Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Longmiao Hu"'
Autor:
Yanan Liu, Longmiao Hu, Zhengzhen Wu, Kun Yuan, Guangliang Hong, Zhengke Lian, Juanjuan Feng, Na Li, Dali Li, Jiemin Wong, Jiekai Chen, Mingyao Liu, Jiangping He, Xiufeng Pang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Immunotherapy has become established as major treatment modality for multiple types of solid tumors, including colorectal cancer. Identifying novel immunotherapeutic targets to enhance anti-tumor immunity and sensitize current immune checkpo
Externí odkaz:
https://doaj.org/article/cfd906eb22b048cdb7a03488a79f3fcd
Autor:
Juanjuan Feng, Zhengke Lian, Xinting Xia, Yue Lu, Kewen Hu, Yunpeng Zhang, Yanan Liu, Longmiao Hu, Kun Yuan, Zhenliang Sun, Xiufeng Pang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 3, Pp 1145-1163 (2023)
MEK is a canonical effector of mutant KRAS; however, MEK inhibitors fail to yield satisfactory clinical outcomes in KRAS-mutant cancers. Here, we identified mitochondrial oxidative phosphorylation (OXPHOS) induction as a profound metabolic alteration
Externí odkaz:
https://doaj.org/article/330cb01aa91d4b50ae4c436b870a5b24
Autor:
Yanan Liu, Juanjuan Feng, Kun Yuan, Zhengzhen Wu, Longmiao Hu, Yue Lu, Kun Li, Jiawei Guo, Jing Chen, Chengbin Ma, Xiufeng Pang
Publikováno v:
eLife, Vol 11 (2022)
Genotoxic agents remain the mainstay of cancer treatment. Unfortunately, the clinical benefits are often countered by a rapid tumor adaptive response. Here, we report that the oncoprotein B cell lymphoma 6 (BCL6) is a core component that confers soli
Externí odkaz:
https://doaj.org/article/e7c169f84800472e81c9cfc2cf641fdd
Autor:
Feng Xie, Changying Shi, Guoqing Zhu, Longmiao Hu, Jiamei Yang, Weifeng Shen, Liang Qiao, Boyi Liao
Publikováno v:
Aging (Albany NY)
The poor prognosis of hepatocellular carcinoma (HCC) is primarily attributed to its high frequency of recurrence and resistance to chemotherapy. Epithelial-to-mesenchymal transition (EMT) and the acquisition of cancer stem cells (CSCs) are the fundam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641f542b078a7adabfa8dec7fb181c7d
http://europepmc.org/articles/PMC7467378
http://europepmc.org/articles/PMC7467378
Autor:
Wannian Zhang, Xiaofei Chen, Xia Qin, Long Chen, Zhenyuan Miao, Xu Lijuan, Hui Cong, Zhenyu Cai, Hao Zhang, Chunlin Zhuang, Longmiao Hu
Publikováno v:
Journal of Medicinal Chemistry. 62:6665-6681
Necroptosis, a form of programmed cell death, plays a critical role in various diseases, including inflammatory, infectious, and degenerative diseases. We previously identified N-(7-cyano-6-(4-fluo...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3de275c151f92aab8642cd797ea92a81
https://doi.org/10.1021/acs.jmedchem.9b00611
https://doi.org/10.1021/acs.jmedchem.9b00611
Autor:
Chunlin Zhuang, Ye-xiong Tan, Jianqiang Yu, Longmiao Hu, Shen-nan Shi, Xiaofei Chen, Siriporn Jitkaew, Xia Qin, Xiufeng Pang, Zhenyu Cai, Hong-yang Wang, Wen Zhang
Publikováno v:
Biochemical pharmacology. 177
Necroptosis is a form of programmed, caspase-independent cell death that is involved in various pathologic disorders such as ischemia/reperfusion injury, acute kidney injury and inflammatory bowel diseases. Identification of necroptosis inhibitors ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4352ab7374367dc479769eec530e102c
https://pubmed.ncbi.nlm.nih.gov/32247850
https://pubmed.ncbi.nlm.nih.gov/32247850
Autor:
Hong-yang Wang, Yibin Ren, Yifeng Chai, Chunlin Zhuang, Jing Fu, Zheng-gang Liu, Haibing Zhang, Miao Zhenyuan, Xiaofei Chen, Xia Qin, Hao Zhang, Zhenyu Cai, Longmiao Hu
Publikováno v:
Br J Pharmacol
Background and purpose Necroptosis is a form of programmed, caspase-independent, cell death, mediated by receptor-interacting protein kinases, RIPK1 and RIPK3, and the mixed lineage kinase domain-like (MLKL). Necroptosis contributes to the pathophysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f67f0a6fb55935ef90b785c4bbb9b46
https://pubmed.ncbi.nlm.nih.gov/30825190
https://pubmed.ncbi.nlm.nih.gov/30825190