EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells

Autor: Grainger, Stephanie, Nguyen, Nicole, Richter, Jenna, Setayesh, Jordan, Lonquich, Brianna, Oon, Chet Huan, Wozniak, Jacob M, Barahona, Rocio, Kamei, Caramai N, Houston, Jack, Carrillo-Terrazas, Marvic, Drummond, Iain A, Gonzalez, David, Willert, Karl, Traver, David

Publikováno v: Nature cell biology, vol 21, iss 6

Wnt signalling drives many processes in development, homeostasis and disease; however, the role and mechanism of individual ligand-receptor (Wnt-Frizzled (Fzd)) interactions in specific biological processes remain poorly understood. Wnt9a is specific

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https://escholarship.org/uc/item/60v2b0gj

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EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells.

Autor: Grainger S; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Nguyen N; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Richter J; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA., Setayesh J; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Lonquich B; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Oon CH; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Wozniak JM; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, La Jolla, CA, USA.; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Barahona R; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Kamei CN; Massachusetts General Hospital Nephrology Division, Charlestown, MA, USA., Houston J; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA., Carrillo-Terrazas M; Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, La Jolla, CA, USA.; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Drummond IA; Massachusetts General Hospital Nephrology Division, Charlestown, MA, USA.; Harvard Medical School, Department of Genetics, Boston, MA, USA., Gonzalez D; Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, La Jolla, CA, USA.; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Willert K; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA. kwillert@ucsd.edu., Traver D; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA. dtraver@ucsd.edu.; Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA. dtraver@ucsd.edu.

Publikováno v: Nature cell biology [Nat Cell Biol] 2019 Jun; Vol. 21 (6), pp. 721-730. Date of Electronic Publication: 2019 May 20.