Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Longhu, Zhou"'
Autor:
Longhu Zhou, Hongwang Zhang, Chengwei Li, Coralie De Schutter, Ozkan Sari, Seema Mengshetti, Shaoman Zhou, Mahesh Kasthuri, Steven J. Coats, Raymond F. Schinazi, Franck Amblard
Publikováno v:
ACS Omega, Vol 7, Iss 1, Pp 1452-1461 (2021)
Externí odkaz:
https://doaj.org/article/e014eeef2887439f89555878649fce6a
Autor:
Franck Amblard, Julia C. LeCher, Ramyani De, Shu Ling Goh, Chengwei Li, Mahesh Kasthuri, Nicolas Biteau, Longhu Zhou, Zahira Tber, Jessica Downs-Bowen, Keivan Zandi, Raymond F. Schinazi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1144 (2022)
Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molnupiravir, an ester prodrug form of N4-hydroxycytidine (NHC), was re
Externí odkaz:
https://doaj.org/article/5b28f39250b449959a136cc3c1d06f07
Autor:
Joseph A Hollenbaugh, Jadd Shelton, Sijia Tao, Sheida Amiralaei, Peng Liu, Xiao Lu, Russell W Goetze, Longhu Zhou, James H Nettles, Raymond F Schinazi, Baek Kim
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169052 (2017)
SAMHD1 hydrolyzes 2'-deoxynucleoside-5'-triphosphates (dNTPs) into 2'-deoxynucleosides and inorganic triphosphate products. In this paper, we evaluated the impact of 2' sugar moiety substitution for different nucleotides on being substrates for SAMHD
Externí odkaz:
https://doaj.org/article/7585f5c3a1dc4457859860a505db1ff0
Autor:
Franck, Amblard, Julia C, LeCher, Ramyani, De, Shu Ling, Goh, Chengwei, Li, Mahesh, Kasthuri, Nicolas, Biteau, Longhu, Zhou, Zahira, Tber, Jessica, Downs-Bowen, Keivan, Zandi, Raymond F, Schinazi
Publikováno v:
Pharmaceuticals (Basel, Switzerland). 15(9)
Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molnupiravir, an ester prodrug form of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63af522e05432f7cb7d7994e33bcc0d6
https://pubmed.ncbi.nlm.nih.gov/36145365
https://pubmed.ncbi.nlm.nih.gov/36145365
Autor:
Rebeca Rocha, Longhu Zhou, Marília Zaluar P. Guimarães, Christina Gavegnano, Juliana L. Del Sarto, Leda Bassit, Franck Amblard, Vivian Vasconcelos Costa, Bruno V. S. Valiate, Isabella G. Olmo, Carolina da S. G. Pedrosa, Mauro M. Teixeira, Fabiola M. Ribeiro, Stevens K. Rehen, Bryan Cox, Celso Martins Queiroz-Junior, Raymond F. Schinazi
Publikováno v:
Antiviral research. 180
Zika virus (ZIKV) has gained a lot of attention in the past few years due to its rapid spread worldwide and its close association to severe neurological outcomes, such as microcephaly and Guillain-Barre syndrome. In this study, the in vitro and in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f443720eb970fd2c9d23d24ce9d3c4d
https://pubmed.ncbi.nlm.nih.gov/32574688
https://pubmed.ncbi.nlm.nih.gov/32574688
Autor:
Sijia, Tao, Longhu, Zhou, Hongwang, Zhang, Shaoman, Zhou, Sheida, Amiralaei, Jadd, Shelton, Maryam, Ehteshami, Yong, Jiang, Franck, Amblard, Steven J, Coats, Raymond F, Schinazi
Publikováno v:
Nucleosides Nucleotides Nucleic Acids
β-D-2’-C-Methyl-2,6-diaminopurine ribonucleoside (2’-C-Me-DAPN) phosphoramidate prodrug (DAPN-PD) is a selective hepatitis C virus inhibitor that is metabolized intracellularly into two active metabolites: 2’-C-Methyl-DAPN triphosphate (2’-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d517a184786af63da1a6f89e46fc4ab
https://pubmed.ncbi.nlm.nih.gov/31595843
https://pubmed.ncbi.nlm.nih.gov/31595843
Autor:
Raymond F. Schinazi, Leda Bassit, Olivia Ollinger Russell, Keivan Zandi, Sarah Amichai, Yong Jiang, Longhu Zhou, Franck Amblard, Seema Mengshetti, Sijia Tao
Yellow fever virus (YFV) is a human Flavivirus reemerging in parts of the world. While a vaccine is available, large outbreaks have recently occurred in Brazil and certain African countries. Development of an effective antiviral against YFV is crucia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f62a17aae15a6b6077f7e639c495fb
https://europepmc.org/articles/PMC6709485/
https://europepmc.org/articles/PMC6709485/
Autor:
Hongwang Zhang, Franck Amblard, Keivan Zandi, Raymond F. Schinazi, Sarah Amichai, Bryan Cox, Longhu Zhou
Publikováno v:
Bioorg Med Chem Lett
Exploration of the chemical space of known influenza polymerase PB2 inhibitor Pimodivir, was performed by our group. We synthesized and identified compounds 16a and 16b, two novel thienopyrimidine derivatives displaying anti-influenza A activity in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af8d501a5ce89b22af588dc47bad0fb
https://pubmed.ncbi.nlm.nih.gov/31493987
https://pubmed.ncbi.nlm.nih.gov/31493987
Autor:
Mauro Martins Teixeira, Longhu Zhou, Ingredy Passos, Leda Bassit, Vivian Vasconcelos Costa, Pouya Hassandarvish, Ehsan Moghaddam, Andrew Yueh, Gisele Olinto Libanio Rodrigues, Raymond F. Schinazi, Bryan Cox, Franck Amblard, Sazaly AbuBakar, Keivan Zandi, James J. Kohler
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
Dengue virus (DENV) and Japanese encephalitis virus (JEV) are important arthropod-borne viruses from the Flaviviridae family. DENV is a global public health problem with significant social and economic impacts, especially in tropical and subtropical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a3cca903f29cc71691242b17c7fdc4
https://doi.org/10.1128/aac.00397-19
https://doi.org/10.1128/aac.00397-19
Autor:
Tamara R. McBrayer, Biing Y. Lin, Kiran Verma, Ozkan Sari, Olivia Ollinger Russell, Judy Pattassery, Yong Jiang, Maria Luz G. Pascual, Steven J. Coats, Seema Mengshetti, Leda Bassit, Jong Hyun Cho, Reuben Ovadia, Sijia Tao, Sam Lee, Mahesh Kasthuri, Robert A. Domaoal, Tony Whitaker, Coralie De Schutter, Raymond F. Schinazi, Longhu Zhou, Lothar Uher, Hongwang Zhang, Maryam Ehteshami, Franck Amblard
Publikováno v:
J Med Chem
Hepatitis C virus (HCV) nucleoside inhibitors display pan-genotypic activity, a high barrier to the selection of resistant virus, and are some of the most potent direct-acting agents with durable sustained virologic response in humans. Herein, we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4794025b05590c85d7b550e01a145ca5
https://pubmed.ncbi.nlm.nih.gov/30653317
https://pubmed.ncbi.nlm.nih.gov/30653317