The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose

Autor: Hua Rong Lu, Bruce P. Damiano, Mohamed Kreir, Jutta Rohrbacher, Henk van der Linde, Tamerlan Saidov, Ard Teisman, David J. Gallacher

Publikováno v: Biomolecules, Vol 13, Iss 9, p 1355 (2023)

Loperamide has been a safe and effective treatment for diarrhea for many years. However, many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently been reported. We evaluated loperamide in in vitro and in vivo cardiac

Externí odkaz: https://doaj.org/article/c7cdd87a46974314ad2466c9c4b2542c

Ventricular fibrillation due to overdose of loperamide, the 'poor man’s methadone'

Autor: Amr Salama, Yana Levin, Pramod Jha, Richard Alweis

Publikováno v: Journal of Community Hospital Internal Medicine Perspectives, Vol 7, Iss 4, Pp 222-226 (2017)

Loperamide is an over-the-counter antidiarrheal agent that is considered by many patients to be safe, but has been used as a drug of abuse due to its opioid properties. However, cardiotoxicity has been reported, prompting the FDA to release a warning

Externí odkaz: https://doaj.org/article/9b1c797a280f40d3b4643b139861a056

‘ Loperamide overdose induces ventricular tachycardia with catastrophic outcomes’

Autor: Sohaib Roomi, Zain Ali, Umer Shoukat, Waqas Ullah, Mariya Khan

Publikováno v: Journal of Community Hospital Internal Medicine Perspectives, Vol 10, Iss 3, Pp 229-232 (2020)
Journal of Community Hospital Internal Medicine Perspectives
article-version (VoR) Version of Record

Loperamide is a widely available, over-the-counter medication. The advent of the opioid epidemic has seen cases of loperamide overdose being reported. The common side effects of the medication can be relatively benign, but at high doses, loperamide c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5faa1747a4b89225e666d096c817d36
https://doaj.org/article/e934b6052be04d9e9e451f7b54d4f938

Left Ventricular Regional Wall Motion Abnormality in the Setting of Acute Loperamide Overdose

Autor: Timonthy Montrief, Kasha Bornstein, Mehruba Anwar Parris

Publikováno v: Clinical Practice and Cases in Emergency Medicine, Vol 3, Iss 3 (2019)
Bornstein, Kasha; Montrief, Timonthy; & Anwar Parris, Mehruba. (2019). Left Ventricular Regional Wall Motion Abnormality in the Setting of Acute Loperamide Overdose. Clinical Practice and Cases in Emergency Medicine, Advance online publication. Retrieved from: http://www.escholarship.org/uc/item/9hm8j0jn
Clinical Practice and Cases in Emergency Medicine

Loperamide is an inexpensive, over-the-counter antidiarrheal agent with emerging reports of overdose due to its opioid properties. Although it is considered by many patients to be safe, cardiotoxicity has been reported, prompting the United States Fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc3c5d7a8930ade9ecbc798e1e2676a
https://doi.org/10.5811/cpcem.2019.4.42510

Takotsubo-Like Cardiomyopathy After Loperamide Overdose

Autor: Kinner Patel, Dinesh Subedi, Siddharth Shah

Publikováno v: American Journal of Therapeutics. 25:e548-e550

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b005526b9638d29cb6bc1f290dd2ca5c
https://doi.org/10.1097/mjt.0000000000000595