Zobrazeno 1 - 10
of 322
pro vyhledávání: '"Long-Jun Wu"'
Autor:
Lingxiao Wang, Jiaying Zheng, Shunyi Zhao, Yushan Wan, Meijie Wang, Dale B. Bosco, Chia-Yi Kuan, Jason R. Richardson, Long-Jun Wu
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114120- (2024)
Summary: Border-associated macrophages (BAMs) are tissue-resident macrophages that reside at the border of the central nervous system (CNS). Since BAMs originate from yolk sac progenitors that do not persist after birth, the means by which this popul
Externí odkaz:
https://doaj.org/article/1fe9f860912047bb96277f86c87ec85f
Autor:
Sheng Yang, Chuan Qin, Man Chen, Yun‐Hui Chu, Yue Tang, Luo‐Qi Zhou, Hang Zhang, Ming‐Hao Dong, Xiao‐Wei Pang, Lian Chen, Long‐Jun Wu, Dai‐Shi Tian, Wei Wang
Publikováno v:
Advanced Science, Vol 11, Iss 10, Pp n/a-n/a (2024)
Abstract Microglia, the major resident immune cells in the central nervous system, serve as the frontline soldiers against cerebral ischemic injuries, possibly along with metabolic alterations. However, signaling pathways involved in the regulation o
Externí odkaz:
https://doaj.org/article/f6b9009f4a954c11b65cd093810c441d
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-21 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of both upper and lower motor neurons, resulting in muscle weakness, atrophy, paralysis, and eventually death. Motor cortical hyperexci
Externí odkaz:
https://doaj.org/article/83cd1995f4b841708a89b219749e2949
Autor:
Nicholas L. Weilinger, Kai Yang, Hyun B. Choi, Christopher J. Groten, Stefan Wendt, Madhuvika Murugan, Leigh E. Wicki-Stordeur, Louis-Philippe Bernier, Prashanth S. Velayudhan, Jiaying Zheng, Jeffrey M. LeDue, Ravi L. Rungta, John R. Tyson, Terrance P. Snutch, Long-Jun Wu, Brian A. MacVicar
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113128- (2023)
Summary: Neuronal swelling during cytotoxic edema is triggered by Na+ and Cl− entry and is Ca2+ independent. However, the causes of neuronal death during swelling are unknown. Here, we investigate the role of large-conductance Pannexin-1 (Panx1) ch
Externí odkaz:
https://doaj.org/article/15c0151341174dd0a284baf30f872a0d
Autor:
Nan Gu, Min-Hee Yi, Madhuvika Murugan, Manling Xie, Sebastian Parusel, Jiyun Peng, Ukpong B. Eyo, Christine L. Hunt, Hailong Dong, Long-Jun Wu
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-19 (2022)
Abstract Microglia are highly dynamic immune cells of the central nervous system (CNS). Microglial processes interact with neuronal elements constantly on the order of minutes. The functional significance of this acute microglia-neuron interaction an
Externí odkaz:
https://doaj.org/article/ca2856cf259e4748b8e63effb6e058f4
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/24ccdbdd57c0466492abe30fe716f66d
Autor:
Chuan Qin, Sheng Yang, Man Chen, Ming-Hao Dong, Luo-Qi Zhou, Yun-Hui Chu, Zhu-Xia Shen, Dale B. Bosco, Long-Jun Wu, Dai-Shi Tian, Wei Wang
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106588- (2023)
Summary: Microglia exhibit diverse phenotypes in various central nervous system disorders and metabolic pathways exert crucial effects on microglial activation and effector functions. Here, we discovered two novel distinct microglial clusters, functi
Externí odkaz:
https://doaj.org/article/679353d10d6a4ca0a2220caa6d2d9783
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 6, Pp 1183-1189 (2022)
After spinal cord injury, microglia as the first responders to the lesion display both beneficial and detrimental characteristics. Activated microglia phagocyte and eliminate cell debris, release cytokines to recruit peripheral immune cells to the in
Externí odkaz:
https://doaj.org/article/a8a094702ac24906b834500d5d908440
Autor:
Dai-Shi Tian, Chuan Qin, Luo-Qi Zhou, Sheng Yang, Man Chen, Jun Xiao, Ke Shang, Dale B. Bosco, Long-Jun Wu, Wei Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Revascularization and angiogenesis, as substrates of sustained collateral circulation, play a crucial role in determining the severity and clinical outcome of acute ischemic stroke (AIS) due to large vessel occlusion (LVO). Developing an adj
Externí odkaz:
https://doaj.org/article/b401d6be021145b4bb07e4db3b0ba40e
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/be045446f4fc4911b7014ffd3885c4b6