Zobrazeno 1 - 10
of 385
pro vyhledávání: '"Lonnie D. Shea"'
Autor:
Usha Nekanti, Pooja S. Sakthivel, Atena Zahedi, Dana A. Creasman, Rebecca A. Nishi, Courtney M. Dumont, Katja M. Piltti, Glenn L. Guardamondo, Norbert Hernandez, Xingyuan Chen, Hui Song, Xiaoxiao Lin, Joshua Martinez, Lillian On, Anita Lakatos, Kiran Pawar, Brian T. David, Zhiling Guo, Stephanie K. Seidlits, Xiangmin Xu, Lonnie D. Shea, Brian J. Cummings, Aileen J. Anderson
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-20 (2024)
Abstract Regeneration in the injured spinal cord is limited by physical and chemical barriers. Acute implantation of a multichannel poly(lactide-co-glycolide) (PLG) bridge mechanically stabilizes the injury, modulates inflammation, and provides a per
Externí odkaz:
https://doaj.org/article/a83ff1b397fa4089b91e5e42b4e4bde0
Autor:
Ravi M. Raghani Ph.D., Russell R. Urie Ph.D., Jeffrey A. Ma, Guillermo Escalona, Ian A. Schrack, Katarina M. DiLillo, Pridvi Kandagatla M.D., Joseph T. Decker Ph.D., Aaron H. Morris Ph.D., Kelly B. Arnold Ph.D., Jacqueline S. Jeruss M.D., Ph.D., Lonnie D. Shea Ph.D.
Publikováno v:
ImmunoMedicine, Vol 4, Iss 1, Pp n/a-n/a (2024)
Abstract Antibodies to programmed cell death protein 1 (anti‐PD‐1) have become a promising immunotherapy for triple negative breast cancer (TNBC), blocking PD‐L1 signaling from pro‐tumor cells through T cell PD‐1 receptor binding. Neverthel
Externí odkaz:
https://doaj.org/article/ade354aec4774e21aec8440151b31a5f
Autor:
Shankar Subramaniam, Metin Akay, Mark A. Anastasio, Vasudev Bailey, David Boas, Paolo Bonato, Ashutosh Chilkoti, Jennifer R. Cochran, Vicki Colvin, Tejal A. Desai, James S. Duncan, Frederick H. Epstein, Stephanie Fraley, Cecilia Giachelli, K. Jane Grande-Allen, Jordan Green, X. Edward Guo, Isaac B. Hilton, Jay D. Humphrey, Chris R Johnson, George Karniadakis, Michael R. King, Robert F. Kirsch, Sanjay Kumar, Cato T. Laurencin, Song Li, Richard L. Lieber, Nigel Lovell, Prashant Mali, Susan S. Margulies, David F. Meaney, Brenda Ogle, Bernhard Palsson, Nicholas A. Peppas, Eric J. Perreault, Rick Rabbitt, Lori A. Setton, Lonnie D. Shea, Sanjeev G. Shroff, Kirk Shung, Andreas S. Tolias, Marjolein C.H. van der Meulen, Shyni Varghese, Gordana Vunjak-Novakovic, John A. White, Raimond Winslow, Jianyi Zhang, Kun Zhang, Charles Zukoski, Michael I. Miller
Publikováno v:
IEEE Open Journal of Engineering in Medicine and Biology, Vol 5, Pp 1-13 (2024)
Over the past two decades Biomedical Engineering has emerged as a major discipline that bridges societal needs of human health care with the development of novel technologies. Every medical institution is now equipped at varying degrees of sophistica
Externí odkaz:
https://doaj.org/article/99aa19c8944b4368939a87375caa3abd
Autor:
Jing Wang, Ramon Ocadiz-Ruiz, Matthew S. Hall, Grace G. Bushnell, Sophia M. Orbach, Joseph T. Decker, Ravi M. Raghani, Yining Zhang, Aaron H. Morris, Jacqueline S. Jeruss, Lonnie D. Shea
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Biomaterial scaffolds mimicking the environment in metastatic organs can deconstruct complex signals and facilitate the study of cancer progression and metastasis. Here we report that a subcutaneous scaffold implant in mouse models of metast
Externí odkaz:
https://doaj.org/article/7ceec19b147f4e66ae168caae2f3b2a2
Autor:
Sophia M. Orbach, Christian Y. DeVaull, Elizabeth J. Bealer, Brian C. Ross, Jacqueline S. Jeruss, Lonnie D. Shea
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 1, Pp n/a-n/a (2024)
Abstract Metastatic breast cancer is often not diagnosed until secondary tumors have become macroscopically visible and millions of tumor cells have invaded distant tissues. Yet, metastasis is initiated by a cascade of events leading to formation of
Externí odkaz:
https://doaj.org/article/998da597997e490e90000c9639339a9c
Autor:
Ramon Ocadiz-Ruiz, Joseph T. Decker, Kate Griffin, Zoey M. Tan, Nishant K. Domala, Jacqueline S. Jeruss, Lonnie D. Shea
Publikováno v:
Cancers, Vol 16, Iss 4, p 796 (2024)
Metastasis is the stage at which the prognosis substantially decreases for many types of cancer. The ability of tumor cells to metastasize is dependent upon the characteristics of the tumor cells, and the conditioning of distant tissues that support
Externí odkaz:
https://doaj.org/article/9e3e0f8eb7b14bcfbf2caa6f28cd05ce
Myeloid cell reprogramming alleviates immunosuppression and promotes clearance of metastatic lesions
Autor:
Ravi M. Raghani, Jeffrey A. Ma, Yining Zhang, Sophia M. Orbach, Jing Wang, Mina Zeinali, Sunitha Nagrath, Sandeep Kakade, Qichen Xu, Joseph R. Podojil, Tushar Murthy, Adam Elhofy, Jacqueline S. Jeruss, Lonnie D. Shea
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Suppressive myeloid cells, including monocyte and neutrophil populations, play a vital role in the metastatic cascade and can inhibit the anti-tumor function of cytotoxic T-cells. Cargo-free polymeric nanoparticles (NPs) have been shown to modulate i
Externí odkaz:
https://doaj.org/article/bbd23894292c4b84ad0eca87089a47a9
Autor:
Joseph R. Podojil, Andrew C. Cogswell, Ming-Yi Chiang, Valerie Eaton, Igal Ifergan, Tobias Neef, Dan Xu, Khyati A. Meghani, Yanni Yu, Sophia M. Orbach, Tushar Murthy, Michael T. Boyne, Adam Elhofy, Lonnie D. Shea, Joshua J. Meeks, Stephen D. Miller
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cancer treatment utilizing infusion therapies to enhance the patient’s own immune response against the tumor have shown significant functionality in a small subpopulation of patients. Additionally, advances have been made in the utilization of nano
Externí odkaz:
https://doaj.org/article/ab783c6c26c045b0aab255a9140c3f66
Autor:
Kevin R. Hughes, Michael N. Saunders, Jeffrey J. Landers, Katarzyna W. Janczak, Hamza Turkistani, Laila M. Rad, Stephen D. Miller, Joseph R. Podojil, Lonnie D. Shea, Jessica J. O'Konek
Publikováno v:
Frontiers in Allergy, Vol 3 (2022)
Food allergy is a growing health concern worldwide. Current allergen-specific immunotherapy (AIT) approaches require frequent dosing over extended periods of time and may induce anaphylaxis due to allergen-effector cell interactions. A critical need
Externí odkaz:
https://doaj.org/article/3c967ed4fa074b00a0660420dcd3c09b
Autor:
Aaron H. Morris, Kevin R. Hughes, Robert S. Oakes, Michelle M. Cai, Stephen D. Miller, David N. Irani, Lonnie D. Shea
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Monitoring changes in immune phenotype during the progression of multiple sclerosis can provide insight into disease progression and inform treatment. Here the authors develop engineered biomaterial-based immunological niches for easy access to innat
Externí odkaz:
https://doaj.org/article/48cb7a477ac048fcac336e5030785778