Výsledky vyhledávání - "Lopez, Michael S"

Akademický článek

Host-derived fatty acids activate type VII secretion in Staphylococcus aureus

Autor: Lopez, Michael S., Tan, Irene S., Yan, Donghong, Kang, Jing, McCreary, Mark, Modrusan, Zora, Austin, Cary D., Xu, Min, Brown, Eric J.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2017 Oct . 114(42), 11223-11228.

Externí odkaz: https://www.jstor.org/stable/26488945

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Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii

Autor: Rutaganira, Florentine U, Barks, Jennifer, Dhason, Mary Savari, Wang, Qiuling, Lopez, Michael S, Long, Shaojun, Radke, Joshua B, Jones, Nathaniel G, Maddirala, Amarendar R, Janetka, James W, El Bakkouri, Majida, Hui, Raymond, Shokat, Kevan M, Sibley, L David

Publikováno v: Journal of medicinal chemistry, vol 60, iss 24

Calcium dependent protein kinase 1 (CDPK1) is an essential enzyme in the opportunistic pathogen Toxoplasma gondii. CDPK1 controls multiple processes that are critical to the intracellular replicative cycle of T. gondii including secretion of adhesins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::c51822408267749c451fbebfd7beb6b9
https://escholarship.org/uc/item/4vp5t8v5

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Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy

Autor: Warkentin, Alexander A, Lopez, Michael S, Lasater, Elisabeth A, Lin, Kimberly, He, Bai-Liang, Leung, Anskar Yh, Smith, Catherine C, Shah, Neil P, Shokat, Kevan M

Activating mutations in FLT3 confer poor prognosis for individuals with acute myeloid leukemia (AML). Clinically active investigational FLT3 inhibitors can achieve complete remissions but their utility has been hampered by acquired resistance and mye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::afc1eee1544a394f00bb5ce6a17dc1e6
https://escholarship.org/uc/item/1gd1n0mp

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Responses to glial cell line-derived neurotrophic factor change in mice as spermatogonial stem cells form progenitor spermatogonia which replicate and give rise to more differentiated progeny

Autor: Parker, Nicole, Falk, Hayley, Singh, Dolly, Fidaleo, Anthony, Smith, Benjamin, Lopez, Michael S, Shokat, Kevan M, Wright, William W

Publikováno v: Biology of reproduction, vol 91, iss 4

Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis. These cells are classically defined as a subset of morphologically defined A single (As) spermatogonia, which can produce more SSCs or they can give rise to nonstem As cells that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::d732287f2cd197a50a447ccc4bbe73c4
https://escholarship.org/uc/item/1fv4m6k2

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Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology

Autor: Lopez, Michael S, Choy, Jonathan W, Peters, Ulf, Sos, Martin L, Morgan, David O, Shokat, Kevan M

Publikováno v: Journal of the American Chemical Society, vol 135, iss 48

Analog-sensitive (AS) kinase technology is a powerful approach for studying phospho-signaling pathways in diverse organisms and physiological processes. The key feature of this technique is that a kinase-of-interest can be mutated to sensitize it to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::83a70983fca935470e73a0f4b59283a6
https://escholarship.org/uc/item/00q4b12n

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Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology

Autor: Zhang, Chao, Lopez, Michael S, Dar, Arvin C, Ladow, Eva, Finkbeiner, Steven, Yun, Cai-Hong, Eck, Michael J, Shokat, Kevan M

Publikováno v: ACS chemical biology, vol 8, iss 9

Engineered analog-sensitive (AS) protein kinases have emerged as powerful tools for dissecting phospho-signaling pathways, for elucidating the cellular function of individual kinases, and for deciphering unanticipated effects of clinical therapeutics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::204a41b353d873d95c1a089f235cfea6
https://escholarship.org/uc/item/46s8z3g7

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