Výsledky vyhledávání - "Lopes Bernardes, GJ"

Radical-mediated thiol-ene strategy for photoactivation of thiol-containing drugs in cancer cells

Autor: Lopes Bernardes, GJ

Photo-activated drugs provide an opportunity to improve efficacy alongside reducing side-effects in the treatment of severe diseases, such as cancer. Herein, we describe a photoactivation decaging method of isobutylene-caged thiols through a UV-initi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9d9e580eb45f906c8ed56e6cd6402d
https://www.repository.cam.ac.uk/handle/1810/285696

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Oxetane grafts site-selectively installed on native disulfides enhance protein stability and activity in vivo

Autor: Martínez-Sáez, N, Sun, S, Oldrini, D, Sormanni, P, Boutureira, O, Carboni, F, Compañón, I, Deery, MJ, Vendruscolo, M, Corzana, F, Adamo, R, Lopes Bernardes, GJ

Here we show that a four-membered oxygen ring – oxetane – can be readily grafted into native peptides and proteins through site-selective bis-alkylation of cysteine residues present as disulfides under mild and biocompatible conditions. The selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a866f17bc580fff402e6c93a1cc2eb
https://www.repository.cam.ac.uk/handle/1810/273533

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Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils

Autor: Lopes Bernardes, GJ

Mercury pollution threatens the environment and human health across the globe. This neurotoxic substance is encountered in artisanal gold mining, coal combustion, oil and gas refining, waste incineration, chloralkali plant operation, metallurgy, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58e206838f8ef09288e3f8c156221ff

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The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer

Autor: Somovilla, VJ, Bermejo, IA, Albuquerque, IS, Martínez-Sáez, N, Castro-López, J, García-Martín, F, Compañón, I, Hinou, H, Nishimura, S, Jiménez-Barbero, J, Asensio, JL, Avenoza, A, Busto, Hurtado-Guerrero, R, Peregrina, JM, Lopes Bernardes, GJ, Corzana1, F

A structure-based design of a new gene22ration tumor-associated glycopeptides with improved affinity against two anti-MUC1 antibodies is described. These unique antigens feature a fluorinated proline residue, such as a (4S)-4-fluoro-L-proline or 4,4-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5ac8b256bc36700541e187fd83ca012

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Site-Selective Modification of Proteins with Oxetanes

Autor: Boutureira, O, Martínez-Sáez, N, Brindle, KM, Neves, AA, Corzana, F, Lopes Bernardes, GJ

Oxetanes are four-membered ring oxygen heterocycles that are advantageously used in medicinal chemistry as modulators of physicochemical properties of small molecules. Herein, we present a simple method for the incorporation of oxetanes into proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::add9f4d9bfb5d9754c035060b7c1be85

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