Tumor cell-intrinsic and tumor microenvironmental conditions co-determine signaling by the glycoimmune checkpoint receptor Siglec-7.

Autor: van Houtum EJH; Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Post 874, 6525 GA, Nijmegen, The Netherlands., Kers-Rebel ED; Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Post 874, 6525 GA, Nijmegen, The Netherlands., Looman MW; Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Post 874, 6525 GA, Nijmegen, The Netherlands., Hooijberg E; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Büll C; Department of Biomolecular Chemistry, Institute for Molecules and Materials, Radboud University Nijmegen, Nijmegen, The Netherlands., Granado D; Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Post 874, 6525 GA, Nijmegen, The Netherlands., Cornelissen LAM; Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Post 874, 6525 GA, Nijmegen, The Netherlands., Adema GJ; Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Post 874, 6525 GA, Nijmegen, The Netherlands. gosse.adema@radboudumc.nl.

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2023 May 30; Vol. 80 (6), pp. 169. Date of Electronic Publication: 2023 May 30.

Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma.

Autor: Kroesen M; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Pediatric Oncology, Radboud University Medical Center, Nijmegen, The Netherlands., Büll C; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen, The Netherlands., Gielen PR; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen, The Netherlands., Brok IC; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen, The Netherlands., Armandari I; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen, The Netherlands., Wassink M; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen, The Netherlands., Looman MW; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen, The Netherlands., Boon L; EPIRUS Biopharmaceuticals Netherlands B.V. , Utrecht, The Netherlands., den Brok MH; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen, The Netherlands., Hoogerbrugge PM; Department of Pediatric Oncology, Radboud University Medical Center, Nijmegen, The Netherlands; Princes Máxima Center for Pediatric Oncology, De Bilt, The Netherlands., Adema GJ; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen, The Netherlands.

Publikováno v: Oncoimmunology [Oncoimmunology] 2016 Mar 28; Vol. 5 (6), pp. e1164919. Date of Electronic Publication: 2016 Mar 28 (Print Publication: 2016).

DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells.

Autor: Ansems M; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands, Marleen.Ansems@radboudumc.nl., Søndergaard JN, Sieuwerts AM, Looman MW, Smid M, de Graaf AM, de Weerd V, Zuidscherwoude M, Foekens JA, Martens JW, Adema GJ

Publikováno v: Breast cancer research and treatment [Breast Cancer Res Treat] 2015 Feb; Vol. 149 (3), pp. 693-703. Date of Electronic Publication: 2015 Feb 08.

DC-SCRIPT regulates glucocorticoid receptor function and expression of its target GILZ in dendritic cells.

Autor: Hontelez S; Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands., Karthaus N, Looman MW, Ansems M, Adema GJ

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2013 Apr 01; Vol. 190 (7), pp. 3172-9. Date of Electronic Publication: 2013 Feb 25.

Dendritic cell-specific transcript: dendritic cell marker and regulator of TLR-induced cytokine production.

Autor: Hontelez S; Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands., Ansems M, Karthaus N, Zuidscherwoude M, Looman MW, Triantis V, Adema GJ

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2012 Jul 01; Vol. 189 (1), pp. 138-45. Date of Electronic Publication: 2012 May 21.