Zobrazeno 1 - 10 of 47 pro vyhledávání: '"Lonnie, Lybarger"'
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Akademický článek
The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner.
Autor: Candida Bhagwandin, Erin L Ashbeck, Michael Whalen, Joanna Bandola-Simon, Paul A Roche, Adam Szajman, Sarah Mai Truong, Betsy C Wertheim, Yann C Klimentidis, Satoshi Ishido, Benjamin J Renquist, Lonnie Lybarger
Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0204898 (2018)
Type 2 diabetes is typified by insulin-resistance in adipose tissue, skeletal muscle, and liver, leading to chronic hyperglycemia. Additionally, obesity and type 2 diabetes are characterized by chronic low-grade inflammation. Membrane-associated RING
Externí odkaz: https://doaj.org/article/f466187204d94183a09002d74ae3f73a
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3
The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner
Autor: Benjamin J. Renquist, Satoshi Ishido, Michael B. Whalen, Betsy C. Wertheim, Adam Szajman, Candida Bhagwandin, Joanna Bandola-Simon, Lonnie Lybarger, Erin L. Ashbeck, Paul A. Roche, Yann C. Klimentidis, Sarah Mai Truong
Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 10, p e0204898 (2018)
Type 2 diabetes is typified by insulin-resistance in adipose tissue, skeletal muscle, and liver, leading to chronic hyperglycemia. Additionally, obesity and type 2 diabetes are characterized by chronic low-grade inflammation. Membrane-associated RING
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d93575ed9802ebfb70277c369468914
http://europepmc.org/articles/PMC6200199
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4
Ubiquitin-mediated Regulation of CD86 Protein Expression by the Ubiquitin Ligase Membrane-associated RING-CH-1 (MARCH1)
Autor: Debra L. Theisen, Martin J. Deymier, Maurice Jabbour, Candida Bhagwandin, Kathleen Corcoran, Lonnie Lybarger
Publikováno v: Journal of Biological Chemistry. 286:37168-37180
The activation of naïve T cells requires antigen presentation by dendritic cells (DCs), and the process of antigen presentation is regulated over the course of DC maturation. One key aspect of this regulation is the cell surface up-regulation upon D
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c825ab2b8298579cdc8f339264a0df7e
https://doi.org/10.1074/jbc.m110.204040
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5
Distinct Functions for the Glycans of Tapasin and Heavy Chains in the Assembly of MHC Class I Molecules
Autor: Malini Raghavan, Natasha Del Cid, Syed Monem Rizvi, Lonnie Lybarger
Publikováno v: The Journal of Immunology. 186:2309-2320
Complexes of specific assembly factors and generic endoplasmic reticulum (ER) chaperones, collectively called the MHC class I peptide-loading complex (PLC), function in the folding and assembly of MHC class I molecules. The glycan-binding chaperone c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e38f1f00be2d056cfec2894a0ac1cd92
https://doi.org/10.4049/jimmunol.1002959
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7
A Single Peptide–MHC Complex Positively Selects a Diverse and Specific CD8 T Cell Repertoire
Autor: Henry W. Rohrs, Michael L. Gross, Ted H. Hansen, Janet M. Connolly, Lonnie Lybarger, Tina Primeau, Baomei Wang, Nancy B. Myers
Publikováno v: Science. 326:871-874
Goldilocks ImmunologyT cells are carefully calibrated in the thymus to react to invading pathogens and to ignore the self. This occurs through interactions between the T cell receptor and major histocompatibility complexes (MHCs) expressing self-pept
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67bb861fc1a5016e87ff6917c178c41
https://doi.org/10.1126/science.1177627
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8
Human Major Histocompatibility Complex (MHC) Class I Molecules with Disulfide Traps Secure Disease-related Antigenic Peptides and Exclude Competitor Peptides
Autor: William E. Biddison, Ted H. Hansen, Beatriz M. Carreno, Daved H. Fremont, Steven M. Truscott, Xiaoli Wang, Cortez McBerry, Janet M. Connolly, Lonnie Lybarger, John M. Martinko, Gerald P. Linette
Publikováno v: Journal of Biological Chemistry. 283:7480-7490
The ongoing discovery of disease-associated epitopes detected by CD8 T cells greatly facilitates peptide-based vaccine approaches and the construction of multimeric soluble recombinant proteins (e.g. tetramers) for isolation and enumeration of antige
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0422bd0d29a9bb899fd4667f4da8f8
https://doi.org/10.1074/jbc.m709935200
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9
Structural Engineering of pMHC Reagents for T Cell Vaccines and Diagnostics
Autor: Steven M. Truscott, Lonnie Lybarger, Daved H. Fremont, Ted H. Hansen, Janet M. Connolly, Vesselin Mitaksov
Publikováno v: Chemistry & Biology. 14:909-922
MHC class I peptide complexes (pMHC) are routinely used to enumerate T cell populations, and are currently being evaluated as vaccines to tumors and specific pathogens. Herein we describe the structures of three generations of single-chain pMHC progr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca4fe68b47fc730d5b188f9216481da
https://doi.org/10.1016/j.chembiol.2007.07.010
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10
TCRβ enhancer activation in early and late lymphoid progenitors
Autor: Lonnie Lybarger, Aaron J. Martin, Hillary H. Norris, Robert Chervenak, Deborah C. Chervenak, Hanne Andersen
Publikováno v: Cellular Immunology. 247:59-71
An earlier report from our laboratory indicates that the activation of the T cell receptor (TCR) beta enhancer (Ebeta) is not always an indicator of T lineage potential in bone marrow-resident pre-lymphocytes. In order to more precisely investigate t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd1757d65681a84c253f432892ddee9
https://doi.org/10.1016/j.cellimm.2007.04.007
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