In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer.

Autor: Zagorac I; Breast Cancer Clinical Research Unit, CNIO - Spanish National Cancer Research Center, 28029, Madrid, Spain., Fernandez-Gaitero S; Breast Cancer Clinical Research Unit, CNIO - Spanish National Cancer Research Center, 28029, Madrid, Spain., Penning R; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.; Netherlands Proteomics Center, Padualaan 8, 3584 CH, Utrecht, The Netherlands., Post H; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.; Netherlands Proteomics Center, Padualaan 8, 3584 CH, Utrecht, The Netherlands., Bueno MJ; Breast Cancer Clinical Research Unit, CNIO - Spanish National Cancer Research Center, 28029, Madrid, Spain., Mouron S; Breast Cancer Clinical Research Unit, CNIO - Spanish National Cancer Research Center, 28029, Madrid, Spain., Manso L; Medical Oncology, Hospital 12 de Octubre, Madrid, 28029, Spain., Morente MM; Biobank, CNIO - Spanish National Cancer Research Center, Madrid, 28029, Spain., Alonso S; Pathology Department, Hospital Universitario de Guadalajara, Guadalajara, 19002, Spain., Serra V; Experimental Therapeutics Group, VHIO - Vall d'Hebron Institute of Oncology, Barcelona, 08035, Spain., Muñoz J; Proteomics Unit, CNIO - Spanish National Cancer Research Center, Madrid, 28029, Spain., Gómez-López G; Bioinformatics Unit, CNIO - Spanish National Cancer Research Center, Madrid, 28029, Spain., Lopez-Acosta JF; Breast Cancer Clinical Research Unit, CNIO - Spanish National Cancer Research Center, 28029, Madrid, Spain., Jimenez-Renard V; Breast Cancer Clinical Research Unit, CNIO - Spanish National Cancer Research Center, 28029, Madrid, Spain., Gris-Oliver A; Experimental Therapeutics Group, VHIO - Vall d'Hebron Institute of Oncology, Barcelona, 08035, Spain., Al-Shahrour F; Bioinformatics Unit, CNIO - Spanish National Cancer Research Center, Madrid, 28029, Spain., Piñeiro-Yañez E; Bioinformatics Unit, CNIO - Spanish National Cancer Research Center, Madrid, 28029, Spain., Montoya-Suarez JL; Medical Oncology, Hospital Nacional Guillermo Almenara Irigoyen - ESSALUD, Lima, 15033, Peru., Apala JV; Breast Cancer Clinical Research Unit, CNIO - Spanish National Cancer Research Center, 28029, Madrid, Spain., Moreno-Torres A; Pathology Department, Hospital Universitario de Fuenlabrada, Fuenlabrada, 28942, Spain., Colomer R; Medical Oncology, Hospital La Princesa, Madrid, 28006, Spain., Dopazo A; Genomics Unit, CNIC - Spanish National Center for Cardiovascular Research, Madrid, 28029, Spain., Heck AJR; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.; Netherlands Proteomics Center, Padualaan 8, 3584 CH, Utrecht, The Netherlands., Altelaar M; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.; Netherlands Proteomics Center, Padualaan 8, 3584 CH, Utrecht, The Netherlands., Quintela-Fandino M; Breast Cancer Clinical Research Unit, CNIO - Spanish National Cancer Research Center, 28029, Madrid, Spain. mquintela@cnio.es.; Medical Oncology, Hospital Universitario Fuenlabrada, Madrid, 28942, Spain. mquintela@cnio.es.; Medical Oncology, Hospital Universitario Quirón, Madrid, 28223, Spain. mquintela@cnio.es.

Publikováno v: Nature communications [Nat Commun] 2018 Aug 29; Vol. 9 (1), pp. 3501. Date of Electronic Publication: 2018 Aug 29.

Ghrelin's Effects on Proinflammatory Cytokine Mediated Apoptosis and Their Impact on β-Cell Functionality.

Autor: Diaz-Ganete A; Research Unit, Puerta del Mar University Hospital, 11009 Cadiz, Spain., Baena-Nieto G; Research Unit, Puerta del Mar University Hospital, 11009 Cadiz, Spain ; Department of Endocrinology and Nutrition, Jerez de la Frontera General Hospital, 11407 Jerez de la Frontera, Spain., Lomas-Romero IM; Research Unit, Puerta del Mar University Hospital, 11009 Cadiz, Spain ; Andalusian Cellular Reprogramming Laboratory, 41092 Sevilla, Spain., Lopez-Acosta JF; Research Unit, Puerta del Mar University Hospital, 11009 Cadiz, Spain ; Genetics and Molecular Biology Research Institute, University of Valladolid-CSIC, 47003 Valladolid, Spain., Cozar-Castellano I; Genetics and Molecular Biology Research Institute, University of Valladolid-CSIC, 47003 Valladolid, Spain., Medina F; Research Unit, Puerta del Mar University Hospital, 11009 Cadiz, Spain ; Salus Infirmorum Faculty of Nursing, Cadiz University, 11001 Cadiz, Spain., Segundo C; Research Unit, Puerta del Mar University Hospital, 11009 Cadiz, Spain ; Salus Infirmorum Faculty of Nursing, Cadiz University, 11001 Cadiz, Spain., Lechuga-Sancho AM; Research Unit, Puerta del Mar University Hospital, 11009 Cadiz, Spain ; Department of Maternal and Pediatric Medicine and Radiology, Pediatrics Unit, Puerta del Mar University Hospital, 11009 Cadiz, Spain.

Publikováno v: International journal of endocrinology [Int J Endocrinol] 2015; Vol. 2015, pp. 235727. Date of Electronic Publication: 2015 Jul 16.

Pharmacological activation of insulin‐degrading enzyme improves insulin secretion and glucose tolerance in diet‐induced obese mice.

Autor: Sanz‐González, Alba, Cózar‐Castellano, Irene, Broca, Christophe, Sabatier, Julia, Acosta, Gerardo A., Royo, Miriam, Hernándo‐Muñoz, Carla, Torroba, Tomás, Perdomo, Germán, Merino, Beatriz

Publikováno v: Diabetes, Obesity & Metabolism; Nov2023, Vol. 25 Issue 11, p3268-3278, 11p

Emerging roles for the amyloid precursor protein and derived peptides in the regulation of cellular and systemic metabolism.

Autor: Czeczor, J. K.^1,2,3, McGee, S. L.¹ sean.mcgee@deakin.edu.au

Publikováno v: Journal of Neuroendocrinology. May2017, Vol. 29 Issue 5, p1-N.PAG. 8p.

Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1.

Autor: Knight, Elysse M.¹, Ruiz, Henry H.², Soong Ho Kim¹, Harte, Jessica C.^1,3, Hsieh, Wilson², Glabe, Charles^4,5, Klein, William L.⁶, Attie, Alan D.⁷, Buettner, Christoph², Ehrlich, Michelle E.³, Gandy, Sam^1,8 samuel.gandy@mssm.edu

Publikováno v: Acta Neuropathologica Communications. 2/25/2016, Vol. 4, p1-15. 15p.