Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lonnie P Swift"'
Autor:
Lonnie P. Swift, B. Christoffer Lagerholm, Lucy R. Henderson, Malitha Ratnaweera, Hannah T. Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D. Ulrich, Joseph A. Newman, Christopher J. Schofield, Peter J. McHugh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract DNA double-strand breaks (DSBs), such as those produced by radiation and radiomimetics, are amongst the most toxic forms of cellular damage, in part because they involve extensive oxidative modifications at the break termini. Prior to comple
Externí odkaz:
https://doaj.org/article/cd10c307980d47f8a16e6289838eff95
Autor:
Lonnie P. Swift, B. Christoffer Lagerholm, Hannah T. Baddock, Malitha Ratnaweera, Blanka Sengerova, Sook Lee, Helle D. Ulrich, Christian Renz, Dominic Waithe, Christopher J. Schofield, Peter J. McHugh
DNA breaks, in particular double-strand breaks (DSBs), produced by radiation and radiomimetic agents are amongst the most toxic forms of DNA damage, in part because they are associated with extensive oxidative chemical modification at the break termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d08948fe4020d622be3a60633daa49d6
https://doi.org/10.1101/2022.07.21.500940
https://doi.org/10.1101/2022.07.21.500940
Autor:
Hannah T Baddock, Sanja Brolih, Yuliana Yosaatmadja, Malitha Ratnaweera, Marcin Bielinski, Lonnie P Swift, Abimael Cruz-Migoni, Haitian Fan, Jeremy R Keown, Alexander P Walker, Garrett M Morris, Jonathan M Grimes, Ervin Fodor, Christopher J Schofield, Opher Gileadi, Peter J McHugh
Publikováno v:
Nucleic acids research. 50(3)
The SARS-CoV-2 coronavirus is the causal agent of the current global pandemic. SARS-CoV-2 belongs to an order, Nidovirales, with very large RNA genomes. It is proposed that the fidelity of coronavirus (CoV) genome replication is aided by an RNA nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2c066755ee5b2308afcd92c96174c2
https://pubmed.ncbi.nlm.nih.gov/35037045
https://pubmed.ncbi.nlm.nih.gov/35037045
Autor:
Abimael Cruz-Migoni, Sanja Brolih, Peter J. McHugh, Marcin Bielinski, Opher Gileadi, Malitha Ratnaweera, Hannah T Baddock, Garrett M. Morris, Lonnie P. Swift, Yuliana Yosaatmadja, Christopher J. Schofield
The SARS-CoV-2 coronavirus (CoV) causes COVID-19, a current global pandemic. SARS-CoV-2 belongs to an order of Nidovirales with very large RNA genomes. It is proposed that the fidelity of CoV genome replication is aided by an RNA nuclease complex, fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b212d49f0dd77b66c80c4debb0646b82
https://doi.org/10.1101/2020.08.13.248211
https://doi.org/10.1101/2020.08.13.248211
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2119
DNA interstrand cross-links (ICLs) are an extremely toxic form of DNA damage that cells experience upon exposure to natural metabolites. Moreover, ICLs are cytotoxic lesions produced by a range of clinically important anticancer agents. Therefore, im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db2d8f4da892bf7957a0c29af474872f
https://pubmed.ncbi.nlm.nih.gov/31989516
https://pubmed.ncbi.nlm.nih.gov/31989516
Publikováno v:
Methods in Molecular Biology ISBN: 9781071603222
DNA interstrand cross-links (ICLs) are an extremely toxic form of DNA damage that cells experience upon exposure to natural metabolites. Moreover, ICLs are cytotoxic lesions produced by a range of clinically important anticancer agents. Therefore, im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2361560bf8cccaa3e5bd2c45e61df88
https://doi.org/10.1007/978-1-0716-0323-9_7
https://doi.org/10.1007/978-1-0716-0323-9_7
Autor:
Robert A. Forrest, Ada Rephaeli, Don R. Phillips, Lonnie P. Swift, Abraham Nudelman, Suzanne M. Cutts, Benny J. Evison
Publikováno v:
Cancer Chemotherapy and Pharmacology. 71:809-816
Epirubicin was developed as a semi-synthetic anthracycline derivative to circumvent the cardiotoxic limitations associated with the use of doxorubicin in the clinic. Anthracycline compounds have been demonstrated to form covalent drug-DNA adducts uti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8363e760f40dc41602dc93b60e019e15
https://doi.org/10.1007/s00280-012-2049-x
https://doi.org/10.1007/s00280-012-2049-x
Autor:
Peter J. McHugh, Stephanie B Hatch, Ricky A. Sharma, Lonnie P. Swift, Runjan Chetty, Mark R. Middleton, Tom P MacGregor, Richard S. Gillies, Timothy C. Humphrey
e13587 Background: Oxaliplatin is first-line chemotherapy for colorectal, gastric, and esophageal cancers. Aim was to identify key determinants of oxaliplatin sensitivity and optimise these biomarkers to select patients for chemotherapy. Methods: Hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23dc722514e2ff93f647eec257af180c
https://ora.ox.ac.uk/objects/uuid:5a7aec24-ccf2-4680-9add-71ceb493a778
https://ora.ox.ac.uk/objects/uuid:5a7aec24-ccf2-4680-9add-71ceb493a778
Autor:
Anderson T. Wang, Jacqueline H. Enzlin, Lonnie P. Swift, N.A. Burgess-Brown, Opher Gileadi, Peter J. McHugh, Blanka Sengerová, Janet M. Hartley, John A. Hartley, Konstantinos Kiakos, Christopher J. Schofield, Emma Cattell, Takabumi Inagawa
Publikováno v:
Genes & Development. 25:1859-1870
One of the major DNA interstrand cross-link (ICL) repair pathways in mammalian cells is coupled to replication, but the mechanistic roles of the critical factors involved remain largely elusive. Here, we show that purified human SNM1A (hSNM1A), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87158faf132da5bdc18a4529e5eb96a
https://doi.org/10.1101/gad.15699211
https://doi.org/10.1101/gad.15699211
Autor:
Rebecca A. Bilardi, Don R. Phillips, Robert T. C. Brownlee, Lonnie P. Swift, Andrew James. Box, Suzanne M. Cutts, Ken-ichi Kimura, Damian M. Spencer
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 10:70-77
Barminomycin is a member of the anthracycline class of anticancer agents and was originally discovered as a pink/red complex with DNA and RNA and named SN-07. The chromophore was subsequently separated from the nucleic acids by nuclease digestion and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128f52cdeaf5700f0f32f767c2f84efb
https://doi.org/10.2174/1871520611009010070
https://doi.org/10.2174/1871520611009010070