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Differential effects of the essential oils of Lavandula luisieri and Eryngium duriaei subsp. juresianum in cell models of two chronic inflammatory diseases

Autor: Rufino, AT, Ferreira, I, Judas, F, Salgueiro, L, Lopes, MC, Cavaleiro, C, Mendes, AF

CONTEXT: Effective drugs to treat osteoarthritis (OA) and inflammatory bowel disease (IBD) are needed. OBJECTIVE: To identify essential oils (EOs) with anti-inflammatory activity in cell models of OA and IBD. MATERIALS AND METHODS: EOs from Eryngium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1504::2bf61ea923e8b1828d83a0238d2614d5
https://hdl.handle.net/10400.4/1849

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Purification, Chemical, and Immunochemical Properties of a New Lectin fromMimosoideae (Parkia Discolor)

Autor: Thalles B. Grangeiro, Luis A. G. Souza, Dantas Ar, Márcio V. Ramos, K B Leite, Benildo Sousa Cavada, V.P.T. Pinto, Bomfim Lr, Juan J. Calvete, Beatriz Tupinamba Freitas, Madeira Svf, Lopes Mc

Publikováno v: Preparative Biochemistry and Biotechnology. 30:271-280

A glucose/mannose-binding lectin was isolated from seeds of Parkia discolor (Mimosoideae) using affinity chromatography on Sephadex G-100 gel. The protein presented a unique component in SDS-PAGE corresponding to a molecular mass of 58,000 Da, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770aaaac09408703c5a55e1f4f2d4ad2
https://doi.org/10.1080/10826060008544966

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Amplified and Homozygously Deleted Genes in Glioblastoma: Impact on Gene Expression Levels

Autor: Crespo, I, Tão, H, Nieto, AB, Rebelo, O, Domingos, P, Vital, AL, Patino, MC, Barbosa, MD, Lopes, MC, Resende de Oliveira, C, Orfão, A, Tabernero, MD

BACKGROUND: Glioblastoma multiforme (GBM) displays multiple amplicons and homozygous deletions that involve relevant pathogenic genes and other genes whose role remains unknown. METHODOLOGY: Single-nucleotide polymorphism (SNP)-arrays were used to de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1504::74e7ee843ec4f37e29c60194f249fc02
https://hdl.handle.net/10400.4/1528

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Signal transduction profile of chemical sensitisers in dendritic cells: an endpoint to be included in a cell-based in vitro alternative approach to hazard identification?

Autor: Neves, BM, Gonçalo, Margarida, Figueiredo, A, Duarte, CB, Lopes, MC, Cruz, MT

The development of non-animal testing methods for the assessment of skin sensitisation potential is an urgent challenge within the framework of existing and forthcoming legislation. Efforts have been made to replace current animal tests, but so far n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1504::91bc753a570856222e2476c9774d4b8f
https://hdl.handle.net/10400.4/1328

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Screening of five essential oils for identification of potential inhibitors

Autor: Neves, A, Rosa, S, Gonçalves, J, Rufino, A, Judas, F, Salgueiro, L, Lopes, MC, Cavaleiro, C, Mendes, AF

Nuclear factor-kappaB is a key transcription factor activated by pro-inflammatory signals, like interleukin-1beta (IL-1), being required for the expression of many inflammatory and catabolic mediators, such as nitric oxide (NO), that play an importan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1504::c4166db53d2f93734b2c2e48ddf8b89a
https://hdl.handle.net/10400.4/1196

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Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes

Autor: Rosa, SC, Rufino, AT, Judas, F, Tenreiro, CM, Lopes, MC, Mendes, AF

Cartilage matrix homeostasis involves a dynamic balance between numerous signals that modulate chondrocyte functions. This study aimed at elucidating the role of the extracellular glucose concentration in modulating anabolic and catabolic gene expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1504::898ee174fc52faa8b123fded68dcbfef
https://hdl.handle.net/10400.4/1208

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Effect of lipopolysaccharide, skin sensitizers and irritants on thioredoxin-1 expression in dendritic cells: relevance of different signalling pathways

Autor: Francisco, V, Neves, BM, Cruz, MT, Gonçalo, Margarida, Figueiredo, A, Duarte, CB, Lopes, MC

Thioredoxin-1 is a ubiquitous protein involved in phenotypical and functional changes in dendritic cells (DC). We investigated the effect of lipopolysaccharide (LPS), skin sensitizers, and irritants on thioredoxin-1 by Western blot and immunofluoresc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1504::858128388153ec77baa0a323eaffcaa5
https://hdl.handle.net/10400.4/994

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Nitric oxide synthase isoforms and NF-kappaB activity in normal and osteoarthritic human chondrocytes: regulation by inducible nitric oxide

Autor: Rosa, SC, Judas, F, Lopes, MC, Mendes, AF

To elucidate the role of endogenous inducible nitric oxide (NO) on the regulation of NF-kappaB activity in human chondrocytes, we evaluated (i) the pattern of expression of the neuronal (nNOS) and inducible (iNOS) NO synthase isoforms and the basal N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1504::ffa82e8e693789bda7fe4015dfd96a8f
https://hdl.handle.net/10400.4/1181

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