Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Lonny R Levin"'
Autor:
Eric Salazar, Erin M Bank, Nicole Ramsey, Kenneth C Hess, Kirk W Deitsch, Lonny R Levin, Jochen Buck
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39769 (2012)
The most severe form of human malaria is caused by the parasite Plasmodium falciparum. The second messenger cAMP has been shown to be important for the parasite's ability to infect the host's liver, but its role during parasite growth inside erythroc
Externí odkaz:
https://doaj.org/article/a51189cb507b46b4904d2127662aa690
Autor:
Thomas R Kolodecik, Christine A Shugrue, Edwin C Thrower, Lonny R Levin, Jochen Buck, Fred S Gorelick
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41320 (2012)
An early feature of acute pancreatitis is activation of zymogens, such as trypsinogen, within the pancreatic acinar cell. Supraphysiologic concentrations of the hormone cholecystokinin (CCK; 100 nM), or its orthologue cerulein (CER), induce zymogen a
Externí odkaz:
https://doaj.org/article/b86bb9574ccb44619b53e44daa82011a
Autor:
Rebecca A Hall, Luisa De Sordi, Donna M Maccallum, Hüsnü Topal, Rebecca Eaton, James W Bloor, Gary K Robinson, Lonny R Levin, Jochen Buck, Yue Wang, Neil A R Gow, Clemens Steegborn, Fritz A Mühlschlegel
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001193 (2010)
When colonising host-niches or non-animated medical devices, individual cells of the fungal pathogen Candida albicans expand into significant biomasses. Here we show that within such biomasses, fungal metabolically generated CO(2) acts as a communica
Externí odkaz:
https://doaj.org/article/640555169cd941a6b4d4724fa706606f
Autor:
Jeanne Farrell, Lavoisier Ramos, Martin Tresguerres, Margarita Kamenetsky, Lonny R Levin, Jochen Buck
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3251 (2008)
Mammalian Soluble adenylyl cyclase (sAC, Adcy10, or Sacy) represents a source of the second messenger cAMP distinct from the widely studied, G protein-regulated transmembrane adenylyl cyclases. Genetic deletion of the second through fourth coding exo
Externí odkaz:
https://doaj.org/article/c2df02c708ae44928649b122d1d5d41e
Autor:
Melanie Balbach, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Carla Ritagliati, Robert W. Myers, David J. Huggins, Clemens Steegborn, Ileana C. Miranda, Peter T. Meinke, Jochen Buck, Lonny R. Levin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Half of all pregnancies are unintended; thus, existing family planning options are inadequate. This proof-of-concept study validates an on-demand contraception strategy for men, showing high effectiveness in quickly and temporarily reducing male fert
Externí odkaz:
https://doaj.org/article/95c1debb563241228352ba4e29c74a64
Autor:
Ana Romarowski, Jasna Fejzo, Saman Nayyab, David Martin-Hidalgo, Maria G. Gervasi, Melanie Balbach, Sara Violante, Ana M. Salicioni, Justin Cross, Lonny R. Levin, Jochen Buck, Pablo E. Visconti
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Mammalian sperm must undergo capacitation to become fertilization-competent. While working on mice, we recently developed a new methodology for treating sperm in vitro, which results in higher rates of fertilization and embryo development after in vi
Externí odkaz:
https://doaj.org/article/6ffc929c917e44778766d6d8e9c7d9a5
Autor:
Melanie Balbach, Lubna Ghanem, Sara Violante, Aye Kyaw, Ana Romarowski, Justin R. Cross, Pablo E. Visconti, Lonny R. Levin, Jochen Buck
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Mammalian sperm require sufficient energy to support motility and capacitation for successful fertilization. Previous studies cataloging the changes to metabolism in sperm explored ejaculated human sperm or dormant mouse sperm surgically extracted fr
Externí odkaz:
https://doaj.org/article/bf9504cd7458481db05ef83880ae9942
Autor:
Weiwei Xu, M.M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S.V.P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112529- (2023)
Summary: Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an extranuclear AR in β cells to amplify glucagon-like peptide
Externí odkaz:
https://doaj.org/article/557572b83b5a4a7ca84c9f23c0810f39
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Targeted disruption of the soluble adenylyl cyclase (ADCY10; sAC) gene results in male-specific sterility without affecting spermatogenesis, mating behavior, or spermatozoa morphology and count; however, it dramatically impairs sperm motility and pre
Externí odkaz:
https://doaj.org/article/75032bd9c85b4addbd1c626742696f81
Autor:
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/4e985b67c0f441afacd084154e3cbd87