Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Lorcan McGarvey"'
Autor:
Aung Aung Kywe Moe, Nabita Singh, Matthew Dimmock, Katherine Cox, Lorcan McGarvey, Kian Fan Chung, Alice E. McGovern, Marcus McMahon, Amanda L. Richards, Michael J. Farrell, Stuart B. Mazzone
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104976- (2024)
Summary: Background: Chronic cough is a prevalent and difficult to treat condition often accompanied by cough hypersensitivity, characterised by cough triggered from exposure to low level sensory stimuli. The mechanisms underlying cough hypersensitiv
Externí odkaz:
https://doaj.org/article/a6a911536d944da982fcd2ec5a60ae8c
Autor:
Christian Friedrich, Klaus Francke, Surinder S. Birring, Jan Willem K. van den Berg, Paul A. Marsden, Lorcan McGarvey, Alice M. Turner, Pascal Wielders, Isabella Gashaw, Stefan Klein, Alyn H. Morice
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background P2X3 receptor antagonists seem to have a promising potential for treating patients with refractory chronic cough. In this double-blind, randomized, placebo-controlled study, we investigated the efficacy, safety, and tolerability o
Externí odkaz:
https://doaj.org/article/8316aafcc402495f86dbad236cbd0a17
Autor:
Lorcan McGarvey, Alyn H. Morice, Ashley Martin, Vicky W. Li, Michael J. Doane, Eduardo Urdaneta, Jonathan Schelfhout, Helen Ding, Eileen Fonseca
Publikováno v:
ERJ Open Research, Vol 9, Iss 4 (2023)
Background Chronic cough, defined as daily cough for at least 8 weeks, negatively affects quality of life and work productivity and increases healthcare resource utilisation. We aimed to determine the prevalence and burden of chronic cough in the UK.
Externí odkaz:
https://doaj.org/article/fac920275fc44d278d6bc90a4cbcfd6a
Autor:
Niamh Kelly, Lewis Winning, Christopher Irwin, Fionnuala T. Lundy, Dermot Linden, Lorcan McGarvey, Gerard J. Linden, Ikhlas A. El Karim
Publikováno v:
BMC Oral Health, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background A growing body of evidence suggests a role for oral bacteria in lung infections. This systematic review aimed to analyse the association between poor periodontal status and the frequency of chronic obstructive pulmonary disease (C
Externí odkaz:
https://doaj.org/article/17d1c635eaf1498c9b2901017adfeeed
Autor:
Elena Kum, Gordon H. Guyatt, Caroline Munoz, Suzanne Beaudin, Shelly-Anne Li, Rayid Abdulqawi, Huda Badri, Louis-Philippe Boulet, Ruchong Chen, Peter Dicpinigaitis, Lieven Dupont, Stephen K. Field, Cynthia L. French, Peter G. Gibson, Richard S. Irwin, Paul Marsden, Lorcan McGarvey, Jaclyn A. Smith, Woo-Jung Song, Paul M. O'Byrne, Imran Satia
Publikováno v:
ERJ Open Research, Vol 8, Iss 1 (2022)
Background Cough symptom severity represents an important subjective end-point to assess the impact of therapies for patients with refractory or unexplained chronic cough (RCC/UCC). As existing instruments assessing the severity of cough are neither
Externí odkaz:
https://doaj.org/article/151080ea31be480ea6c85ee1880825c7
Publikováno v:
European Respiratory Review, Vol 30, Iss 162 (2021)
Chronic cough is defined in adults as a cough that lasts for ≥8 weeks. When it proves intractable to standard-of-care treatment, it can be referred to as refractory chronic cough (RCC). Chronic cough is now understood to be a condition of neural dy
Externí odkaz:
https://doaj.org/article/c4a1e2e2a26740839b31eabe28c33b86
Publikováno v:
The Korean Journal of Internal Medicine, Vol 35, Iss 4, Pp 811-822 (2020)
Chronic cough is a common clinical condition with significant impact on quality of life and for which effective therapy remains an unmet clinical need. Over the past decade, there has been a major shift in how we approach this problem, driven by bett
Externí odkaz:
https://doaj.org/article/d0681749b06446adb9a3996907847236
Autor:
Valerie J. Ludbrook, Kate E. Hanrott, James L. Kreindler, Joanna E. Marks-Konczalik, Nick P. Bird, Debbie A. Hewens, Misba Beerahee, David J. Behm, Alyn Morice, Lorcan McGarvey, Sean M. Parker, Surinder S. Birring, Jaclyn Smith
Publikováno v:
ERJ Open Research, Vol 7, Iss 3 (2021)
Objective Airway sensory nerves involved in the cough reflex are activated by adenosine triphosphate (ATP) agonism of P2X purinoceptor 3 (P2X3) receptors. Transient receptor potential vanilloid 4 (TRPV4) channel activation causes ATP release from air
Externí odkaz:
https://doaj.org/article/8898a21c0e9847d39d530aa3f6cd63d4
Autor:
Tom Wilkinson, Rupert Dixon, Clive Page, Miles Carroll, Gareth Griffiths, Ling-Pei Ho, Anthony De Soyza, Timothy Felton, Keir E. Lewis, Karen Phekoo, James D. Chalmers, Anthony Gordon, Lorcan McGarvey, Jillian Doherty, Robert C. Read, Manu Shankar-Hari, Nuria Martinez-Alier, Michael O’Kelly, Graeme Duncan, Roelize Walles, James Sykes, Charlotte Summers, Dave Singh, on behalf of the ACCORD Collaborators
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-3 (2020)
Abstract Objectives Stage 1: To evaluate the safety and efficacy of candidate agents as add-on therapies to standard of care (SoC) in patients hospitalised with COVID-19 in a screening stage. Stage 2: To confirm the efficacy of candidate agents selec
Externí odkaz:
https://doaj.org/article/5114ae111ea449619c6befb8c55b775b
Autor:
David R. Muccino, Alyn H. Morice, Surinder S. Birring, Peter V. Dicpinigaitis, Ian D. Pavord, Christopher Assaid, Huub Jan Kleijn, Azher Hussain, Carmen La Rosa, Lorcan McGarvey, Jaclyn A. Smith
Publikováno v:
ERJ Open Research, Vol 6, Iss 4 (2020)
Background We present study designs, dose selection and preliminary patient characteristics from two phase 3 clinical trials of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough (RCC) or unexplained chronic cough (UCC). Methods COUG
Externí odkaz:
https://doaj.org/article/797aecd766a64455a4cd9c812cd2c339