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PD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) cell plasticity associated to immune checkpoint inhibitor (ICI)-mediated hyperprogressive disease (HPD).

Autor: Angelicola S; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Laboratory of Immunology and Biology of Metastasis, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Giunchi F; Pathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Ruzzi F; Laboratory of Immunology and Biology of Metastasis, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Frascino M; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Pitzalis M; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Scalambra L; Laboratory of Immunology and Biology of Metastasis, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Semprini MS; Laboratory of Immunology and Biology of Metastasis, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Pittino OM; Laboratory of Immunology and Biology of Metastasis, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Cappello C; Laboratory of Immunology and Biology of Metastasis, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Siracusa I; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Chillico IC; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Di Noia M; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Turato C; Department of Molecular Medicine, University of Pavia, Pavia, Italy., De Siervi S; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Lescai F; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy., Ciavattini T; Department of Biotechnology, University of Verona, Verona, Italy., Lopatriello G; Department of Biotechnology, University of Verona, Verona, Italy., Bertoli L; Department of Biotechnology, University of Verona, Verona, Italy., De Jonge H; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Iamele L; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Altimari A; Solid Tumor Molecular Pathology Laboratory, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Gruppioni E; Solid Tumor Molecular Pathology Laboratory, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Ardizzoni A; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Rossato M; Department of Biotechnology, University of Verona, Verona, Italy.; Genartis S.R.L., Verona, Italy., Gelsomino F; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. francesco_gelsomino@aosp.bo.it., Lollini PL; Laboratory of Immunology and Biology of Metastasis, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.; IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy., Palladini A; Department of Molecular Medicine, University of Pavia, Pavia, Italy. arianna.palladini@unipv.it.; Unità Operativa di Oncologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. arianna.palladini@unipv.it.

Publikováno v: Journal of translational medicine [J Transl Med] 2025 Jan 02; Vol. 23 (1), pp. 2. Date of Electronic Publication: 2025 Jan 02.