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Akademický článek

Synthesis and Positive Inotropic Activity of [1,2,4]Triazolo[4,3-a] Quinoxaline Derivatives Bearing Substituted Benzylpiperazine and Benzoylpiperazine Moieties.

Autor: Xue-Kun Liu¹ liuxuekunth@126.com, Long-Xu Ma² xuekunliu@sina.com, Zhi-Yu Wei² 15981392912@163.com, Xun Cui³ cuixun@ybu.edu.cn, Shi Zhan⁴ yqwang@126.com, Xiu-Mei Yin² xmyin@ybu.edu.cn, Hu-Ri Piao² piaohr@ybu.edu.cn

Publikováno v: Molecules. Feb2017, Vol. 22 Issue 2, p273-281. 9p. 2 Diagrams, 1 Chart, 2 Graphs.

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Synthesis and evaluation of the antimicrobial activities of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives

Autor: Ya-Ru Li, Meng-Xiao Wang, Shao-Pu Hou, Hu-Ri Piao, Long-Xu Ma, Jia-Chun Liu, Chang-Ji Zheng

Publikováno v: European Journal of Medicinal Chemistry. 74:405-410

Two novel series of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives were designed and synthesized, and their anti-bacterial activities evaluated. These compounds showed broad-spectrum inhibitory activities against both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9710758efba628b73dbd007293d9b3
https://doi.org/10.1016/j.ejmech.2013.12.054

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Synthesis and positive inotropic evaluation of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties

Autor: Li-ping Liu, Xun Cui, Jia-Chun Liu, Long-Xu Ma, Yan Wu, Hu-Ri Piao, Bai-ri Cui

Publikováno v: Bioorganicmedicinal chemistry letters. 24(7)

Four series of [1,2,4]triazolo[3,4- a ]phthalazine and tetrazolo[5,1- a ]phthalazine derivatives bearing substituted piperazine moieties were synthesized and evaluated for their positive inotropic activity by measuring the left atrium stroke volume i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb21fac9f80953c76be103b5182ad1ac
https://pubmed.ncbi.nlm.nih.gov/24636107

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ChemInform Abstract: Synthesis of New Triazole Acetamides with Inotropic Effects

Autor: Yan Wu, Long-Xu Ma, Xun Cui, Liang-Peng Sun, Hu-Ri Piao, Ming-Xia Song

Publikováno v: ChemInform. 44

A series of new triazole acetamides (III) is synthesized and screened for their positive inotropic activity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b91d808c67203508443146a614e31b3
https://doi.org/10.1002/chin.201321151

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ChemInform Abstract: Synthesis and Positive Inotropic Evaluation of (E)-2-(4-Cinnamylpiperazin-1-yl)-N-(1-substituted-4,5-dihydro [1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides

Autor: Fan-Ling Meng, Xun Cui, Tian-Wei Niu, Long-Xu Ma, Yan Wu, Hu-Ri Piao

Publikováno v: ChemInform. 44

Most of the compounds (I) show inotropic effects, with compound (Ie) possessing 6-7fold more potent activity than the reference drug milrinone.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12a13ec275e72b0fb115490dd2a71fe6
https://doi.org/10.1002/chin.201315175

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Synthesis of new triazole acetamides with inotropic effects

Autor: Xun Cui, Yan Wu, Ming-Xia Song, Liang-Peng Sun, Long-Xu Ma, Hu-Ri Piao

Publikováno v: Bioorganicmedicinal chemistry letters. 23(3)

A series of new triazole acetamides 5a–w were synthesized and evaluated for their positive inotropic activity of left atrium stroke volume on isolated rabbit-heart preparations. The majority of the derivatives presented favorable in vitro activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f363c477158e11df040703071ea49b62
https://pubmed.ncbi.nlm.nih.gov/23265872

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Synthesis and biological evaluation of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted benzylpiperazine moieties as positive inotropic agents

Autor: Ming-Xia Song, Jian Che, Liang-Peng Sun, Xun Cui, Hu-Ri Piao, Yan Wu, Long-Xu Ma

Publikováno v: Chemical biologydrug design. 81(5)

Two series of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted benzylpiperazine moieties have been synthesized and evaluated for their positive inotropic activity by measuring left atrium stroke volume

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdbd8f73b44f55e6c92268ae266f3fe
https://pubmed.ncbi.nlm.nih.gov/23279930

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Synthesis and positive inotropic evaluation of (E)-2-(4-cinnamylpiperazin-1-yl)-N-(1-substituted-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides

Autor: Fan-Ling Meng, Tian-Wei Niu, Xun Cui, Long-Xu Ma, Hu-Ri Piao, Yan Wu

Publikováno v: Archiv der Pharmazie. 345(12)

A series of (E)-2-(4-cinnamylpiperazin-1-yl)-N-(1-substituted-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides were synthesized and evaluated for their positive inotropic activity by measuring the left atrium stroke volume on isolated rabbi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3166287c9fffc75f9118a8c8c5510b9f
https://pubmed.ncbi.nlm.nih.gov/23015381

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Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties

Autor: Long-Xu Ma, Tian-Wei Niu, Yan Wu, Xun Cui, Hu-Ri Piao

Publikováno v: Bioorganicmedicinal chemistry letters. 22(13)

Two series of N -(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3- a ]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties were synthesized and screened for their positive inotropic activity by measuring left atrium stroke volume on is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bbdb07895c5a65c4250f2e461e5b0d
https://pubmed.ncbi.nlm.nih.gov/22672796

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