Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Longquan Quan"'
1
Akademický článek
Macrophage elastase derived from adventitial macrophages modulates aortic remodeling
Autor: Yajie Chen, Xiawen Yang, Shuji Kitajima, Longquan Quan, Yao Wang, Maobi Zhu, Enqi Liu, Liangxue Lai, Haizhao Yan, Jianglin Fan
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2023)
Abdominal aortic aneurysm (AAA) is pathologically characterized by intimal atherosclerosis, disruption and attenuation of the elastic media, and adventitial inflammatory infiltrates. Although all these pathological events are possibly involved in the
Externí odkaz: https://doaj.org/article/ce5846235ef24baf8c5aeb1d3a5c0869
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2
Akademický článek
ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems
Autor: Jingke Xie, Xingyun Huang, Xia Wang, Shixue Gou, Yanhui Liang, Fangbing Chen, Nan Li, Zhen Ouyang, Quanjun Zhang, Weikai Ge, Qin Jin, Hui Shi, Zhenpeng Zhuang, Xiaozhu Zhao, Meng Lian, Jiaowei Wang, Yinghua Ye, Longquan Quan, Han Wu, Kepin Wang, Liangxue Lai
Publikováno v: BMC Biology, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Many favorable traits of crops and livestock and human genetic diseases arise from multiple single nucleotide polymorphisms or multiple point mutations with heterogeneous base substitutions at the same locus. Current cytosine or a
Externí odkaz: https://doaj.org/article/5974bfd9c0c64e52a24cfd1869de793b
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3
Akademický článek
Efficient base editing for multiple genes and loci in pigs using base editors
Autor: Jingke Xie, Weikai Ge, Nan Li, Qishuai Liu, Fangbing Chen, Xiaoyu Yang, Xingyun Huang, Zhen Ouyang, Quanjun Zhang, Yu Zhao, Zhaoming Liu, Shixue Gou, Han Wu, Chengdan Lai, Nana Fan, Qin Jin, Hui Shi, Yanhui Liang, Ting Lan, Longquan Quan, Xiaoping Li, Kepin Wang, Liangxue Lai
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Base editors can efficiently produce single nucleotide alterations without requiring a double-strand break. Here the authors show base editing at multiple sites simultaneously in pigs.
Externí odkaz: https://doaj.org/article/9abc3946a2d240f685ea0ef9c7de72aa
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4
Akademický článek
Establishment of a rabbit Oct4 promoter-based EGFP reporter system.
Autor: Longquan Quan, Yongqiang Chen, Jun Song, Quanmei Yan, Quanjun Zhang, Sisi Lai, Nana Fan, Jige Xin, Qingjian Zou, Liangxue Lai
Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109728 (2014)
Rabbits are commonly used as laboratory animal models to investigate human diseases and phylogenetic development. However, pluripotent stem cells that contribute to germline transmission have yet to be established in rabbits. The transcription factor
Externí odkaz: https://doaj.org/article/1bac664d7ae24dc3853567e510305067
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5
Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression
Autor: Qin, Jin, Xiaoyu, Yang, Shixue, Gou, Xiaoyi, Liu, Zhenpeng, Zhuang, Yanhui, Liang, Hui, Shi, Jiayuan, Huang, Han, Wu, Yu, Zhao, Zhen, Ouyang, Quanjun, Zhang, Zhaoming, Liu, Fangbing, Chen, Weikai, Ge, Jingke, Xie, Nan, Li, Chengdan, Lai, Xiaozhu, Zhao, Jiaowei, Wang, Meng, Lian, Lei, Li, Longquan, Quan, Yinghua, Ye, Liangxue, Lai, Kepin, Wang
Publikováno v: Science China Life Sciences. 65:2269-2286
Inducible expression systems are indispensable for precise regulation and in-depth analysis of biological process. Binary Tet-On system has been widely employed to regulate transgenic expression by doxycycline. Previous pig models with tetracycline r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23bad6409f86f6101ca13e0187b430c7
https://doi.org/10.1007/s11427-021-2088-1
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6
Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses
Autor: Lei Xiao, Quanjun Zhang, Zhenpeng Zhuang, Liangxue Lai, Han Wu, Meng Lian, Yihui Chen, Yu Zhao, Qin Jin, Zhaoming Liu, Yingying Li, Zhen Ouyang, Longquan Quan, Lei Li, Yinghua Ye, Yuan Liao, Kepin Wang, Guangxun Meng, Lei Shi, Wenjing Li, Hai Wang, Weikai Ge
Publikováno v: The Journal of Immunology. 205:2532-2544
The NLRP3 inflammasome is associated with a variety of human diseases, including cryopyrin-associated periodic syndrome (CAPS). CAPS is a dominantly inherited disease with NLRP3 missense mutations. Currently, most studies on the NLRP3-inflammasome ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773bfa081eaf0b0857d9f83dbb6c7ea3
https://doi.org/10.4049/jimmunol.1901468
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7
Efficient base editing for multiple genes and loci in pigs using base editors
Autor: Qin Jin, Xiaoping Li, Yu Zhao, Shixue Gou, Longquan Quan, Jingke Xie, Hui Shi, Chengdan Lai, Xiaoyu Yang, Zhen Ouyang, Liangxue Lai, Nan Li, Kepin Wang, Xingyun Huang, Qishuai Liu, Ting Lan, Weikai Ge, Yanhui Liang, Nana Fan, Quanjun Zhang, Han Wu, Fangbing Chen, Zhaoming Liu
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Cytosine base editors (CBEs) enable programmable C-to-T conversion without DNA double-stranded breaks and homology-directed repair in a variety of organisms, which exhibit great potential for agricultural and biomedical applications. However, all rep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9872ffb280443a12fe7344cbde3d1b32
https://doaj.org/article/9abc3946a2d240f685ea0ef9c7de72aa
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9
ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems
Autor: Zhen Ouyang, Longquan Quan, Hui Shi, Nan Li, Xia Wang, Z. Zhuang, Jiaowei Wang, Fangbing Chen, Xiaozhu Zhao, Meng Lian, Liangxue Lai, Yanhui Liang, Jingke Xie, Han Wu, Xingyun Huang, Shixue Gou, Quanjun Zhang, Qin Jin, Weikai Ge, Yinghua Ye, Kepin Wang
Publikováno v: BMC Biology
BMC Biology, Vol 18, Iss 1, Pp 1-14 (2020)
BackgroundMany favorable traits of crops and livestock and human genetic diseases arise from multiple single nucleotide polymorphisms or multiple point mutations with heterogeneous base substitutions at the same locus. Current cytosine or adenine bas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f1d512a1ad72834502d79468dc23f9
http://europepmc.org/articles/PMC7510086
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10
CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I
Autor: Quanjun Zhang, Longquan Quan, Li Li, Zhen Ouyang, Z. Zhuang, Fangbing Chen, Jingke Xie, Liangxue Lai, Weikai Ge, Xiaozhu Zhao, Nan Li, Hui Shi, Jiaowei Wang, Yinghua Ye, Xingyun Huang, Shixue Gou, Meng Lian, Yanhui Liang, Han Wu, Kepin Wang, Qin Jin
Publikováno v: Mol Ther
Patients with hereditary tyrosinemia type I (HT1) present acute and irreversible liver and kidney damage during infancy. CRISPR-Cas9-mediated gene correction during infancy may provide a promising approach to treat patients with HT1. However, all pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0aa5fe28d872bac3d8aa9302487f982
https://pubmed.ncbi.nlm.nih.gov/33221434
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