Precision proteoform design for 4R tau isoform selective templated aggregation.

Autor: Longhini AP; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106.; Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106., DuBose A; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA 93106., Lobo S; Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106., Vijayan V; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA 93106., Bai Y; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106.; Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106.; Photothermal Spectroscopy Corp., Santa Barbara, CA 93101., Rivera EK; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106.; Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106., Sala-Jarque J; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106.; Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106., Nikitina A; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106.; Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106., Carrettiero DC; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106.; Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106.; Center for Natural and Human Sciences, Federal University of ABC, São Bernardo do Campo, São Paulo 09600-000, Brazil., Unger MT; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106.; Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106., Sclafani OR; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106.; Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106., Fu V; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106.; Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106., Beckett ER; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106.; Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106., Vigers M; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA 93106., Buée L; University of Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition Lille F-59000, France.; Laboratoire d'Excellence Development of Innovative Strategies for a Transdisciplinary Approach to Alzheimer's Disease, Alzheimer & Tauopathies Team, Lille F-59000, France., Landrieu I; Center National de la Recherche Scientifique Équipe de Recherche 9002-Integrative Structural Biology, Lille F-59000, France.; University of Lille, Inserm, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1167-Risk Factors and Molecular Determinants of Aging-Related Diseases Lille F-59000, France., Shell S; Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106., Shea JE; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA 93106.; Department of Physics, University of California Santa Barbara, Santa Barbara, CA 93106., Han S; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA 93106.; Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106., Kosik KS; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106.; Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Apr 09; Vol. 121 (15), pp. e2320456121. Date of Electronic Publication: 2024 Apr 03.

Tau P301L mutation promotes core 4R tauopathy fibril fold through near-surface water structuring and conformational rearrangement.

Autor: Vigers MP, Lobo S, Najafi S, Dubose A, Tsay K, Ganguly P, Longhini AP, Jin Y, Buratto SK, Kosik KS, Shell MS, Shea JE, Han S

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 28. Date of Electronic Publication: 2023 Nov 28.

Hepatitis B Virus Epsilon (ε) RNA Element: Dynamic Regulator of Viral Replication and Attractive Therapeutic Target.

Autor: Olenginski LT; Center for Biomolecular Structure and Organization, Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.; Department of Biochemistry, University of Colorado, Boulder, CO 80309, USA., Attionu SK; Center for Biomolecular Structure and Organization, Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA., Henninger EN; Center for Biomolecular Structure and Organization, Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA., LeBlanc RM; Center for Biomolecular Structure and Organization, Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA., Longhini AP; Center for Biomolecular Structure and Organization, Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.; Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.; Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA., Dayie TK; Center for Biomolecular Structure and Organization, Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.

Publikováno v: Viruses [Viruses] 2023 Sep 12; Vol. 15 (9). Date of Electronic Publication: 2023 Sep 12.

Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate.

Autor: Carrettiero DC; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA.; Center for Natural and Human Sciences, Federal University of ABC, São Bernardo do Campo, SP, Brazil., Almeida MC; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA.; Center for Natural and Human Sciences, Federal University of ABC, São Bernardo do Campo, SP, Brazil., Longhini AP; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA., Rauch JN; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA., Han D; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA., Zhang X; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA., Najafi S; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA., Gestwicki JE; Institute for Neurodegenerative Disease, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Kosik KS; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA. kosik@lifesci.ucsb.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Jun 02; Vol. 13 (1), pp. 3074. Date of Electronic Publication: 2022 Jun 02.

Structural insights of the conserved "priming loop" of hepatitis B virus pre-genomic RNA.

Autor: LeBlanc RM; Basic Research Laboratory, National Cancer Institute, Frederick, MD, USA.; Vertex Pharmaceuticals, Boston, MA, USA., Kasprzak WK; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Longhini AP; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.; Department of Molecular, Cell and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA., Olenginski LT; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA., Abulwerdi F; Basic Research Laboratory, National Cancer Institute, Frederick, MD, USA., Ginocchio S; Basic Research Laboratory, National Cancer Institute, Frederick, MD, USA., Shields B; RNA Biology Laboratory, National Cancer Institute, Frederick, MD, USA., Nyman J; Basic Research Laboratory, National Cancer Institute, Frederick, MD, USA., Svirydava M; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA., Del Vecchio C; Department of Molecular Medicine, University of Padua, Padua, Italy., Ivanic J; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Schneekloth JS Jr; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA., Shapiro BA; RNA Biology Laboratory, National Cancer Institute, Frederick, MD, USA., Dayie TK; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA., Le Grice SFJ; Basic Research Laboratory, National Cancer Institute, Frederick, MD, USA.

Publikováno v: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2022; Vol. 40 (20), pp. 9761-9773. Date of Electronic Publication: 2021 Jun 22.