Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Loran M. Killar"'
Autor:
Jerauld S. Skotnicki, George Theodore Grosu, Baihua Hu, Arie Zask, Loran M. Killar, John F. DiJoseph, Rebecca Cowling, Jamie Marie Davis, John W. Ellingboe, Thomas Walter, G. Jin, Venkatesan Aranapakam, Jannie Lea Baker, Amy Sung, Michele A. Sharr
Publikováno v:
Journal of Medicinal Chemistry. 46:2361-2375
The matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases that play a key role in both physiological and pathological tissue degradation. These enzymes are strictly regulated by endogenous inhibitors such as tissue inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8cc80b26df5698fa9a71866781f4a0b
https://doi.org/10.1021/jm0205548
https://doi.org/10.1021/jm0205548
Autor:
Rebecca Cowling, Michele A. Sharr, Jerauld S. Skotnicki, Zhang Bao Xu, Venkatesan Aranapakam, Vincent Sandanayaka, G. Jin, Arie Zask, Mila Du, John W. Ellingboe, Joseph Mcdevitt, Jannie Lea Baker, Jeff Tillett, Loran M. Killar, Jamie Marie Davis, Thomas Walter, Weiguang Zhao, Amy Sung, George Theodore Grosu, John F. DiJoseph, Levin Jeremy Ian
Publikováno v:
Journal of Medicinal Chemistry. 46:2376-2396
The matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases that play a key role in both physiological and pathological tissue degradation. In our preceding paper, we have reported on a series of novel and orally active N-hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93592dc8a1e6940279319e17ff2512ee
https://doi.org/10.1021/jm0205550
https://doi.org/10.1021/jm0205550
Autor:
Frances C. Nelson, Pranab K. Chanda, Gu Yansong, Michele A. Sharr, John F. DiJoseph, Jerauld S. Skotnicki, Jeremy I. Levin, Rebecca Cowling, Arie Zask, Chu-Lai Hsiao, Scott Cosmi, Amy Sung, Wade Edris, Loran M. Killar, James M. Wilhelm, Guixian Jin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:239-242
Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324268ed9ef83042163a444908494a13
https://doi.org/10.1016/s0960-894x(00)00644-2
https://doi.org/10.1016/s0960-894x(00)00644-2
Malonyl α-mercaptoketones and α-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors
Autor:
David A. Harris, Loran M. Killar, Michele A. Sharr, Xiao-Yi Xiao, David Tien, Lihong Shi, Dinesh V. Patel, David Alan Campbell, Jeremy I. Levin, Jerauld S. Skotnicki, Reza Mortezaei, John F. DiJoseph, Marc Navre, Satoru Ida, Yongwen Wang, Christina Louise Leone, Khehyong Ngu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:1157-1162
A novel series of matrix metalloproteinase (MMP) inhibitors is described. Incorporation of a terminal α-mercaptoketone or α-mercaptoalcohol in the zinc binding domain of a series of inhibitors led to compounds exhibiting low nanomolar activity agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e3528b6bdecc46eb4f7e36643461f5
https://doi.org/10.1016/s0960-894x(98)00185-1
https://doi.org/10.1016/s0960-894x(98)00185-1
Autor:
Dinesh V. Patel, Xiao-Yi Xiao, Lihong Shi, Marc Navre, David Campbell, Jerauld S. Skotnicki, Loran M. Killar, Michele A. Sharr, John F. DiJoseph, Jeremy I. Levin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:1163-1168
A series of succinyl based mercaptoketones and diastereomeric mercaptoalcohols were prepared and evaluated in vitro as inhibitors of the matrix metalloproteinases collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8f0f715e4ebab22a111a2e9f128a73
https://doi.org/10.1016/s0960-894x(98)00186-3
https://doi.org/10.1016/s0960-894x(98)00186-3
Autor:
Pranab K. Chanda, Franklin J. Moy, Mei Li Sung, Loran M. Killar, Robert Powers, Michael R. Pisano, Charlotte Urbano
Publikováno v:
Journal of Biomolecular NMR. 10:9-19
Fibroblast collagenase (MMP-1), a 169-residue protein with amolecular mass of 18.7 kDa, is a matrix metalloproteinase which has beenassociated with pathologies such as arthritis and cancer. The assignments ofthe 1H, 15N, 13CO and13C resonances, deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89eea26074a66760c0ab456490f6784b
https://doi.org/10.1023/a:1018362914316
https://doi.org/10.1023/a:1018362914316
Publikováno v:
Current Pharmaceutical Design. 2:624-661
Matrix metalloproteinases (MMP) have been implicated in a variety of diseases in which the destruction of connective tissue is an important pathological event. These include osteo and rheumatoid arthritis, tumor metastasis and angiogenesis, and corne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75b6207a4827cd22e324aca76a51c37b
https://doi.org/10.2174/1381612802666221004190555
https://doi.org/10.2174/1381612802666221004190555
Autor:
Laszlo L. Musza, Colin J. Barrow, Loran M. Killar, Raymond Cooper, Phyllis Speight, Amanda M. Gillum
Publikováno v:
Phytochemistry. 39:621-624
Three minor limonoid components, rubralins A-C, were isolated from the root of Trichilia rubra, whose structures were determined by extensive spectroscopic studies. They showed moderate inhibitory activity in a β 2 -integrin mediated cell adhesion a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f41cdbacd5515663ac4823ec7c9526a7
https://doi.org/10.1016/0031-9422(94)00959-w
https://doi.org/10.1016/0031-9422(94)00959-w
Autor:
Raymond Cooper, Phyllis Speight, Colin J. Barrow, Amanda M. Gillum, Susan McElhiney, Loran M. Killar, Laszlo L. Musza
Publikováno v:
Tetrahedron. 50:11369-11378
A series of seco-limonoids, with uncommon hemi ortho ester A-rings, was isolated from the root of Trichilia rubra. Their structures were determined by extensive spectroscopic studies. The five new and two previously known compounds were all found to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56e38235af5b391a8034ac7a944e2a58
https://doi.org/10.1016/s0040-4020(01)89279-6
https://doi.org/10.1016/s0040-4020(01)89279-6
Autor:
Colin J. Barrow, Loran M. Killar, Phyllis Speight, Amanda M. Gillum, Susan McElhiney, Raymond Cooper, Laszlo L. Musza
Publikováno v:
ChemInform. 26
A series of seco-limonoids, with uncommon hemi ortho ester A-rings, was isolated from the root of Trichilia rubra. Their structures were determined by extensive spectroscopic studies. The five new and two previously known compounds were all found to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::663194b0c0757cba1979bcda96a10c6d
https://doi.org/10.1002/chin.199511229
https://doi.org/10.1002/chin.199511229