Inhibition of Erb-B2 Receptor Tyrosine Kinase 3 and Associated Regulatory Pathways Potently Impairs Malignant Peripheral Nerve Sheath Tumor Proliferation and Survival.

Autor: Black LE; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina., Longo JF; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina., Anderson JC; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama., Carroll SL; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina. Electronic address: carrolst@musc.edu.

Publikováno v: The American journal of pathology [Am J Pathol] 2023 Sep; Vol. 193 (9), pp. 1298-1318. Date of Electronic Publication: 2023 Jun 14.

LPAR1 and aberrantly expressed LPAR3 differentially promote the migration and proliferation of malignant peripheral nerve sheath tumor cells.

Autor: Doutt SW; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.; The Medical Scientist Training Program, Medical University of South Carolina, Charleston, South Carolina, USA., Longo JF; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Carroll SL; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

Publikováno v: Glia [Glia] 2023 Mar; Vol. 71 (3), pp. 742-757. Date of Electronic Publication: 2022 Nov 23.

R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.

Autor: Weber SM; Department of Pathology and Laboratory Medicine (SMW, AP, JFL, SLC), MUSC Medical Scientist Training Program (SMW), Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA.; Departments of Pathology (NMB, SNB, SLC), Pharmacology and Toxicology (SB, LSW), UAB Medical Scientist Training Program (NMB, SNB), Birmingham, USA.; The University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Brossier NM; Department of Pathology and Laboratory Medicine (SMW, AP, JFL, SLC), MUSC Medical Scientist Training Program (SMW), Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA.; Departments of Pathology (NMB, SNB, SLC), Pharmacology and Toxicology (SB, LSW), UAB Medical Scientist Training Program (NMB, SNB), Birmingham, USA.; The University of Alabama at Birmingham, Birmingham, AL, 35294, USA.; Department of Pediatrics, St. Louis Children's Hospital, St. Louis, USA., Prechtl A; Department of Pathology and Laboratory Medicine (SMW, AP, JFL, SLC), MUSC Medical Scientist Training Program (SMW), Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA.; Departments of Pathology (NMB, SNB, SLC), Pharmacology and Toxicology (SB, LSW), UAB Medical Scientist Training Program (NMB, SNB), Birmingham, USA.; The University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Barnes S; Department of Pathology and Laboratory Medicine (SMW, AP, JFL, SLC), MUSC Medical Scientist Training Program (SMW), Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA.; Departments of Pathology (NMB, SNB, SLC), Pharmacology and Toxicology (SB, LSW), UAB Medical Scientist Training Program (NMB, SNB), Birmingham, USA.; The University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Wilson LS; Department of Pathology and Laboratory Medicine (SMW, AP, JFL, SLC), MUSC Medical Scientist Training Program (SMW), Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA.; Departments of Pathology (NMB, SNB, SLC), Pharmacology and Toxicology (SB, LSW), UAB Medical Scientist Training Program (NMB, SNB), Birmingham, USA.; The University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Brosius SN; Department of Pathology and Laboratory Medicine (SMW, AP, JFL, SLC), MUSC Medical Scientist Training Program (SMW), Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA.; Departments of Pathology (NMB, SNB, SLC), Pharmacology and Toxicology (SB, LSW), UAB Medical Scientist Training Program (NMB, SNB), Birmingham, USA.; The University of Alabama at Birmingham, Birmingham, AL, 35294, USA.; Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.; Division of Child Neurology, Children's Hospital of Philadelphia, Philadelphia, USA., Longo JF; Department of Pathology and Laboratory Medicine (SMW, AP, JFL, SLC), MUSC Medical Scientist Training Program (SMW), Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA.; Departments of Pathology (NMB, SNB, SLC), Pharmacology and Toxicology (SB, LSW), UAB Medical Scientist Training Program (NMB, SNB), Birmingham, USA.; The University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Carroll SL; Department of Pathology and Laboratory Medicine (SMW, AP, JFL, SLC), MUSC Medical Scientist Training Program (SMW), Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA. carrolst@musc.edu.; Departments of Pathology (NMB, SNB, SLC), Pharmacology and Toxicology (SB, LSW), UAB Medical Scientist Training Program (NMB, SNB), Birmingham, USA. carrolst@musc.edu.; The University of Alabama at Birmingham, Birmingham, AL, 35294, USA. carrolst@musc.edu.

Publikováno v: Cell communication and signaling : CCS [Cell Commun Signal] 2021 Sep 16; Vol. 19 (1), pp. 95. Date of Electronic Publication: 2021 Sep 16.

Establishment and genomic characterization of a sporadic malignant peripheral nerve sheath tumor cell line.

Autor: Longo JF; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA., Brosius SN; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35294-0017, USA.; Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL, 35294-0017, USA.; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Znoyko I; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA., Alers VA; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA., Jenkins DP; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA., Wilson RC; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA.; Center for Genomic Medicine, Medical University of South Carolina, Charleston, SC, 29425-9080, USA., Carroll AJ; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, 35294-0017, USA., Wolff DJ; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA., Roth KA; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA., Carroll SL; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA. carrolst@musc.edu.; Center for Genomic Medicine, Medical University of South Carolina, Charleston, SC, 29425-9080, USA. carrolst@musc.edu.; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35294-0017, USA. carrolst@musc.edu.

Publikováno v: Scientific reports [Sci Rep] 2021 Mar 11; Vol. 11 (1), pp. 5690. Date of Electronic Publication: 2021 Mar 11.

Mechanisms of Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) Action in Human Neoplasia.

Autor: Black LE; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina., Longo JF; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina., Carroll SL; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina. Electronic address: carrolst@musc.edu.

Publikováno v: The American journal of pathology [Am J Pathol] 2019 Oct; Vol. 189 (10), pp. 1898-1912. Date of Electronic Publication: 2019 Jul 25.