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Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation.

Autor: Ramos-Mondragon R; Department of Pharmacology and., Edokobi N; Department of Pharmacology and., Hodges SL; Department of Pharmacology and., Wang S; Department of Pharmacology and., Bouza AA; Department of Pharmacology and., Canugovi C; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Scheuing C; Department of Pharmacology and., Juratli L; Department of Pharmacology and., Abel WR; Department of Pharmacology and., Noujaim SF; Department of Molecular Pharmacology & Physiology, University of South Florida College of Medicine, Tampa, Florida, USA., Madamanchi NR; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Runge MS; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Lopez-Santiago LF; Department of Pharmacology and., Isom LL; Department of Pharmacology and.; Department of Neurology and.; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Publikováno v: JCI insight [JCI Insight] 2022 May 23; Vol. 7 (10). Date of Electronic Publication: 2022 May 23.

Correction: Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.

Autor: Nelson AD; Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA., Caballero-Florán RN; Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA., Díaz JCR; Neuroscience Graduate Program, University of Michigan, 48109, Ann Arbor, MI, USA., Hull JM; Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan, 48109, Ann Arbor, MI, USA., Yuan Y; Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA., Li J; Division of Life Sciences, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Chen K; Division of Life Sciences, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Walder KK; Department of Cell Biology, Duke University Medical Center, 27710, Durham, NC, USA., Lopez-Santiago LF; Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA., Bennett V; Department of Cell Biology, Duke University Medical Center, 27710, Durham, NC, USA.; Departments of Biochemistry, Neurobiology, and Howard Hughes Medical Institute, Duke University Medical Center, 27710, Durham, NC, USA., McInnis MG; Department of Psychiatry, University of Michigan, 48109, Ann Arbor, MI, USA., Isom LL; Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan, 48109, Ann Arbor, MI, USA.; Department of Neurology, University of Michigan, 48109, Ann Arbor, MI, USA.; Department of Molecular and Integrative Physiology, University of Michigan, 48109, Ann Arbor, MI, USA., Wang C; Division of Life Sciences, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China., Zhang M; Division of Life Sciences, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Jones KS; Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan, 48109, Ann Arbor, MI, USA., Jenkins PM; Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA. pjenkins@umich.edu.; Department of Psychiatry, University of Michigan, 48109, Ann Arbor, MI, USA. pjenkins@umich.edu.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2020 Nov; Vol. 25 (11), pp. 3106.

Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52.

Autor: Hull JM; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., O'Malley HA, Chen C; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Yuan Y; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Denomme N; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Bouza AA; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Anumonwo C; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Lopez-Santiago LF; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Isom LL; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

Publikováno v: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2020 Nov; Vol. 7 (11), pp. 2137-2149. Date of Electronic Publication: 2020 Sep 26.

Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S -palmitoylation, and regulated intramembrane proteolysis.

Autor: Bouza AA; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Philippe JM; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Edokobi N; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Pinsky AM; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Offord J; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Calhoun JD; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Lopez-Florán M; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Lopez-Santiago LF; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Jenkins PM; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA., Isom LL; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA lisom@umich.edu.; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2020 Jul 24; Vol. 295 (30), pp. 10380-10393. Date of Electronic Publication: 2020 Jun 05.