FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro .

Autor: Lau HH; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Proteos, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Amirruddin NS; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Proteos, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Loo LSW; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Proteos, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Chan JW; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Proteos, Singapore, Singapore., Iich E; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Proteos, Singapore, Singapore., Krishnan VG; Molecular Engineering Lab, IMCB, Proteos, Singapore, Singapore., Hoon S; Molecular Engineering Lab, IMCB, Proteos, Singapore, Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Proteos, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Precision Medicine Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Publikováno v: IScience [iScience] 2023 Jul 03; Vol. 26 (8), pp. 107265. Date of Electronic Publication: 2023 Jul 03 (Print Publication: 2023).

Brief exposure to directionally-specific pulsed electromagnetic fields stimulates extracellular vesicle release and is antagonized by streptomycin: A potential regenerative medicine and food industry paradigm.

Autor: Wong CJK; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore; Institute of Health Technology and Innovation (iHealthtech), National University of Singapore, 117599, Singapore; Biolonic Currents Electromagnetic Pulsing Systems Laboratory (BICEPS), National University of Singapore, 117599, Singapore., Tai YK; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore; Institute of Health Technology and Innovation (iHealthtech), National University of Singapore, 117599, Singapore; Biolonic Currents Electromagnetic Pulsing Systems Laboratory (BICEPS), National University of Singapore, 117599, Singapore. Electronic address: surtaiyk@nus.edu.sg., Yap JLY; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore; Institute of Health Technology and Innovation (iHealthtech), National University of Singapore, 117599, Singapore; Biolonic Currents Electromagnetic Pulsing Systems Laboratory (BICEPS), National University of Singapore, 117599, Singapore., Fong CHH; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore; Institute of Health Technology and Innovation (iHealthtech), National University of Singapore, 117599, Singapore; Biolonic Currents Electromagnetic Pulsing Systems Laboratory (BICEPS), National University of Singapore, 117599, Singapore., Loo LSW; Institute of Bioengineering and Bioimaging, A*STAR, The Nanos, #06-01, 31 Biopolis Way, 138669, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117593, Singapore., Kukumberg M; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore., Fröhlich J; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore; Fields at Work GmbH, Zurich 8032, Switzerland., Zhang S; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore; Nanomedicine Translational Research Programme, Centre for NanoMedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Li JZ; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore., Wang JW; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117593, Singapore; Nanomedicine Translational Research Programme, Centre for NanoMedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, National University Heart Centre Singapore, Singapore, 119074, Singapore., Rufaihah AJ; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore; School of Applied Sciences, Temasek Polytechnic, 529757, Singapore., Franco-Obregón A; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore; Institute of Health Technology and Innovation (iHealthtech), National University of Singapore, 117599, Singapore; Biolonic Currents Electromagnetic Pulsing Systems Laboratory (BICEPS), National University of Singapore, 117599, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117593, Singapore; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore; Nanomedicine Translational Research Programme, Centre for NanoMedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, 117599, Singapore. Electronic address: suraf@nus.edu.sg.

Publikováno v: Biomaterials [Biomaterials] 2022 Aug; Vol. 287, pp. 121658. Date of Electronic Publication: 2022 Jul 06.

Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation.

Autor: Teo AKK; Section of Islet Cell and Regenerative Biology, Department of Medicine, Joslin Diabetes Center, Brigham and Women's Hospital, Harvard Medical School, and Harvard Stem Cell Institute, Boston, Massachusetts, USA; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore, Singapore; Department of Biochemistry and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address: drainteo@gmail.com., Nguyen L; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore, Singapore; Department of Biochemistry and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Gupta MK; Section of Islet Cell and Regenerative Biology, Department of Medicine, Joslin Diabetes Center, Brigham and Women's Hospital, Harvard Medical School, and Harvard Stem Cell Institute, Boston, Massachusetts, USA., Lau HH; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Loo LSW; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Jackson N; Section of Islet Cell and Regenerative Biology, Department of Medicine, Joslin Diabetes Center, Brigham and Women's Hospital, Harvard Medical School, and Harvard Stem Cell Institute, Boston, Massachusetts, USA., Lim CS; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore, Singapore., Mallard W; Department of Stem Cell and Regenerative Biology, Harvard University, and Broad Institute of MIT, Cambridge, Massachusetts, USA., Gritsenko MA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Rinn JL; Department of Stem Cell and Regenerative Biology, Harvard University, and Broad Institute of MIT, Cambridge, Massachusetts, USA., Smith RD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Qian WJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Kulkarni RN; Section of Islet Cell and Regenerative Biology, Department of Medicine, Joslin Diabetes Center, Brigham and Women's Hospital, Harvard Medical School, and Harvard Stem Cell Institute, Boston, Massachusetts, USA. Electronic address: rohit.kulkarni@joslin.harvard.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100495. Date of Electronic Publication: 2021 Mar 03.

Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors.

Autor: Loo LSW; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A*STAR, Singapore.; School of Biological Sciences, Nanyang Technological University (NTU), Singapore., Vethe H; Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway., Soetedjo AAP; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A*STAR, Singapore., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts., Jasmen J; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A*STAR, Singapore., Jackson N; Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts., Bjørlykke Y; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway., Valdez IA; Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts., Vaudel M; Proteomics Unit (PROBE), Department of Biomedicine, University of Bergen, Bergen, Norway., Barsnes H; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.; Proteomics Unit (PROBE), Department of Biomedicine, University of Bergen, Bergen, Norway., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts., Raeder H; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics, Haukeland University Hospital, Bergen, Norway., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A*STAR, Singapore.; School of Biological Sciences, Nanyang Technological University (NTU), Singapore.; Departments of Biochemistry and Medicine, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore., Kulkarni RN; Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.

Publikováno v: Stem cells (Dayton, Ohio) [Stem Cells] 2020 Apr; Vol. 38 (4), pp. 542-555. Date of Electronic Publication: 2020 Jan 22.

An arduous journey from human pluripotent stem cells to functional pancreatic β cells.

Autor: Loo LSW; Programme in Stem Cell, Regenerative Medicine and Ageing, Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Lau HH; Programme in Stem Cell, Regenerative Medicine and Ageing, Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Singapore, Singapore., Jasmen JB; Programme in Stem Cell, Regenerative Medicine and Ageing, Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Singapore, Singapore., Lim CS; Programme in Stem Cell, Regenerative Medicine and Ageing, Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Singapore, Singapore., Teo AKK; Programme in Stem Cell, Regenerative Medicine and Ageing, Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Publikováno v: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2018 Jan; Vol. 20 (1), pp. 3-13. Date of Electronic Publication: 2017 Jun 07.