Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Longjia Yan"'
1
Akademický článek
Design, Synthesis, and Anti-Leukemic Evaluation of a Series of Dianilinopyrimidines by Regulating the Ras/Raf/MEK/ERK and STAT3/c-Myc Pathways
Autor: Chaoyan Wang, Bo Wang, Yu Mou, Xiang Liu, Qiqing Chen, Weidong Pu, Qing Rao, Chunlin Wang, Jingrui Song, Yubing Huang, Longjia Yan, Lei Huang, Yanmei Li
Publikováno v: Molecules, Vol 29, Iss 7, p 1597 (2024)
Although the long-term survival rate for leukemia has made significant progress over the years with the development of chemotherapeutics, patients still suffer from relapse, leading to an unsatisfactory outcome. To discover the new effective anti-leu
Externí odkaz: https://doaj.org/article/86470e5c56dd42f5aad32a864188d593
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2
Akademický článek
Design, synthesis and biological evaluation of a series of dianilinopyrimidines as EGFR inhibitors
Autor: Longjia Yan, Qin Wang, Li Liu, Yi Le
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 832-843 (2022)
This paper described our efforts to develop dianilinopyrimidines as novel EGFR inhibitors. All the target compounds were tested for inhibitory effects against wild type EGFR (EGFRwt) and three tumour cells, including A549, PC-3, and HepG2. Some of th
Externí odkaz: https://doaj.org/article/3ea05789c26d4e8398a323105a2dc5df
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3
Akademický článek
Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors
Autor: Yaqing Zuo, Rongrong Li, Yan Zhang, Guochen Bao, Yi Le, Longjia Yan
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2742-2754 (2022)
A new series of 5-trifluoromethylpyrimidine derivatives were designed and synthesised as EGFR inhibitors. Three tumour cells A549, MCF-7, PC-3 and EGFR kinase were employed to evaluate their biological activities. The results were shown that most of
Externí odkaz: https://doaj.org/article/73071dcf92cd4afd9bd84c30769639ef
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4
Akademický článek
Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells
Autor: Yan Zhang, Qin Wang, Luolan Li, Yi Le, Li Liu, Jing Yang, Yongliang Li, Guochen Bao, Longjia Yan
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1205-1216 (2021)
In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and studied the preliminary structure-activity relationship for antiproliferative activities. All target compounds performed significantly inhibitory effects agains
Externí odkaz: https://doaj.org/article/43ad163bbe804b18b2ac20efeb3d997a
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5
Akademický článek
Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment
Autor: Yi Le, Yiyuan Gan, Yihong Fu, Jiamin Liu, Wen Li, Xue Zou, Zhixu Zhou, Zhenchao Wang, Guiping Ouyang, Longjia Yan
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 555-564 (2020)
In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and three human cancer cell lines in
Externí odkaz: https://doaj.org/article/ab044beaca364dd6aee5780005cddd1b
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6
A new phenothiazine-based fluorescent probe for detection of hydrazine with naked-eye color change properties
Autor: Dan Li, Li Liu, Yi Le, Qin Wang, Nian Rao, Longjia Yan, Yan Zhang
Publikováno v: Chemical Papers. 76:267-275
A new fluorescent probe (PAC) based on phenothiazine was designed and synthesized for the detection of hydrazine (N2H4), which uses methyl cyanoacetate as the recognition group and phenothiazine as the fluorescent chromophore. The Stoke shift of prob
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad5b8fbf843de8b3d95768c8067d9548
https://doi.org/10.1007/s11696-021-01859-6
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7
Discovery of 4-nitro-3-phenylisoxazole derivatives as potent antibacterial agents derived from the studies of [3 + 2] cycloaddition
Autor: Yan Zhang, Zhiwu Long, Longjia Yan, Li Liu, Lan Yang, Yi Le
Publikováno v: RSC advances. 12(39)
Thirty-five compounds with phenylisoxazole scaffold were synthesized via [3+2] cycloaddition. After being evaluated against Xoo, Psa and Xac, 4-nitro-3-phenylisoxazole derivatives were found well antibacterial activities.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6202a8646688ca4c5fb3c9da520e2225
https://pubmed.ncbi.nlm.nih.gov/36199305
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8
Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells
Autor: Jing Yang, Qin Wang, Yan Zhang, Longjia Yan, Yongliang Li, Luolan Li, Guochen Bao, Li Liu, Yi Le
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1205-1216 (2021)
In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and studied the preliminary structure-activity relationship for antiproliferative activities. All target compounds performed significantly inhibitory effects agains
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c25df948eb63daccedc68f44eb34e0
https://doi.org/10.1080/14756366.2021.1933466
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9
Synthesis, crystal structure, DFT calculation and biological activity of 3-((4-chloro-6-((4-morpholinophenyl)amino)-1,3,5-triazin-2-yl)amino)-N-methylthiophene-2-carboxamide
Autor: Nian Rao, Yuyu Ding, Lan Yang, Yue Zhou, Yi Le, Longjia Yan, Li Liu
1,3,5-Triazine derivatives have a wide range of biological and pharmaceutical activities. According to the extensive application of this compounds, 3-(4-chloro-6-(4-morpholinophenyl)amino)-1,3,5-triazin-2-yl)amino)-N-methylthiophene-2-formamide was s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28791b1f2f79dd970aabc8c537962466
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