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Sinteza longamida B i analoga ramnolipida i njihova fizičko-hemijska i biološka karakterizacija

Autor: Jovanović, Miloš

Publikováno v: Универзитет у Београду

Ramnolipidi su ekološki prihvatljivi biosurfaktanti koje proizvodi bakterija Pseudomonas aeruginosa. Zbog interesantnog biološkog profila i odličnih fizičko-hemijskih svojstava nalaze primenu u biotehnologiji, bioremedijaciji i medicini. Njihova

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ac39e69c40d6548da097548608f66a3f
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3720

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Proline Derived Bicyclic Derivatives through Metal Catalysed Cyclisations of Allenes: Synthesis of Longamide B, Stylisine D and their Derivatives

Autor: Jovanović, Miloš, Petković, Miloš, Jovanović, Predrag, Simić, Milena, Tasić, Gordana, Erić, Slavica, Savić, Vladimir

Publikováno v: European Journal of Organic Chemistry

Annulations of allene-substituted proline derivatives promoted by transition metals have been investigated as a general way to access bicyclic structures with a bridgehead nitrogen. Two processes, Pd- and Ag-catalysed cyclisations, have been employed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4877::4efe4d558eef057752c8cc72d71e65f6
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3481

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Efficient Synthesis of (–)-Hanishin, (–)-Longamide B, and (–)-Longamide B Methyl Ester through Piperazinone Formation from 1,2-Cyclic Sulfamidates

Autor: Zenyu Shiokawa, Koichi Fukase, Shinsuke Inuki, Yukari Fujimoto

Publikováno v: Synlett. 27:616-620

We describe a simple chiral-pool synthesis of (–)-longamide B, (–)-longamide B methyl ester, and (–)-hanishin. The key feature of the total synthesis is the formation of a piperazinone from a 1,2-cyclic sulfamidate and methyl 2-pyrrolecarboxyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ada63c34e4221ac69b7f63618dd3754f
https://doi.org/10.1055/s-0035-1560988

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Total synthesis and cytotoxic activities of longamide B, longamide B methyl ester, hanishin, and their analogues

Autor: Yu Zhang, Deng-Gao Zhao, Wei Peng, Liugang Ding, Kun Zhang, Yan-Yan Ma, Ai-Yu Zhou, Zhiyun Du

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 26:6-8

The marine alkaloids, longamide B (1), longamide B methyl ester (2), hanishin (3), and a series of non-naturally occurring analogues were synthesized in an efficient manner from inexpensive commercially available dl-aspartic acid dimethyl ester. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c1b712737cdb17b2f7b13d76700b2a
https://doi.org/10.1016/j.bmcl.2015.11.069

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Discovery of a Novel Scaffold as an Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid, Longamide B

Autor: Daisuke Yoshidome, Yukari Fujimoto, Koichi Fukase, Shinsuke Inuki, Emi Kashiwabara, Zenyu Shiokawa

Publikováno v: ChemMedChem. 11:2682-2689

Indoleamine 2,3-dioxygenase 1 (IDO1) has emerged as a key target for cancer therapy, as IDO1 plays a critical role in the capacity of tumor cells to evade the immune system. The pyrrolopiperazinone alkaloid longamide B and its derivatives were identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21252a0b0ec7ba3b6b6de5559d8f996c
https://doi.org/10.1002/cmdc.201600446

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Cover Feature: Proline Derived Bicyclic Derivatives through Metal Catalysed Cyclisations of Allenes: Synthesis of Longamide B, Stylisine D and their Derivatives (Eur. J. Org. Chem. 3/2020)

Autor: Slavica Erić, Vladimir Savic, Gordana Tasic, Milos Jovanovic, Predrag Jovanović, Milena Simic, Milos Petkovic

Publikováno v: European Journal of Organic Chemistry. 2020:268-268

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cef77c8bc65baddb0e937c94eab2ad16
https://doi.org/10.1002/ejoc.202000038

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