; Orr, N; Lemnrau, A; Cooke, R; Fletcher, O; Tomczyk, K; et al.(2012). Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6jg486rg
We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::8253a99145ad7bf1f817b985245bd600
http://www.escholarship.org/uc/item/6jg486rg
http://www.escholarship.org/uc/item/6jg486rg
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