Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Longevity Pathway"'
Autor:
Siva A. Vanapalli, Rashmi Kamble, Aldo Jongejan, Siddhartha Gupta, Marte Molenaars, Simone Denis, Georges E. Janssens, Marton L. Toth, Bauke V. Schomakers, Rebecca L. McIntyre, Michael A. Petr, Mizanur Rahman, Morten Scheibye-Knudsen, Riekelt H. Houtkooper
Publikováno v:
McIntyre, R L, Denis, S W, Kamble, R, Molenaars, M, Petr, M, Schomakers, B V, Rahman, M, Gupta, S, Toth, M L, Vanapalli, S A, Jongejan, A, Scheibye-Knudsen, M, Houtkooper, R H & Janssens, G E 2021, ' Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevity ', Aging Cell, vol. 20, no. 8, pp. e13381 . https://doi.org/10.1111/acel.13381
Aging cell, 20(8):e13381. Wiley-Blackwell
Aging Cell
Aging cell, 20(8):e13381. Wiley-Blackwell
Aging Cell
Transcriptome‐based drug screening is emerging as a powerful tool to identify geroprotective compounds to intervene in age‐related disease. We hypothesized that, by mimicking the transcriptional signature of the highly conserved longevity interve
Publikováno v:
Evidence-Based Complementary and Alternative Medicine, Vol 2019 (2019)
Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-based Complementary and Alternative Medicine : eCAM
Aiweixin (AWX) is a traditional Uyghur medicine prescription, which has been used to treat senile diseases for a long time. We investigate whether the AWX extends the lifespan of Caenorhabditis elegans. The AWX decoction was the conventional product
Autor:
Ruofan Yu, Jun-yi Zhu, Wei Liu, Weiwei Dang, Brian M. Wasko, Haiying Liu, Lidong Qin, Luyang Sun, Zhe Han, Xiaohua Cao, Matt Kaeberlein, Emeline Crutcher, Myeong Chan Jo
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Histone acetylations are important epigenetic markers for transcriptional activation in response to metabolic changes and various stresses. Using the high-throughput SEquencing-Based Yeast replicative Lifespan screen method and the yeast knockout col
Autor:
Aldo Jongejan, Georges E. Janssens, Riekelt H. Houtkooper, Rashmi Kamble, Morten Scheibye-Knudsen, Simone Denis, Michael A. Petr, Bauke V. Schomakers, Rebecca L. McIntyre
Transcriptome-based drug screening is emerging as a powerful tool to identify geroprotective compounds to intervene in age-related disease. We hypothesized that, by mimicking the transcriptional signature of the highly conserved longevity interventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de598c1289b03e852484375697ad299a
https://doi.org/10.1101/2020.07.24.219584
https://doi.org/10.1101/2020.07.24.219584
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The entomopathogenic nematode Steinernema carpocapsae has been used for control of soil insects. However, S. carpocapse is sensitive to environmental factors, particularly temperature. We studied an S. carpocapse group that was shocked with high temp
Publikováno v:
Aging (Albany NY)
Histone deacetylase (HDAC) 1 regulates chromatin compaction and gene expression by removing acetyl groups from lysine residues within histones. HDAC1 affects a variety of processes including proliferation, development, metabolism, and cancer. Reducti
Autor:
Susan J. Broughton, Nazif Alic, Danny Filer, Abbie Rogan, Yodit Feseha, George Phillips, Guillermo Martínez Corrales, Katharina C. Wenz, Mengjia Li
Publikováno v:
Cell Reports
Cell Reports, Vol 30, Iss 6, Pp 1661-1669.e4 (2020)
Cell Reports, Vol 30, Iss 6, Pp 1661-1669.e4 (2020)
Summary Health and survival in old age can be improved by changes in gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task is to generate the pre-ribosomal RNA (rRNA). We find that reducing the levels of Pol I activity
Autor:
Nolan G. Ericson, Nathan Basisty, Vivian L. MacKay, Dao-Fu Dai, Edward J. Hsieh, Jason H. Bielas, David A. Crispin, Pabalu P. Karunadharma, Michael J. MacCoss, Ying A. Chiao, Richard P. Beyer, Peter S. Rabinovitch, Ellen Quarles
Publikováno v:
Aging Cell
Calorie restriction (CR) and rapamycin (RP) extend lifespan and improve health across model organisms. Both treatments inhibit mammalian target of rapamycin (mTOR) signaling, a conserved longevity pathway and a key regulator of protein homeostasis, y
Publikováno v:
Journal of Cellular Biochemistry. 116:242-251
MicroRNAs (miRNAs), especially evolutionarily conserved miRNAs play critical roles in regulating various biological process. However, the functions of conserved miRNAs in longevity are still largely unknown. Astragalus polysaccharide (APS) was recent
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Cell-non-autonomous signals dictate the functional state of cellular quality control systems, remodeling the ability of cells to cope with stress and maintain protein homeostasis (proteostasis). One highly regulated cell-non-autonomous switch control