Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Lora K. Heisler"'
Autor:
Eleanor J. McKay, Ineke Luijten, Xiong Weng, Pablo B. Martinez de Morentin, Elvira De Frutos González, Zhanguo Gao, Mikhail G. Kolonin, Lora K. Heisler, Robert K. Semple
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101933- (2024)
Objective: Alström Syndrome (AS), caused by biallelic ALMS1 mutations, includes obesity with disproportionately severe insulin resistant diabetes, dyslipidemia, and fatty liver. Prior studies suggest that hyperphagia is accounted for by loss of ALMS
Externí odkaz:
https://doaj.org/article/6169fc3899214b92ba7975f834effd36
Autor:
Ahlima Roumane, George D. Mcilroy, Nadine Sommer, Weiping Han, Lora K. Heisler, Justin J. Rochford
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
AimsIndividuals with lipodystrophies typically suffer from metabolic disease linked to adipose tissue dysfunction including lipoatrophic diabetes. In the most severe forms of lipodystrophy, congenital generalised lipodystrophy, adipose tissue may be
Externí odkaz:
https://doaj.org/article/20b3375b0bc4440c9aaa48799bfe0502
Autor:
Arimantas Lionikas, Ana I. Hernandez Cordero, Audrius Kilikevicius, Andrew M. Carroll, Guy S. Bewick, Lutz Bunger, Aivaras Ratkevicius, Lora K. Heisler, Mette Harboe, Claus Oxvig
Publikováno v:
Physiological Reports, Vol 11, Iss 15, Pp n/a-n/a (2023)
Abstract Aims Stanniocalcin‐2 (STC2) has recently been implicated in human muscle mass variability by genetic analysis. Biochemically, STC2 inhibits the proteolytic activity of the metalloproteinase PAPP‐A, which promotes muscle growth by upregul
Externí odkaz:
https://doaj.org/article/e1ba6f02377348389e9a1a242859a575
Autor:
Stefan Wagner, Daniel I. Brierley, Alasdair Leeson-Payne, Wanqing Jiang, Raffaella Chianese, Brian Y.H. Lam, Georgina K.C. Dowsett, Claudia Cristiano, David Lyons, Frank Reimann, Fiona M. Gribble, Pablo B. Martinez de Morentin, Giles S.H. Yeo, Stefan Trapp, Lora K. Heisler
Publikováno v:
Molecular Metabolism, Vol 68, Iss , Pp 101665- (2023)
Objective: Overweight and obesity are endemic in developed countries, with a substantial negative impact on human health. Medications developed to treat obesity include agonists for the G-protein coupled receptors glucagon-like peptide-1 (GLP-1R; e.g
Externí odkaz:
https://doaj.org/article/a7f4d6b4357e4a4d9af68e183e845a6f
Autor:
Ali J. Chakera, Paul S. Hurst, Gill Spyer, Emmanuel O. Ogunnowo-Bada, William J. Marsh, Christine H. Riches, Chen-Yu Yueh, S. Pauliina Markkula, Jeffrey W. Dalley, Roger D. Cox, Ian A. Macdonald, Stephanie A. Amiel, Kenneth M. MacLeod, Lora K. Heisler, Andrew T. Hattersley, Mark L. Evans
Publikováno v:
Molecular Metabolism, Vol 17, Iss , Pp 17-27 (2018)
Objective: Appropriate glucose levels are essential for survival; thus, the detection and correction of low blood glucose is of paramount importance. Hypoglycemia prompts an integrated response involving reduction in insulin release and secretion of
Externí odkaz:
https://doaj.org/article/5aa2ee6354054a39a0a0b99baae7f83c
Autor:
Alan C. Rupp, Margaret B. Allison, Justin C. Jones, Christa M. Patterson, Chelsea L. Faber, Nadejda Bozadjieva, Lora K. Heisler, Randy J. Seeley, David P. Olson, Martin G. Myers, Jr.
Publikováno v:
Molecular Metabolism, Vol 14, Iss , Pp 130-138 (2018)
Objective: To date, early developmental ablation of leptin receptor (LepRb) expression from circumscribed populations of hypothalamic neurons (e.g., arcuate nucleus (ARC) Pomc- or Agrp-expressing cells) has only minimally affected energy balance. In
Externí odkaz:
https://doaj.org/article/c98d701724a746e98f6e1b6ad33a19ac
Autor:
Luke K. Burke, Emmanuel Ogunnowo-Bada, Teodora Georgescu, Claudia Cristiano, Pablo B. Martinez de Morentin, Lourdes Valencia Torres, Giuseppe D'Agostino, Christine Riches, Nicholas Heeley, Yue Ruan, Marcelo Rubinstein, Malcolm J. Low, Martin G. Myers, Justin J. Rochford, Mark L. Evans, Lora K. Heisler
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1092-1102 (2017)
Objective: The increasing prevalence of type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the mechanisms mediating glucose homeostasis to accelerate the identification of new medicat
Externí odkaz:
https://doaj.org/article/d5d57fc4ef3a41a08e876808e1d9eeec
Autor:
Malgorzata S. Martin-Gronert, Claire J. Stocker, Edward T. Wargent, Roselle L. Cripps, Alastair S. Garfield, Zorica Jovanovic, Giuseppe D'Agostino, Giles S. H. Yeo, Michael A. Cawthorne, Jonathan R. S. Arch, Lora K. Heisler, Susan E. Ozanne
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 4, Pp 401-412 (2016)
Although obesity is a global epidemic, the physiological mechanisms involved are not well understood. Recent advances reveal that susceptibility to obesity can be programmed by maternal and neonatal nutrition. Specifically, a maternal low-protein die
Externí odkaz:
https://doaj.org/article/0d53f972d902400bac1f603ea96b7d98
Autor:
Luke K. Burke, Barbora Doslikova, Giuseppe D'Agostino, Megan Greenwald-Yarnell, Teodora Georgescu, Raffaella Chianese, Pablo B. Martinez de Morentin, Emmanuel Ogunnowo-Bada, Celine Cansell, Lourdes Valencia-Torres, Alastair S. Garfield, John Apergis-Schoute, Daniel D. Lam, John R. Speakman, Marcelo Rubinstein, Malcolm J. Low, Justin J. Rochford, Martin G. Myers, Mark L. Evans, Lora K. Heisler
Publikováno v:
Molecular Metabolism, Vol 5, Iss 3, Pp 245-252 (2016)
Objective: Obesity is one of the primary healthcare challenges of the 21st century. Signals relaying information regarding energy needs are integrated within the brain to influence body weight. Central among these integration nodes are the brain pro-
Externí odkaz:
https://doaj.org/article/c6e907e380bc4741a86d183bf11641af
Autor:
Giuseppe D'Agostino, Claudia Cristiano, David J. Lyons, Rita Citraro, Emilio Russo, Carmen Avagliano, Roberto Russo, Giuseppina Mattace Raso, Rosaria Meli, Giovambattista De Sarro, Lora K. Heisler, Antonio Calignano
Publikováno v:
Molecular Metabolism, Vol 4, Iss 7, Pp 528-536 (2015)
Background/objectives: Nuclear peroxisome proliferator activated receptor-α (PPAR-α) plays a fundamental role in the regulation of lipid homeostasis and is the target of medications used to treat dyslipidemia. However, little is known about the rol
Externí odkaz:
https://doaj.org/article/f13fbccde4d042ae8c7e2d62fe63717e