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Akademický článek

Desipramine reverses remote memory deficits by activating calmodulin-CaMKII pathway in a UTX knockout mouse model of Kabuki syndrome

Autor: Xu Zhang, Ying Zhou, Lei Chen, Qian Zhao, Yuting Li, Shuai Wang, Weidong Li, Minggang Liu, Zhaohui Lan, Xiujuan Yang, Longyong Xu, Yifang Kuang, Tatsuo Suzuki, Katsuhiko Tabuchi, Eiki Takahashi, Miou Zhou, Charlie Degui Chen, Tianle Xu

Publikováno v: General Psychiatry, Vol 37, Iss 5 (2024)

Background Kabuki syndrome (KS) is a rare developmental disorder characterised by multiple congenital anomalies and intellectual disability. UTX (ubiquitously transcribed tetratricopeptide repeat, X chromosome), which encodes a histone demethylase, i

Externí odkaz: https://doaj.org/article/a919775b7fd947ab9441d13a413119b5

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Akademický článek

CRISPR/Cas9 screen uncovers functional translation of cryptic lncRNA-encoded open reading frames in human cancer

Autor: Caishang Zheng, Yanjun Wei, Peng Zhang, Longyong Xu, Zhenzhen Zhang, Kangyu Lin, Jiakai Hou, Xiangdong Lv, Yao Ding, Yulun Chiu, Antrix Jain, Nelufa Islam, Anna Malovannaya, Yun Wu, Feng Ding, Han Xu, Ming Sun, Xi Chen, Yiwen Chen

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)

Emerging evidence suggests that cryptic translation within long noncoding RNAs (lncRNAs) may produce novel proteins with important developmental/physiological functions. However, the role of this cryptic translation in complex diseases (e.g., cancer)

Externí odkaz: https://doaj.org/article/3c21a858f3124ba098252e8992e91b5c

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Akademický článek

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice

Autor: Feng Zhang, Xiong Zhao, Runmin Jiang, Yuying Wang, Xinli Wang, Yu Gu, Longyong Xu, Jing Ye, Charlie Degui Chen, Shuangping Guo, Dawei Zhang, Daqing Zhao

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Body axial patterning develops via a rostral-to-caudal sequence and relies on the temporal colinear activation of Hox genes. However, the underlying mechanism of Hox gene temporal colinear activation remains largely elusive. Here, with small-molecule

Externí odkaz: https://doaj.org/article/e21c91bdba094b7096f430eb6148f305

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Akademický článek

Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

Autor: Xia Liu, Jingjing Yu, Longyong Xu, Katharine Umphred-Wilson, Fanglue Peng, Yao Ding, Brendan M Barton, Xiangdong Lv, Michael Y Zhao, Shengyi Sun, Yuning Hong, Ling Qi, Stanley Adoro, Xi Chen

Publikováno v: eLife, Vol 10 (2021)

Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–double negative (DN) thymocytes to generate αβ T cells in the thymus. However, how these signals ensure a high-fidelity proteome and safeguard the clon

Externí odkaz: https://doaj.org/article/a0882b95451b420da0b3daebf835253f

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Akademický článek

Endoplasmic Reticulum Stress in Bone Metastases

Autor: Longyong Xu, Weijie Zhang, Xiang H.-F. Zhang, Xi Chen

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Metastases—the spreading of cancer cells from primary tumors to distant organs, including bone—is often incurable and is the major cause of morbidity in cancer patients. Understanding how cancer cells acquire the ability to colonize to bone and b

Externí odkaz: https://doaj.org/article/17bac17492ac4746ae30844c731b79ce

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Akademický článek

Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway

Autor: Xuemei Chen, Shuai Wang, Ying Zhou, Yanfei Han, Shengtian Li, Qing Xu, Longyong Xu, Ziqi Zhu, Youming Deng, Lu Yu, Lulu Song, Adele Pin Chen, Juan Song, Eiki Takahashi, Guang He, Lin He, Weidong Li, Charlie Degui Chen

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Mutations in PHF8 gene are genetically associated with X-linked mental retardation. Here, Chen et al. show that Phf8 KO mouse have cognitive and synaptic plasticity impairment, and pharmacological inhibition of mTOR signaling can partially alleviate

Externí odkaz: https://doaj.org/article/2ef75b4f01b048c09a3f547f5a48ff9a

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