Predicting the presence of coronary plaques featuring high-risk characteristics using polygenic risk scores and targeted proteomics in patients with suspected coronary artery disease

Autor: Peter Loof Møller, Palle Duun Rohde, Jonathan Nørtoft Dahl, Laust Dupont Rasmussen, Louise Nissen, Samuel Emil Schmidt, Victoria McGilligan, Daniel F. Gudbjartsson, Kari Stefansson, Hilma Holm, Jacob Fog Bentzon, Morten Bøttcher, Simon Winther, Mette Nyegaard

Publikováno v: Genome Medicine, Vol 16, Iss 1, Pp 1-10 (2024)

Abstract Background The presence of coronary plaques with high-risk characteristics is strongly associated with adverse cardiac events beyond the identification of coronary stenosis. Testing by coronary computed tomography angiography (CCTA) enables

Externí odkaz: https://doaj.org/article/7e2e1d0fe7b24c7ba780a6987ace137d

Sortilin as a Biomarker for Cardiovascular Disease Revisited

Autor: Peter Loof Møller, Palle D. Rohde, Simon Winther, Peter Breining, Louise Nissen, Anders Nykjaer, Morten Bøttcher, Mette Nyegaard, Mads Kjolby

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Genetic variants in the genomic region containing SORT1 (encoding the protein sortilin) are strongly associated with cholesterol levels and the risk of coronary artery disease (CAD). Circulating sortilin has therefore been proposed as a potential bio

Externí odkaz: https://doaj.org/article/27e18251f29a48769c3fe14445e2cc0f

Diagnostic Yield of Genetic Testing in Young Patients With Atrioventricular Block of Unknown Cause.

Autor: Resdal Dyssekilde J; Department of Cardiology Aarhus University Hospital Aarhus Denmark., Frederiksen TC; Department of Cardiology Aarhus University Hospital Aarhus Denmark.; Department of Clinical Medicine Health Aarhus University Aarhus Denmark., Christiansen MK; Department of Cardiology Aarhus University Hospital Aarhus Denmark., Hasle Sørensen R; Department of Molecular Medicine Aarhus University Hospital Aarhus Denmark., Pedersen LN; Department of Molecular Medicine Aarhus University Hospital Aarhus Denmark., Loof Møller P; Department of Biomedicine Health Aarhus University Aarhus Denmark., Christensen LS; Department of Cardiology Hospital of Southern Jutland Aabenraa Denmark., Larsen JM; Department of Cardiology Aalborg University Hospital Aalborg Denmark., Thomsen KK; Department of Cardiology Hospital South West Jutland Esbjerg Denmark., Lindhardt TB; Department of Cardiology Copenhagen University HospitalHerlev and Gentofte Hospital Hellerup Denmark., Böttcher M; Department of Cardiology Regional Hospital Herning Herning Denmark., Molsted S; Department of Clinical Research North Zealand Hospital Hillerød Denmark., Havndrup O; Department of Cardiology Zealand University Hospital Roskilde Denmark., Fischer T; Department of Cardiology Vejle Hospital Vejle Denmark., Møller DS; Department of Cardiology Regional Hospital Central Jutland Viborg Denmark., Henriksen FL; Department of Cardiology Odense University Hospital Odense Denmark., Johansen JB; Department of Cardiology Odense University Hospital Odense Denmark., Nielsen JC; Department of Cardiology Aarhus University Hospital Aarhus Denmark.; Department of Clinical Medicine Health Aarhus University Aarhus Denmark., Bundgaard H; Department of Cardiology The Heart Center Rigshospitalet Copenhagen Denmark.; Department of Clinical Medicine University of Copenhagen Denmark., Nygaard M; Department of Biomedicine Health Aarhus University Aarhus Denmark.; Department of Health Science and Technology Aalborg Denmark., Jensen HK; Department of Cardiology Aarhus University Hospital Aarhus Denmark.; Department of Clinical Medicine Health Aarhus University Aarhus Denmark.

Publikováno v: Journal of the American Heart Association [J Am Heart Assoc] 2022 May 03; Vol. 11 (9), pp. e025643. Date of Electronic Publication: 2022 Apr 26.